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Original Article
Epidemiology and Vaccine Efficacy of Measles During the 1993 measles Epidemic
Soon Ki Kim, Jong Woon Choi, Byong Kwan Son, Seung Nam Park, Churl Young Chung, Young Min Ahn, Chong Young Park, Ki Yang Ryoo, Woo Kap Chung, Hoan Jong Lee
Clin Exp Pediatr. 1995;38(6):778-785.   Published online June 15, 1995
Purpose : Because of increased measles incidence in Korea during 1993 and the recent finding of genomic differences between vaccine virus and contemporary wild measles viruses, we conducted a measles vaccine efficacy study involving children ages 1 to 5 yeark, with the demographic analysis of patients brought to the hospitals during measles outbreak that had occurred 1993 in Seoul and...
Immunogenicity and Safety of Live Attenuated Vaccine(MAV/06srtain) on Healthy Children and Immunocompromised Children
Young Mo Sohn, Chul Joo Yu, Pyung Kil Kim, Kir Young Kim, Chong Young Park, Mi Ran Kim, Woo Kap Jeung, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
Clin Exp Pediatr. 1995;38(6):771-777.   Published online June 15, 1995
Purpose : To study the safety and immunogenicity of new live attenuated varicella vaccine (MAV/06strain) in normal healthy children and immunocompromized children in Korea. Methods : Blood samples for fluorescent antibody to membrane antigen(FAMA) assay were taken before the vaccination among seven hundred forth five healthy children and twenty two nine immunocompromised children. One hundred and seventy seven children and twenty...
Diagnostic Value of Stable Microbubble Rating test and Efficacy of Surfactant Replacement Therapy in Neonates with Respiratory Distres syndroems
Jeong Hee Kim, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(6):760-770.   Published online June 15, 1995
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and...
Intracraial Hemorrhage in Premature and Low Birth Weight Infants by Craniosonography
Seung Hee Choi, Jae Ock Park, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1995;38(6):752-759.   Published online June 15, 1995
Purpose : Intrabventricular hemorrhage is a common neuropathologic finding in premature and low birth weight infants. It is deeply related with neonatal death and neurologic sequelae. We want to know the incidence and the relating factors of intracranial hemorrhage in premature and low birth weight infants. Methods : We performed craniosonography in 170 premature and low birth weight infants in 3-7...
A Study on the Necessity to Revise the Present Growth Data for Height and Weight? -Base on Data from the Circumference and Triceps Thickness-
Gi Dong Hwang, Jae Kyung Choi, Jeh Hoon Shin, Nam Soo Kim, In Joon Seol, Hahng Lee
Clin Exp Pediatr. 1995;38(6):745-751.   Published online June 15, 1995
Purpose : Applying the present growth curve(established in 1985) in practice, we noticed some difference. And so, we performed this study to know that is it necessary to revise the present standard data in Korea. Methods : We checked the height and weight of 208 children of one primary school in Seoul. And also, we measured arm circumference and triceps thickness...
Prophylactic Effect of Diazepam to Prevent Recurrent Febrile Seiz
Seung Eun Choi, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Clin Exp Pediatr. 1995;38(5):685-691.   Published online May 15, 1995
Purpose : The purpose of this study was to investigate efficacy of shortterm diazepam prophylaxis in recurrent febrile seizure. Methods : A total of 107 children admitted to the department of pediatrics, Kangdong Sacred Heart Hospital, Ballym University from 1 July 1991 to 31 December 1992, with their first or recurrent febrile seizures(one or two times), were entered in the study,...
Stem Cell Transplantation in Umbilical Cord Blood(I) Expansion Effects of Stem Cells in Umbilical Cord Blood with Various Hematopoietic Growth Factors
Kyung Ha Ryu, Myung Hee Chung
Clin Exp Pediatr. 1995;38(5):675-684.   Published online May 15, 1995
Stem cell transplantation is used for the patients lacking the capability of production of hem-atopoitic cells. Recently, there have been a few studies using the umbilical cord blood as a sou-rce of stem cells, however it remains unclear whether umhhilical cord blood contains sufficient amount to reconstitute the patient. Our study was designed to know that umbilical cord blood is proper...
Midterm Result after Transcatheter Occlusion of Patent Ductus Arteriosus with Rashkind PDA Umbrella Device
Chung Il Noh, Eun Sook Han, Ho Sung Kim, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1995;38(5):668-674.   Published online May 15, 1995
Purpose : To evaluate the appropriateness of the transcatheter occlusion with Rashkind um-brella occlusion device Methods : Among the 54 cases who had been tried transcatheter closure of patent ductus ar teriosus from January, 1992 till December, 1993 at Seoul National Univerity Children's Hospital, the first follow-up evaluation with Doppler echocardioram were done in 43 cases at the mean i-nterval of...
Structure and Expression of Human Antibody Clones Specific for H. influenzae type b Capsular Polysaccharides
Kyung Hyo Kim, Gook Hyun Chung, Mitchell G. Scott, Moon H. Nahm
Clin Exp Pediatr. 1995;38(5):649-659.   Published online May 15, 1995
Purpose : Haemophilas influenzae type b is a significant pathogen in children and several v accines with different immunologic properties are clinically used. An individual produces oligoc-lonal anti-Hib-PS antibodies and the repertoire of human anti-HihPS Antibody (Ah) can be div- ided into two types by the structure of the light chain V region. Ah using A2-VK II gene product, which...
A Clinical Study of Tsutsugamushi Disease in Children
Jee Yeon Song, Ji Whan Han, Sung Soo Hwang, Kyung Yil Lee, Kyong Soo Lee
Clin Exp Pediatr. 1995;38(5):641-648.   Published online May 15, 1995
Purpose : Recently in Korea, there has been an increasing concern regarding Tsutsugamus-hi disease. This disease is increasingly reported in children. The purpose of this study was to c-onsider the possibility that Tsutsugamushi disease may be diagnosed as eruptive disease or F UO( fever of unknown origin) Methods : We reviewed 17 clinically or serologically confirmed cases of Tsutsugamushi dis-ease from...
Evaluation of Culture Proved Tuberculosis Patients
Eun Kyung Lee, Jae Yoon Kim, Young Jin Hong, Don Hee Ahn
Clin Exp Pediatr. 1995;38(5):633-640.   Published online May 15, 1995
Purpose : Childhood tuberculosis is often asymptomatic with low culture rate, but it may res-ult in serious complications via hematogenous spread. Therefore, this study was done to evalu-ate clinical features, laboratory findings in tuberculosis patients proved by culture. Methods : We reviewed retrospectively the medical records of 48 cases of proved tubercul-sosis at the department of Pediatrics, National Medical Center, during...
Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis
Moon Kyu Kim, Dong Soo Kim
Clin Exp Pediatr. 1995;38(5):625-632.   Published online May 15, 1995
Purpose : Aseptic meningitis is an infection of CNS caused by virus and there are remarka-ble changes in endogenous cytokine level. Interleukin-6 is a pleiotropic and multi-functional cyt-okine and plays a central role in host defense mechanisms. We studied the IL--6 level in serum and CSF with the patients of aseptic meningitis and investigated the relationship of IL-6 with C...
Trend of Maternal Measles Antibody in Korean Infants before 10 Months of Age
Phil-Soo Oh, Sung Hee Oh
Clin Exp Pediatr. 1995;38(5):619-624.   Published online May 15, 1995
Purpose : The measles epidemic occurrence has not well been controlled in Korea. Vaccin- ation schedule for measles in Korea has been modified in several occasions with insufficient da ta base. The most recent recommendation is to immunize at 9 months of age with measles va-ccine(at 6 months of age during epidemics) and reimmunize at 15 months of age with...
A Study of Bone Marrow Density in Korean Children of Normal Growth and Development
Byung Yoen Kim, Young Guk Kim, Young Jun Kim, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1995;38(5):612-618.   Published online May 15, 1995
Bone mineral densitometry is a useful procedure for the early detection of metabolic bone diseases and bone density changes caused by long term drug use. Dual energy X-ray absorpt- iometry(DEXA), a recently developed diagnostic radiologic method for evaluating bone mineral density is widely used because of its high sensitivity, easily obtaine results. and low dose radi- ation exposure. The study...
The Therapeutic Effects of Dexamethasone Therapy in Neonate with Bacterial Meningitis
Eun Gyung Lee, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(5):602-611.   Published online May 15, 1995
Purpose : In experimental models of meningitis and in children with meningitis, dexametha-sone has been shown to reduce meningeal inflammation and to improve the outcome of disea-se. We studied the effects of dexamethasone administration in neonates(<2 month-old) with b-acterial meningitis. Methods : We retrospectively reviewed the medical records of 30 neonates admitted to the nursery, the Yonsei University College of Medicine...
Comparison of Oxygenation and Lung Damage of High Frequency Flow Interruption to Conventional Ventilation in Surfactant Deficient Rabbits
Chang Keun Kim, Churl Young Chung, Hye Jae Cho
Clin Exp Pediatr. 1995;38(5):591-601.   Published online May 15, 1995
Purpose : This study was performed kto evaluate the High frequency flow interruption(HFF I) can prevent the lung injury and achieve a bettre oxygenation than conventional ventilation(C V) in surfactant deficient lungs when associated with lung volume recruitment and maintenance, and the need of background intermittent mandatory ventilation(IMV) to prevent the progressive atelectasis during HFFI. Methods : Surfactant deficiency was produced...
Plasma Lipid Alteration in Leukemia and Solid Tumor
Eun Sik Kang, Myoung Soon Song, Hea Jin Cheoh, Kyu Chul Choeh
Clin Exp Pediatr. 1995;38(4):529-536.   Published online April 15, 1995
Purpose : A sensitive, specific blood test to detect cancer would be of great value but the search for such a test has been fruitless so far. In actual practice, there is often a considerable interval between the point at which a tumor could have been detected and the point at which it produces symptoms as a result of tumor...
Incidence and Complications of Obesity in Pubescent School Children
Boo Hyun Han, Duk Hi Kim, Yoo Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1995;38(4):520-528.   Published online April 15, 1995
Purpose : In recent years, obesity in children has become one of the major nutritional problems, and the trend is that number of obese children is increasing. The purpose of this research is to examine the incidence of obesity in pubescent school children in Seoul and Cheju, and to analyze body fat component, complications and eating habits of those obese...
A Comparative Study o fIntavenous Methylprednisolone Dosage for Treatment of Children with Acute Idiopathic Thrombocytopenic Purpura
Eun Ju Shin, Yeong Jae Song, Woo Yeong Chung, Tae Gyu Hwang, Soon Yong Lee
Clin Exp Pediatr. 1995;38(4):513-519.   Published online April 15, 1995
Purpose : It is well known that use of intranenous methylprednisolone(IVMP)for the patients with idiopathic thrombocytopenic purpura(ITP) is not only as effective as use of intravenous gammaglobulin to mincrease platelets quickly, but also the former is less expensive than the latter. As the adequate dosage of IVMP has not been fully elucidated, we have tried to determine it. Methods : The...
Analysis of Contaminated Ground Water Inducing Methemoglobinemia and Epidemiologic Investigation of Contaminated Ground Water
Bu Heon Lee, Ji Young Suh, Nam Su Kim, Hang Lee, Young Yeul Kim, Bo Youl Choi, Hung Bae Park, Min Young Kim, In Hak Yeo
Clin Exp Pediatr. 1995;38(4):507-512.   Published online April 15, 1995
Purpose : Drining of Nitrate-contaminated water has been the most common cause of acquired methemoglobinemia. We had cyanotic infant diagnosed as methemoglobinemia caused by feeding with powdered formula mixed with nitrate-contaminated ground water. Methods : We had done epidemiologic investigation to identify the cause of an infant's methemoglobinemia. Analysis of ground water and blood test of involved family members and neighbors...
Afebrile Convulsion Associated with Rotaviral Gastroenteritis in Childhood
Yoon Kyeong Koh, Yong Hoon Park, Han Ku Moon
Clin Exp Pediatr. 1995;38(4):501-506.   Published online April 15, 1995
Rotavirus is an important pathogen of acute infantile gastroenteritis as well as is suspected of being one of the causative agents of benign convulsion. We evaluated the clinical and laboratory features noted in 9 young children with Rotazyme positive gastroenteritis and afebrile seizure retrospectly. Seventy-seven patients were admitted to the department of pediatrics in Yeungnam University Hospital with a history of...
Clinical Study of Subarterial Ventricular Septal Defect
Yon Sook Rho, Yong Won Park, Sang Woo Kim, Bon Il Ku, Sang Joon Oh, Hong Sup Lee, Chang Ho Kim
Clin Exp Pediatr. 1995;38(4):493-500.   Published online April 15, 1995
Purpose : The incidence of subarterial ventricular septal defect(SA VSD) ranges 25-30% among oriental patients with VSDs, which is greater than 5% reported in western. Natural history of the disease is characterized by progressive aortic valve prolapse(AVP), frequently subarterial VSD, we evaluated clinical characteristics emphasizing on the incidence of AVP and the degree of AI as aging. Methods : Study subjects...
Serum Lipids in Children and Adolescents with Family History of Coronary Artery Diseases
Kee Hyoung Lee, Chang Sung Son, Joo Won Lee, young
Clin Exp Pediatr. 1995;38(4):482-492.   Published online April 15, 1995
Purpose : Atherosclerotic change begins in childhood, elevated blood lipid levels and a family history of premature coronary vascular diseases are important risk factors for coronary artery disease. Identification, follow-up and treatment of children at high risk of cardiovascular diseases are very effective and important for prevention of future coronary artery diseases. The purpose of this study is to determine...
Changes of Clinical Patterns of the Acute Rheumatic Fever in Korea(Compared report of 1973-1985 with that of 1986-1992)
Hye Sun Yoon, Min Young Park, Wan Young Shin, Byong Soo Sco, Sung Ho Cho
Clin Exp Pediatr. 1995;38(4):470-481.   Published online April 15, 1995
Purpose : The annual incidence of acute rheumatic fever in Korea was not changing during 1980 to 1989 from Nationwide survey in 1991 in spite of talking about scanty outbreak among doctors in recent year.The proportion of patients with acute rheumatic fever among the entire pediatirc inpatients each year was approximately 0.3% and did not change significantly throughout the...
Comparative Study of Oscillation of Pulmonary Artery Pressure to That of Systemic Artery Pressure
Hyang Ok Woo, Hyung Jin Kwon, Myung Kul Yum
Clin Exp Pediatr. 1995;38(4):461-469.   Published online April 15, 1995
Purpose : The purpose of this study is to examine the difference between the below respiratory-frequency oscillations of the pulmonary artery pressure and those of the systemic arterial pressure. Methods : The subjects in this experiment were patients suffering from ventricular septal defect and having treatment with the cardiac catheterization at Gyeongsang National University Hospital. Signals from pulmonary...
Neonatal Neurosonographic Findings, Cerebral Doppler and Electrophysiological Findings in Infants with Motor Idsturbance
Jae Kwang Kim, Kook In Park, Chang Il Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(4):445-460.   Published online April 15, 1995
Purpose : Neurosonography, cerebral doppler and electrophysiological study are valuable in predicting neurodevelopmental outcome. The purpose of this study was to analyze characteristics of neonatal neurosonographic findigs, cerebral doppler and electrophysiological findings in infants withmotor disturbance. Methods : The subjects were 33 infants hospitalized at Yonsei Severance Medical Center NICU from January, 1990 to December, 1992. 19 of these patients underwent...
A Clinical Study on Pauciarticular Juvenile Rheumatoid Arthritis(JRA)
Youn Soon Hahn, Jeoong Gon Kim
Clin Exp Pediatr. 1995;38(3):386-396.   Published online March 15, 1995
Purpose : The purpose of this study was to analyse clinical and laboratory patterns in patients in Korea with juvenile Rheumatoid Arthritis(JRA), pauciarticular type and to know the characteristics of pauciarticular JRA in Korea. Methods : Twenty-three cases of pauciarticular juvenile rheumatoid arthritis(JRA) who were diagnosed in the department of Pediatrics, Seoul National University hospital (from june 1988 to May 1994)...
A Study about Optimal Dose of Aspirin in Treating Kawasaki Disease
Yun-Jeong Chang, Seung-Kyoo Han, Soon-Ki Kim, Byong-Kwan Son, Jong-Woon Choi
Clin Exp Pediatr. 1995;38(3):378-385.   Published online March 15, 1995
Purpose : A prospective study was performed to evaluate the efficacies of two different dosages of aspirin(ASA) in treating Kawasaki disease(KD). Methods : Thirty-nine children with KD were admitted to this hospital from July, 1992 to May, 1993, and were assigned randomly into 2 groups. Group A(medium-dose group, 20 patients) was given 50mg/kg/d(# 4), and group B(high-dose gorup, 19 patients) was...
Infections in Children with Neoplastic Disease
Eun Hwa Choi, Jin Won Pyo, Jin Young Park, Kyung Bae Kwon, Bo Young Yun, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(3):366-377.   Published online March 15, 1995
Purpose : Infection is a major complication in patients with malignant disease. This study was performed to identify the causes and the etiologic agents of febrile infections and to characterize the clinical courses including the response to antimicrobial agents inpediatric cancer patients. Methods : This study reviewed 274 febrile episodes occurring in 163 children with neoplastic disease which were indentified prospectively...
Clinical Characteristics of Childhood Cerebrovascular Disease and Analysis on the Prognostic Factors
Yong Seung Hwang, Moon Sun Yang
Clin Exp Pediatr. 1995;38(3):353-365.   Published online March 15, 1995
Purpose : Cerebrovascular disease in children is more common than was once recognized and the etiology and prognosis of the disease in children are quite different from those of adults. Recently according to medical reports and clinical experiences, the incidence of childhood cerebrovascular disease is increasing in Korea. To clarify the clinical features of childhood cerebrovascular disease and to analyze its...
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