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Age Related Reference Ranges for Lymphocyte Subsets in Healthy Korean Children
Dong Un Kim, Joon Sung Lee
Clin Exp Pediatr. 1996;39(2):264-272.   Published online February 15, 1996
Purpose : This study was aimed to investigate the age related changes of lymphocyte subset values in healthy Korean children. Methods : Eighty healthy children were divided into four groups: group A(less than 1yr, n=20), group B(from 1 to 211/12 yr, n=20), group C(from 3 to 511/12 yr, n=20), group D(more than 6 yr, n=20). Their blood were examined for the...
The Effect of IFN-γ and PGE2 in the Production of TNF-α by Human PBMC Stimulated with LPS
Youn Soo Hahn, Joong Gon Kim
Clin Exp Pediatr. 1996;39(2):255-264.   Published online February 15, 1996
Purpose : The purpose of this study was to observe the effect of IFN-γ and PGE2 on TNF-α production by human peripheral mononuclear cells(PBMC) that were stimulated with LPS. Methods : PBMC were separated by Ficoll-Hypaque gradient centrifugation from human peripheral venous blood and were incubated for 72 hours with or without LPS, IFN-γ, PGE2, and indomethacin according to various conditions. TNF-α activity of...
Clinical Characteristics of Cerebrovascular Disease in Infants and Children and Its Outcomes
Young Jae Song, Tae Gyu Hwang, Soo Chun Kim
Clin Exp Pediatr. 1996;39(2):246-254.   Published online February 15, 1996
Purpose : The incidence and clinical features of cerebrovascular disease in childhood were not clearly clarified in domestic. This study was undertaken to evaluate the clinical characteristics of cerebrovascular disease in infants and children, and its outcome, a retrospective study was performed to adequate management. Methods : We reviewed clinical records of the patients who had admitted to Inje University Pusan...
Bacteriological Survey of beta-Hemolytic Streptococci from the Throats of Elementary School Children in Chinju -Compared with the Results of Children in Kangwon, Chungnam and Seoul-
Seon-Ju Kim, Kook-Young Maeng, Hyang-Im Lee, Yun-Kyong Cho, Hee-Sang Yun
Clin Exp Pediatr. 1996;39(2):238-245.   Published online February 15, 1996
Purpose : Throat culture for streptococcal pharyngitis is a gold standard to diagnose, but it may be misleading to interpret due to the carriers. The isolation rates of beta-hemolytic streptococci (BHS) and Streptococcus pyogenes in the school children in Chinju were investigated and compared with those of Kangwon, Chungnam and Seoul previously reported. Methods : Throat cultures were taken from the...
The Study of Distribution of HI Antibody Titers Aganist Japanese Encephalitis Virus Among Children in Seoul
Jin A Kim, Tae Sung Ko, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Hae Wol Cho
Clin Exp Pediatr. 1996;39(2):230-237.   Published online February 15, 1996
Purpose : Incidence of Japanese encephalitis has been markedly decreased, but this disease is known to be high and lethal in the young age group. This study was designed to find out the HI antibody titers and associated factors of Japanese encephalitis of children in Seoul, and to establish the plan of vaccination. Methods : The survey was conducted from the...
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Immunologic Considerations in the Pathogenesis of Chronic and Recurrent Sinusitis in Children
Jun Ki Jung, Bok Yang Pyun, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1996;39(2):207-217.   Published online February 15, 1996
Purpose : Although the chronic sinusitis is one of the most common and troublesome respiratory diseases in children, the pathogenesis still remains unclear. It is suggested that many of the immunologic factors including allergic conditions may contribute the nasal inflammatory changes. This study was designed to evaluate and demonstrate the possible role of various immunologic factors on the pathogenesis of...
The Influence of the Use of Iodine during Perinatal Period on the Screening Test for Congenital Hypothyroidism
Gyu Bum Cho, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1996;39(2):195-206.   Published online February 15, 1996
Purpose : This study was performed to detect the diseases of congenital hypothyroidism by the neonatal mass screening test early and to demonstrate the possible role of topical iodinated antiseptics(povidone-iodine, PVP-Ⅰ) on transient hyperthyrotropinemia in newborn infants. Methods : We performed neonatal screening tests for inborn errors of metabolism since 1985 by Guthrie test for PKU, maple syrup urine disease, histidinemia,...
Serum Vitamin A Leveland Immunization Status in Serologically Confirmed Measles Patients
Kyung Hwa Park, Seung Hee Choe, Chang Hwi Kim, Dong Hwan Lee, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1996;39(2):187-194.   Published online February 15, 1996
Purpose : To know the relationship between serum vitamin A level and clinical symptoms in measles patients and to re-evaluate the measles vaccination schedule, we performed this study. Methods : From Jan. to Jun. 1994, we checked serum vitamin A levels and compared with clinical symptoms, laboratory findings, complications and vaccination status in 153 patients with positive measles IgM by ELISA. Results :...
Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
Clin Exp Pediatr. 1996;39(1):106-114.   Published online January 15, 1996
Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy. Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid mothers and their babies between 1988 and 1994. Results :...
Evaluation of Abnormal Coronary Artery Flow in Anomalous Coronary Artery Connections by Pulsed and Color Doppler Echocardiography
Young Mi Hong
Clin Exp Pediatr. 1996;39(1):78-87.   Published online January 15, 1996
Purpose : Anomalous connection of coronary artery can result in damage of myocardial perfusion, myocardial infarction, or congestive heart failure. Echocardiography has been used to demonstrate coronary artery anomalies such as coronary artery fistula, anomalous origin of the left coronary artery from the pulmonary artery, and aneurysm of the coronary arteries in Kawasaki disease. Definitive diagnosis relies on cardiac catheterization The...
Early Postoperative Results of the Large Ventricular Septal Defect in Infants Younger Than 1 Year of Age
Man-Teak Oh, Hyang-Suk Yoon, Jong-Bum Choi
Clin Exp Pediatr. 1996;39(1):72-77.   Published online January 15, 1996
Purpose : We report the results of a policy of primary surgical closure of large ventricular septal defects(VSDs) applied over the past 3 years to all symptomatic infants regardless of patient weight, location or number of VSDs. To analyze the early postoperative mortality and other surgical complications in young infants, comparison of preoperative and outcome variables were made between infants...
Epidemiologic Study of Measles Outbreak in School-Aged Children in East KyongGi-Do Area
In Kyu Yi, Jong Woon Choi, Soon Ki Kim, Byong Kwan Son, Jeung Gyu Kim, Seong Ki Yu, Myung Cheol Joe, Il Suk Jang
Clin Exp Pediatr. 1996;39(1):63-71.   Published online January 15, 1996
Purpose : There was marked decline of measles outbreak in the world since the first measles vaccine had been introduced. Recently, however, measles outbreak in the vaccinated children have been reported worldwide, which was ascribed to the possibilities of primary or secondary vaccine failure. We investigated the incidence in the school-aged children in the Kyong-gi Do area, the larger district...
Pulmonary Function Test in Korean Neonates by Expiratory Flow-Volume Curve
So Young Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(1):53-62.   Published online January 15, 1996
Purpose : Neonatal pulmonary function test(PFT) adds a new dimension to the understanding and care of the infant at risk for lung dysfunction. PFT can be identified the risk for pulmonary problems and safely and effectively diagnosed, quantified, and qualified the dysfunction. So it is possible to early institution of prophylatic respiratory therapy in such neonates and it can improved...
Report of Nationwide Epidemiology of Aseptic Meningitis Outbreak in 1993 in Korea
Sung Hee Oh, Moo-Song Lee, Jin Han Kang, Chang Hwi Kim, Chong Young Park, Young Mo Sohn, Hoan Jong Lee, Chung Sik Chun, Sang Mann Shin
Clin Exp Pediatr. 1996;39(1):42-52.   Published online January 15, 1996
Purpose : There has been no nationwide report pertaining to the epidemiology of aseptic meningitis, although a great numer of patients have been diagnosed of the illness. Therefore, we report an explosive outbreak of aseptic meningitis occured in a nationwide scale in 1993. Methods : Aseptic meningitis epidemiology surveillence was performed retrospectively on the patients diagnosed of aseptic meinigitis from January...
3 Cases of Kawasaki Disease Associated Thrombocytopenia
Hye Soon Kim, Young Mi Hong, Seung Joo Lee
Clin Exp Pediatr. 1995;38(12):1686-1690.   Published online December 15, 1995
Kawasaki disease may be associatde with a variety of hematologic abnormalities, the most characteristic being thrombocytosis. Thrombocytopenia, in contrast, appears to occur rarely in children with this disease. Hera et al observed the 2% manifested thrombocytopenia early in their illness. To our knowledge, early thrombocytopenia has not been reported in other populations, We report the case of a children with...
Cushing Syndrome in Children and Adolescents
Choong Ho Shin, Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1995;38(12):1677-1685.   Published online December 15, 1995
Purpose : Cushing syndrome occurs rarely in children and adolescents. The clinical manifestation is variable and growth is usually adversely affected. Methods : We retrospectively analyzed 8 patients with Cushing syndrome between the ages of 1 and 14 year who were admitted to the pediatric department of Seoul National University Children's Hospital during the period from 1978 to 1995. Results : 1)...
Responses to Growth Hormone Treatment in Children with Short Stature Secondary to Intrauterine Growth Retardation
Byung Churl Lee, Dong Won Kin, Byung Kyu Suh
Clin Exp Pediatr. 1995;38(12):1671-1676.   Published online December 15, 1995
Purpose : Several studies recently have emphasized the value of sonography as an new therapeutic method for hydrostatic reduction of intussusception by using a saline enema under ultrasound guidance. The purpose of this study was to asses the diagnostic screening efficacy of sonography in suspected childhood intussusception and the value of ultrasound guidance in hydrostatic reduction performed with saline enema. Methods...
Comparison of Diagnostic and Therapeutic Efficacy between Ultrasound Guided Hydrostatic Saline Reduction and Fluoroscopic Barium Reduction in Children with Intussusception
Chi Hyung Park, Ho Seok Lee, Chong Woo Bae, Sa Jun Chung, Young Mook Choi, Sun Wha Lee, Yup Yun
Clin Exp Pediatr. 1995;38(12):1664-1670.   Published online December 15, 1995
Purpose : Several studies recently have emphasized the value of sonography as an new therapeutic method for hydrostatic reduction of intussusception by using a saline enema under ultrasound guidance. The purpose of this study was to asses the diagnostic screening efficacy of sonography in suspected childhood intussusception and the value of ultrasound guidance in hydrostatic reduction performed with saline enema. Methods...
Evaluation of Severity of Childhood Pancreatitis with Multiple Factor Scoring Systems
Young In Choi, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(12):1653-1663.   Published online December 15, 1995
Purpose : Pancreatitis in children is not common but can be associated with severe morbidity rates. Early prognostic evaluation of acute pancreatitis assists in selecting those patients who should be closely monitored. We studied the clinical characteristics and prognostic factors in patients with acute pancreatitis. Methods : Twenty five children with pancreatitis were included ranging in age from 1.8 to 14.9...
CorreJation between High Blood Pressure and Lipid Profile in School Children
Young Mi Hong, Yun Ju Kang, Sung Jae Suh
Clin Exp Pediatr. 1995;38(12):1645-1652.   Published online December 15, 1995
Purpose : Adult essential hypertension begins in early childhood. Blood pressure patterns in children differ from those in adults, and the design of hypertension programs need to modified for young people. Hypertension in children is associated with several factors, but correlation with lipid profiles is not unknown. The purpose of this study is to analyze the affecting factors in child hypertension...
Placental Transfer of Anti-H. influenzae Type b Specific IgG and IgG Subclasses
Soo Hee Chang, Moon Hwan Lee, Pyoung Han Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1995;38(12):1638-1644.   Published online December 15, 1995
Purpose : Haemophilus injluenzae type b (Hib) is one of the most important causes of invasive bacterial diseases in infants and children. In Korea, however, the proportion occupied by Hib as a cause of pediatric pathogen seems to be less compared to those of western countries. This study was performed to provide the epidemiologic and immunologic basis of H influenzae type...
Infantile Choledochal Cyst Presenting with Neonatal Cholestasis; Review of Anatomical and Clinical Aspect
Jae Won Jeong, Jeong Kee Seo, Kwi Won Park, In Won Kim
Clin Exp Pediatr. 1995;38(12):1629-1637.   Published online December 15, 1995
Purpose : Extrahepatic biliary atresia, neonatal hepatitis, Allagille syndrome are most common primary causes of the neonatal cholestasis. Infantile choledochal cyst is another primary disease presenting with neonatal cholestasis but its incidence is so low that it has been reported rarely. Choledochal cyst in infancy has been known to have clinically and anatomically different characteristics from ones after infancy. Thus...
Changes of Cerebral Blood Flow Velocity before and after Closure of Ductus Arteriosus using Doppler Ultrasound in Normal Full-term Newborns
Myung Su Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(12):1620-1628.   Published online December 15, 1995
Purpose : With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns. Methods : Forty-two normal term...
Cytogenetic Analysis of Chorionic Villi of 240 Spontaneous Abortions
S. J. Kim, S. H. Lee, K. S. Cha, S. H. Park
Clin Exp Pediatr. 1995;38(12):1610-1619.   Published online December 15, 1995
Purpose : Chromosomal abnormality is one of the major causes of spontaneous abortion, especially in abortion of first trismester. To detect the incidence and kinds of chromosomal abnormalities, we analyzed karyotypes of 240 cases of spontaneous abortus. Methods : We analyzed karyotypes of 240 cultured chorionic villi of products of conceptus from pregnant women with spontaneous abortions visiting CHA general hospital...
Clinical Stududy of CATCH 22
Hye Soon Kim, Ho Sung Kim, Jung Il Rho, Jung Yeun Choi, Young Soo Yun, Jung Sun Kim, Jeong Wook Seo
Clin Exp Pediatr. 1995;38(12):1603-1609.   Published online December 15, 1995
The recognition that deletion of 22ql1 is a common cause of varied malformations and clinical disorders took more than a decade to achieve. Deletions of chromosome 22ql1 have been seen in association with DiGeorge syndrome (DGS) and velo¡ⓒ cardio-facial syndrome (VCFS). The large clinical overlap between DiGeorge syndrome and velo-cardio-facial syndrome suggest an aetiological connection. CATCH 22 synd¡ⓒrome is characterized...
Prevelance and Associated Factors of Childhood Obesity on the Elementary Students in Kwangju City
Myoung Sook Chung, Yung Il Rho, Eun Gyeoung Jung, Kyung Rye Moon, Sang Gee Park, Young Bong Park, So Yeon Ryu, Jong Park
Clin Exp Pediatr. 1995;38(11):1547-1557.   Published online November 15, 1995
Purpose : The prevalence of childhood obesity and its attendant morbidity have increased and the success of therapy for childhood obesity has been limited. It is important for us to recognize risk factors for the development of obesity in children. The purpose of our study is to provide useful information for the prevention and treatment of childhood obesity. Methods : A...
Ischemic Hepatitis in Children after Cardiac Operation -Analysis of Clinical Characteristics, Risk Factors and Outcome-
Kyung Mo Kim, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(11):1540-1546.   Published online November 15, 1995
Purpose : We have experienced frequently the ischemic hepatitis after cardiac operations which shows rapid striking rise of transaminase. But the ischemic hepatitis in children after cardiac operation is not defined yet in Korea. We examined the clinical characteristics and analyzed the risk factors and outcome in 20 children who showed typical clinical course of ischemic hepatitis after cardiac operation. Methods...
Prevalence and Its Changes of Hepatitis B Viral Markers from 1988 to 1993 in Korean Children
Jae Geon Sim, Jeong Kee Seo, Seong Jae Suh
Clin Exp Pediatr. 1995;38(11):1535-1539.   Published online November 15, 1995
Purpose : Hepatitis B infection is prevalent in Korea and active immunization of Hepatitis B has been proceeded intensively during the last decade. This study was designed to evaluate the changes of the prevalence of hepatitis B surface antigen (HBsAg) and that of antibody (HBsAb) in Korean children from 1988 to 1993. We can estimate the prevalence and tendency of...
Immunogenicity of a Recombinant Hepatitis B Virus Vaccine Compared With a Plasma-derived Hepatitis B Vaccin~ and of Vaccination Schedules in Neonates
Ae Sil Kang, Jong Sin Kim, Jae Won Huh, Chang Youn Lee, Hyun Gi Jung, Jae Sun Park, Kwang Soo Hwang
Clin Exp Pediatr. 1995;38(11):1525-1534.   Published online November 15, 1995
Purpose : Hepatitis B virus (HBV) vaccine was developed against HBV infection, and used widely in the world. The plasma-derived HBV vaccine was prepared from the plasma of chronic hepatitis B virus carrier. But, the plasma-derived HBV vaccine had many kinds of problems, such as the limitation of source, expensiveness, and the possibility of infection which spread through blood. To avoid these...
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