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Diagnostic Method of Congenital Cardiovascular Diseases Using Spiral Computed Tomography and Three Dimensional Reconstruction
Hye Kyung Lee
Clin Exp Pediatr. 1998;41(10):1389-1396.   Published online October 15, 1998
Purpose : One of the new methods for diagnosing congenital cardiovascular diseases is the spiral CT and three-dimensional image reconstruction. The spiral CT allows continuous data collection while the subject is advanced through the CT gantry, it provides an uninterrupted volume of data that can be reconstructed to produce a three-dimensional representation of CT information and also this method has...
Developmental Changes of Spectral and Chaotic Indexes of Heart Rate Variability in Normal Fetuses
Jee-Young Jung, Myung-Kul Yum, Nam-Su Ki, Jae-Won Oh, Chang-Ryul Kim, Jung Hye Hwang, Moon-Il Park
Clin Exp Pediatr. 1998;41(10):1380-1388.   Published online October 15, 1998
Purpose : The purposes of this study were to determine the normal values of spectral and chaotic indexes and to assess the maturational process of autonomic and chaotic control of fetal heart rate according to gestational age. Methods : Three hundred and thirty-seven mothers with normal singleton pregnancies, who were 23 weeks or more in gestational age, was randomly chosen. For...
Clinical and Pathological Comparison of Neonatal Hepatitis and Extrahepatic Biliary Atresia in Korean Children
Jae Hong Park, Ju Suk Lee, Su Eun Park, Chang Hun Lee
Clin Exp Pediatr. 1998;41(10):1372-1379.   Published online October 15, 1998
Purpose : Neonatal hepatitis and congenital extrahepatic biliary atresia are two major causes of neonatal cholestasis. But the method of therapeutic trials used for each disease is essentially different. Nonetheless, it is very difficult to differentiate these diseases clinically and histologically. This study is aimed to find out major differences between the two by clinical characteristics and scoring of various...
Clinical Application of a Scoring System in the Diagnosis of Group A Streptococcal Pharyngitis
Hyeon-Bu Kim, Byung-Soo Cho, Sung-Ho Cha, Jeong-Hun Ha, Sun-Hee Kim, Gui-Sook Cho
Clin Exp Pediatr. 1998;41(10):1365-1371.   Published online October 15, 1998
Purpose : A scoring system could be clinically useful in determining cases in which a throat culture may be omitted or in cases whether antibiotics may be initiated or not. We propose to make a clinical guideline of antibiotics administration in patients with pharyngitis. Methods : From Apr. 1996. to Mar. 1997, throat cultures were taken from 321 cases(72 cases from...
Clinical Features and Endoscopic Findings of Helicobacter pylori Infection in Children
Seon Hee Kim, Cheol Ho Chang, Churl Young Chung
Clin Exp Pediatr. 1998;41(10):1359-1364.   Published online October 15, 1998
Purpose : Helicobacter pylori(H. pylori) is recognized as the cause of primary or unexplained gastrointestinal diseases in children as well as in adults. However, it is unclear whether H. pylori causes specific clinical symptoms or diseases. Therefore, we studied the clinical manifestations associated with H. pylori infection in consecutive symptomatic children undergoing diagnostic endoscopy. Methods : This study included 42...
The Diagnostic Value of Polymerase Chain Reaction in Mycoplasma pneumoniae Pneumonia
Han Wook Kang, Byung Moon Ahn, Moo Young Song, Eun Ryoung Kim, Suk Ho Choi, Il Soo Kim
Clin Exp Pediatr. 1998;41(10):1351-1358.   Published online October 15, 1998
Purpose : This study was performed to evaluate the polymerase chain reaction(PCR) in the diagnosis of Mycoplasma pneumoniae pneumonia in comparison with the specific antibody test. Methods : Five hundred and ten patients with pneumonia, ranging from the ages of 8 months to 15 years who were admitted in Sung-Ae and Kwangmyung Sung-Ae general hospitals from Nov. 1996 to Oct....
Immunologic Changes of HL-60 Cells by Differentiation Inducing Agents I : Phenotypic Differentiation of FcγR and Mac-1
Hye Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
Clin Exp Pediatr. 1998;41(10):1342-1350.   Published online October 15, 1998
Purpose : Fc receptors and Mac-1 play an important role in the protective response of granulocytes and monocytes against microbial infection. FcγRⅠ, FcγRⅡ, FcγRⅢ as well as CD11b/ CD18 have never been measured in a quantitative way during hemopoiesis. Thus we quantified the expression of FcγRⅠ, FcγRⅡ, FcγRⅢ, and CD11b/CD18 during hematopoietic differentiation using HL-60 cells, which was induced to...
Comparison of Treatment Course and Outcome between Medically and Surgically Treated Patent Ductus
Jeong Geun Kim, Jeong Nyun Kim, Dong Chul Park, Shin Yeong Lee, Hyun Chul Lee, Myung Jae Chey, Churl Young Chung,
Clin Exp Pediatr. 1998;41(10):1334-1341.   Published online October 15, 1998
Purpose : Early intervention is needed to treat patent ductus arteriosus(PDA) as it is a major cause of increased mortality in preterm infants. However, it is uncertain which is better, medical versus surgical management. We reviewed medical records to compare the treatment course and outcome between medically and surgically treated preterm PDA infants. Methods : Thirth-two Mechanically ventilated pretem infants(gestational age<34...
Clinical Effect of Bronchoalveolar Lavage in Ventilated Preterm Infants
Hyeon-Soo Lee
Clin Exp Pediatr. 1998;41(10):1329-1333.   Published online October 15, 1998
Purpose : Bronchoalveolar lavage(BAL) in ventilated neonates is a modification of routine endotracheal suction and is a potentially useful technique in studying the evolution and resolution of pulmonary inflammation. Therefore, this study is designed to investigate the effects of BAL on blood gases, blood pressure and heart rate in ventilated newborn infants with respiratory disease. Methods : Fourteen premature infants were...
Thyroid Hormone Concentrations in Preterm Infants
Sung Keun Moon, Jeong Nyun Kim, Mi Jung Park, Myung Jae Choi, Chrul Young Chung
Clin Exp Pediatr. 1998;41(10):1324-1328.   Published online October 15, 1998
Purpose : To establish reference ranges for thyroid hormone concentrations in premature infants, we measured T4 and thyroid stimulating hormone(TSH) concentrations and analyzed the relation to gestational age and birth weight. Methods : Serum T4 and TSH concentrations were measured by radioimmunoassay for 391 premature infants born in Sanggye Paik Hospital for two years and eight months. Results : Gestational age of...
The Significance of Family History, Immunoglobulin E, Total Eosinophils and Eosinophil Cationic Protein as a Predictor of Allergic Diseases
Dong Su Park, Hyun Hee Kim, Joon Sung Lee
Clin Exp Pediatr. 1998;41(9):1273-1282.   Published online September 15, 1998
Purpose : Family history of allergy and cord blood immunoglobulin E concentration have been proven to be predictors of the development of allergic diseases in children. The purpose of this study is to evaluate whether maternal, cord and baby's blood total eosinophils or eosinophil cationic protein(ECP) in addition to the above two predictors could be a predictor of subsequent allergic...
Thymopentin Therapy in Atopic Dermatitis
Geun Woong Noh, Ki Young Lee
Clin Exp Pediatr. 1998;41(9):1268-1272.   Published online September 15, 1998
Purpose : Atopic dermatitis is a chronic relapsing inflammatory skin disease that results from allergic reaction. Steroid therapy has become a major therapeutic modality for treatment of atopic dermatitis. Several immunomodulatory therapies have been tried for atopic dermatitis. In this study thymopentin therapy was performed and its clinical effects and laboratory results were evaluated. Methods : Atopic dermatitis with typical clinical...
The Clinical Significance of Serum Sodium Concentration in Febrile Convulsion
So Young Park, Seung Joo Lee
Clin Exp Pediatr. 1998;41(9):1262-1267.   Published online September 15, 1998
Purpose : Recently hyponatremia was reported to be common in febrile convulsion and related to the probability of a repeated convulsion. It was documented that hyponatremia lowers the threshold for convulsion in experiment animals. We therefore studied the relationship between hyponatremia and febrile convulsion. Methods : Serum sodium concentration was measured in 82 children with febrile convulsions and 66 age-matched febrile...
Short Term Effect of Recombinant Human Growth Hormone Therapy in Children with Chronic Renal Failure
Si-Whan Ko, Dong-Kyu Ji
Clin Exp Pediatr. 1998;41(9):1256-1261.   Published online September 15, 1998
Purpose : Growth retardation is one of the major side effects of chronic renal failure. In this study, the short-term growth promoting effect, effect on the chemical parameters, and probable side effects of growth hormone treatment to child patients with chronic renal failure were examined. Methods : The research sample was 5 child patients diagnosed with chronic renal failure and receiving...
Thyroid Function Studies in Patients Who Underwent Open Heart Surgery
Hyung Joo Sohn, Yu In Park, Chang Sung Son, Joo Won Lee, Young Chang Tockg
Clin Exp Pediatr. 1998;41(9):1250-1255.   Published online September 15, 1998
Purpose : Alteration in the serum level of thyroid hormone can occur following open heart surgery due to major stress and hemodilution after extracorporeal circulation but these changes have been ignored. The purpose of this study is to evaluate the changes of thyroid hormone level after open heart surgery and if these changes influence the prognosis. Methods : We evaluated 26...
Prevalence and Clinical Features of Wolff-Parkinson-White(WPW)- Type Ventricular Preexcitation Syndrome in Children
Byung Ju Kim, Jae Sook Ma
Clin Exp Pediatr. 1998;41(9):1243-1249.   Published online September 15, 1998
Purpose : This study was conducted to establish the prevalence and clinical features of WPW- type ventricular preexcitation syndrome in children. Methods : Eighteen patients were discovered by the mass heart disease screening using ECG on 47,691 elementary school children in Kwangju from September 1992 to December 1994(group 1), and 14 patients were diagnosed at the Department of Pediatrics, Chonnam...
Gastroesophageal Reflux Disease in Children with Chronic Cough
Pan Joo Lim, Jae Ock Park, Dong Hwan Lee, Sang Mann Shin, Dong Won Kim
Clin Exp Pediatr. 1998;41(9):1234-1242.   Published online September 15, 1998
Purpose : We investigated the incidence of gastroesophageal reflux disease(GERD) by 24-hour esophageal pH monitoring in patients who had chronic cough for more than 3 weeks. Methods : From January 1995 to August 1996, 33 patients with chronic cough which had lasted for more than 3 weeks were enrolled in the 24-hour esophageal pH monitoring. The result was interpreted with the...
Interaction of the mec Regulator Genes in Methicillin Resistant Staphylococcus
Young Choi, In Seok Lim, Tae Sub Shim, Mi Kyung Lee, Ae Ja Park
Clin Exp Pediatr. 1998;41(9):1224-1233.   Published online September 15, 1998
Purpose : Low-affinity penicillin-binding protein PBP 2a encoded by mecA is closely related to methicillin resistance in staphylococci, and the expression of PBP 2a is controlled by regulator elements encoded by mecR1 and mecI. Deletion or mutation which occurred in mecI is considered to be associated with constitutive production of PBP 2a. We investigated the distribution of mec regulator genes...
Clinical Manifestations and Hematologic Complications of Epstein-Barr Virus Infection in Korean Children
Seong Hoi Jeon, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee, Young Chang Tocko
Clin Exp Pediatr. 1998;41(9):1216-1223.   Published online September 15, 1998
Purpose : Epstein-Barr virus(EBV) is associated with various diseases and complications caused by the host's immune reactions. This study focuses on various clinical findings and hematologic complications in childhood EBV infection. Methods : The study group was thirty-eight EBV infected children(Anti-EBV VCA IgM; positive) who were admitted to the Department of Pediatrics, Korea University from January 1996 to July 1997. Patients...
The Effect of Empirical Antibiotics in Febrile Neutropenia
Ju Suk Lee, Young Tak Lim
Clin Exp Pediatr. 1998;41(9):1209-1215.   Published online September 15, 1998
Purpose : This study was designed to evaluate the safety and efficacy of early cessation of antibiotic treatment regardless of absolute neutrophil count in children with febrile neutropenia and no identifiable infectious source. Methods : A prospective randomized clinical trial was performed in 93 episodes of fever in 37 neutropenic children with cancer, who were admitted to the Department of...
Delayed Cerebral Energy Failure After Acute Hypoxia-Ischemia in Neworn Piglet Under 48hours of Continuous Monitoring Using Near-Infrared Spectroscopy
Yun Sil Chang, Won Soon Park, Munhyang Lee, Ki-Soo Kim, Jung-Hwan Choi, Son Moon Shin
Clin Exp Pediatr. 1998;41(9):1198-1210.   Published online September 15, 1998
Purpose : To test the hemodynamic and biochemical sequences of secondary cerebral energy failure after acute reversed hypoxic ischemic brain insult(HI) can be reproduced in newborn piglets. Methods : Fifteen anesthetized, ventilated newborn piglet(<3 day) were studied. Eight(HI) were induced transient HI by breathing 8% oxygen and complete occlusion of bilateral common carotid arteries for 30 minutes followed by reoxygenation...
Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(9):1188-1197.   Published online September 15, 1998
Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one...
Effect of Dexamethasone on Preventing the Laryngeal Edema Following Extubation in Neonates
Joon Sung Kim, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(9):1180-1187.   Published online September 15, 1998
Purpose : We performed this study to evaluate the clinical efficacy and safety of dexamethasone in preventing laryngeal edema following exubation. Methods : We retrospectively reviewed the medical records of 100 neonates who underwent endotracheal intubation and mechanical ventilation. Subjects were divided into two groups; dexamethasone treated(60 cases, dexamethasone group) and non-treated(40 cases, control group). We examined the underlying diseases of...
A Study on the Factors Affecting Neonatal Birth Weight
Eun Young Hwang, Soo Beom Hwang, Jin Kil Par, Byung Mann Cho
Clin Exp Pediatr. 1998;41(9):1171-1179.   Published online September 15, 1998
Purpose : A low birth weight(LBW) rate is associated with perinatal morbidity and mortality. Many different factors are related to birth weight and LBW. This study examined the effects of various factors on birth weight. Methods : The study was conducted from January 1997 to August 1997 through direct interview with mother and medical history. Sample were drawn from 1,248 pairs...
Decrease of Plasma Th2 Cytokines by Interferon(IFN) -γ Therapy in Atopic Dermatitis
Geun Woong Noh, Woo Gill Lee, Dong Hee Cho, Ki Young Lee
Clin Exp Pediatr. 1998;41(8):1128-1134.   Published online August 15, 1998
Purpose : Atopic dermatitis is characterized by reduced IFN-γ production and increased IL-4 production. As a result, IgE production increases in atopic dermatitis. In the previous studies, it was reported that recombinant IFN-γ therapy is effective in treatment of severe atopic dermatitis. In this study, changes of plasma IFN-γ, IL-4, IL-5 and IL-10 concentration by IFN-γ therapy were studied in...
Changes in Endocrine Function with Treatment of Intracranial Germ Cell Tumo
JS Lim, JS Hwang, SY Kim, KS Sim, CH Shin, SW Yang, YS Hwang, HS Ahn
Clin Exp Pediatr. 1998;41(8):1120-1127.   Published online August 15, 1998
Clinical Characteristics, Including Endocrinological Changes, of Optic Glioma in Children
Jee Suk Yu, Se Young Kim, Choong Ho Shin, Ki Joong Kim, Sei Won Yang, Yong Seung Hwang
Clin Exp Pediatr. 1998;41(8):1111-1119.   Published online August 15, 1998
Growth Status and Levels of Growth Factors in Children with Insulin-dependent Diabetes Mellitus
So Chung Chung, Duk Hee Kim
Clin Exp Pediatr. 1998;41(8):1102-1110.   Published online August 15, 1998
Purpose : It is well known that the linear growth velocity in children with insulin-dependent diabetes mellitus(type 1 DM) is closely related to metabolic control and onset age of the disease. Many studies have demonstrated growth impairment in children with type 1 DM, regardless of the degree of metabolic control, whereas other studies have found no growth retardation. Therefore, we...
Correlation Between Clinical and Pathological Prognositic Factors of IgA Nephropathy in Children
Hwang Jae Yoo, Bon Su Ku, Young Tak Lim, Su Yung Kim
Clin Exp Pediatr. 1998;41(8):1093-1101.   Published online August 15, 1998
Purpose : Clinical and pathological prognostic factors of idiopathic IgA nephropathy have been reported, but mostly in adults and a few in children. Especially studies about correlation between those factors are very rare. Methods : We studied 58 children patients who were hospitalized to our clinics and diagnosed as IgA nephropathy by renal biopsy from Jan. 1989 to Jun 1996. They...
A PCR Assay of Gastric Biopsy Specimens for the Diagnosis of Helicobacter pylori Infection in Children
Jeong Wan Seo, Mi Ae Lee, Woon Sup Han
Clin Exp Pediatr. 1998;41(8):1084-1091.   Published online August 15, 1998
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