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Serum Levels of Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Protein-3 between Short Children with or without Intrauterine Growth Retardation
Kye Shik Shim, Se Young Kim, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 1999;42(3):390-396.   Published online March 15, 1999
Purpose : Postnatally, 20% of children with intrauterine growth retardation(IUGR) has no catch- up growth, This might be dependent on the serum level of Insulin-like growth factor I(IGF-I), resulting in shortness. We measured serum levels of IGF-I and Insulin-like growth factor binding protein-3(IGFBP-3) in children with IUGR and normal short stature variants(NSSV) to observe whether they play a role in...
Treatment Outcomes in Children with High-Risk Acute Lymphoblastic Leukemia
Kyu Chang Park, Ho Joon Im, Sang Yun Ahn, Hahng Lee
Clin Exp Pediatr. 1999;42(3):383-389.   Published online March 15, 1999
Purpose : The survival rate of those with acute lymphoblastic leukemia(ALL) has been affected by several prognostic factors and previous reports show that a 4-year event-free survival(EFS) for high-risk(HR) group(Age≥10 years and/or WBC≥50,000/mm3 at diagnosis) was approximately 64%. We analyzed treatment outcomes and risk factors in HR-ALL. Methods : Medical records of 27 patients with HR-ALL diagnosed between May, 1985 and...
Clinical Significance of CD7 Expression in Acute Myelocytic Leukemia
Gye Jin Yoon, Pill Sang Jang, Young Choi, Jun A Lee, Hyo Jung Han, Hyoung Soo Choi, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1999;42(3):374-382.   Published online March 15, 1999
Purpose : It has been shown that a considerable number of acute myeloid leukemia(AML) patients had both myeloid and lymphoid antigens. CD7 is a lymphoid antigen, often expressed in AML cells. We investigated 40 AML patients to clarify the relationship between the cellular characteristics and clinical features. Methods : We reviewed 8 CD7 positive(CD7＋) AML patients and 32 CD7 negative(CD7－)...
A Clinical Study of Migraine and Tension-type Headache in Children
Sang-Soo Park, Nam-Cheol Cho, Gyue-Gun Hwang
Clin Exp Pediatr. 1999;42(3):364-373.   Published online March 15, 1999
Purpose : The purpose of this study is to help diagnosis migraine and tension-type headache in children with chronic recurrent headache by comparing clinical characteristics of migraine and tension-type headache Methods : We performed a clinical analysis of 89 children diagnosed as migraine and/or tension- type headache by using international headache society classification with the aid of Prenky’s criteria of migraine...
Functional Differentiation of HL-60 Cells by Dimethylsulfoxide and Phorbol 12-myristate 13-acetate
Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh
Clin Exp Pediatr. 1999;42(3):355-363.   Published online March 15, 1999
Purpose : During hematopoietic differentiation of HL-60 cells by DMSO and PMA, we demonstrated functional changes of HL-60 cells-phagocytic activity, respiratory burst, antibody-dependent cell-mediated cytotoxicity(ADCC) and opsonophagocytic activity. Methods : HL-60 cells(ATCC CCL-240), cultured in RPMI 1640 and supplemented with 10% FBS, were induced to differentiate by adding 1.0% DMSO or 16nM PMA. On the 4th and 7th day after...
Clinical Utility of the Sputum Polymerase Chain Reaction Obtained by Nebulizer in the Diagnosis of Mycoplasma pneumoniae Pneumonia
Kye Nam Yoon, Sang Wook Park, Eui Ho Lee, Won Bae Lee, Kyung Tai Whang, Hee Jin Lee
Clin Exp Pediatr. 1999;42(3):348-354.   Published online March 15, 1999
Purpose : The polymerase chain reaction(PCR) has been used for the early diagnosis of mycoplasmal infections using various clinical samples. In this study, the clinical utility of sputum PCR through a new method was studied to diagnose mycoplasma pneumonia. Methods : One hundred nineteen pneumonic patients, ages ranging from 15 months old to 15 years old, were examined from Aug, 1997...
Anthropometric Measurement of Newborn in Women with Gestational Diabetes Mellitus
Kyung Hoon Kang, Seong Won Yang, Hye Kyung Han, Woo Gill Lee, Mi Na Lee, Hak Chul Jang, Il Soon Hwang, Eun Sung Kim
Clin Exp Pediatr. 1999;42(3):339-347.   Published online March 15, 1999
Purpose : To find the anthropometric characteristics of newborn in women with gestational diabetes mellitus(GDM), and the relationship between the birth weight and anthropometric measurements of newborn, maternal body habitus and glycemic control in GDM group. Methods : Maternal weight, height, and obstetric history of 82 women with GDM and 93 women with normal glucose tolerance were recorded at the...
Study of Nosocomial Infection of Rotavirus in Preterm and Full-term Neonates
Kwang Ok Chung, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Sun Hee Yu
Clin Exp Pediatr. 1999;42(3):332-338.   Published online March 15, 1999
Purpose : The present study was designed to investigate rotavirus infection by comparing clinical characteristics of the nosocomial infection of rotavirus between preterm and full-term neonates. Methods : The subjects were admitted from May to December, 1996. In 71 preterms, 44 were Rotazyme positive, 27 were negative, and in 321 full-terms, 64 were Rotazyme positive, 257 were negative. We studied the...
Gastric Emptying Time in Preterm Infents : Comparison between Breast Milk and Formula Milk
Seong Woo Roh, Seong Sook Jeon, Son Sang Seo, Jeong Mi Kwon
Clin Exp Pediatr. 1999;42(3):324-331.   Published online March 15, 1999
Purpose : Failure of adequate gastric emptying frequently interferes with successful enteral nutrition in infants. Study of gastric emptying in preterm infants has been hampered by the absence of a suitable and, valid technique, but ultrasonic assessment is well tolerated by infants. The aim of this study is to compare gastric emptying rates of breast milk and formula within preterm...
Diagnostic Utility of D-dimer Test in Disseminated Intravascular Coagulation with Sepsis
Jung Eun Kim, Young Mi Hong, Gyung Hee Kim
Clin Exp Pediatr. 1999;42(2):257-263.   Published online February 15, 1999
Purpose : Disseminated intravascular coagulation(DIC) is a confusing disorder from both a diagnostic and therapeutic standpoint. In order to investigate the effectiveness of D-dimer test in disseminated intravascular coagulation associated with sepsis, D-dimer level and other laboratory tests were performed. Methods : Fifty patients with disseminated intravascular coagulation associated with sepsis, who were admitted to the department of pediatrics, were evaluated by...
Clinical Study of Status Epilepticus in Children
So Young Lee, Seung Hee Jung, Yong Kuk Kim, Byung Hak Lim
Clin Exp Pediatr. 1999;42(2):249-256.   Published online February 15, 1999
Purpose : Convulsive status epilepticus(SE) is a serious, life-threatening neurological condition that requires immediate treatment to avoid significant morbidity and mortality. Despite improvements in the diagnosis and treatment of SE in the last two decades, SE in young infancy is still associated with high morbidity and mortality. Thus, understanding the varied etiology and clinical presentation and prognosis of SE is...
Distribution and Expression of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid(AMPA) Receptor Subunits in Moderate Hypoxic Newborn Piglet Brain
Na Yeon Kim, Woo Taek Ki
Clin Exp Pediatr. 1999;42(2):239-248.   Published online February 15, 1999
Purpose : The mechanism of hypoxic damage is mainly intracellular influx of calcium ions through the glutamate ionotropic receptor(NMDA, AMPA/kainate). This study was performed to determine alterations in distribution and expression of AMPA receptor subunits after 1-hour of moderate hypoxia in the newborn piglet brain, in a state of mild to moderate perinatal hypoxic-ischemic encephalopathy. Methods : Ten newborn piglets were...
A Clinical Study on Infantile Spasms with Vigabatrin Therapy
Seung Jung Oh, Sung Gun Park, Hyun Ho Kang, Sa Jun Chung
Clin Exp Pediatr. 1999;42(2):233-238.   Published online February 15, 1999
Purpose : Infantile spasms are considered an age-specific and malignant epilepsy. It is not controlled easily by general anticonvulsants. Therefore, this study aimed to assess vigabatrin(VGT) efficacy in infantile spasms. Methods : From January 1992 to December 1995, 35 children with infantile spasms, who were diagnosed at Kyung Hee University Hospital and treated vigabatrin, were analyzed retrospectively. Results : The ratio of...
Clinical Study of Post-Traumatic Seizure in Childhood and Adolescence
Jang Weon Moon, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 1999;42(2):227-232.   Published online February 15, 1999
Purpose : As morbidity and mortality resulting from physical trauma have significantly increased, the importance of trauma concerning medical, legal, and socioeconomic issues has been widely documented. Studies of post-traumatic seizure after head trauma have been reported, but mostly in adults. So this study was performed to analyse clinical findings on head trauma patients under 20 years of age. Methods :...
Predictive Factors of Saline Reduction under Ultrasound-guidance in Patients with Intussusception
Jung-Hye Min, Hye-Young Lee, Eun-Sun Yo, Jeong-Wan Seo, Seung-Joo Lee, Sun-Hwa Lee
Clin Exp Pediatr. 1999;42(2):221-226.   Published online February 15, 1999
Purpose : The purpose of this study was to investigate the predictive factors of saline reduction under ultrasound-guidance in patients with intussusception. Methods : Ultrasound-guided saline enema reductions were performed in 105 patients with intussusception from September 1993 to April 1996 at Ewha Womans University Mok-dong Hospital. Clinical characteristics and ultrasonographic findings were analyzed as the predictive factors of ultrasound-guided saline...
Assessment of Myocardial Ischemia using Myocardial Perfusion Scan in Kawasaki Disease
Hong Ryang Gil, Jung Yun Choi, Myeong Ja Yoon, Soon Seong Park, Ho Sung Kim, Chung Il No, Yong Soo Yoon, Myung Chul Lee, Dong Soo Lee
Clin Exp Pediatr. 1999;42(2):211-220.   Published online February 15, 1999
Purpose : Myocardial scintigraphy has been reported to be useful in adults, but its usefulness in children is limited. This study was done to determine the feasibility and accuracy of 99mTc-MIBI SPECT(sestamibi, methoxy-isobutyl-isonitrarite myocardial single emission computed tomography, Dp-SPECT) after dipyridamole infusion to detect coronary obstructive lesions in Kawasaki disease (KD). Methods : Dp-SPECT was performed in 21 control(group 1), 8...
Estimating Fetal Cardiac Output by Doppler Echocardiography
Young Mi Hong
Clin Exp Pediatr. 1999;42(2):203-210.   Published online February 15, 1999
Purpose : Doppler echocardiography has been used to identify fetal cardiac anatomy and hemodynamics. It can estimate flow velocity, volume, and cardiac output. The purposes of this study were to estimate right and left ventricular stroke volume and cardiac output in fetus, and to see if there were any changes of right and left ventricular parameter with fetal growth. Methods :...
Clinical Efficiency of Cardiac Troponin T for Myocardial Damage in Neonatal Asphyxia
Nam Soo Kang, Jae Kyun Yoon, Chang Sung Son, Joo Won Lee, Young Chang Tokgo, Sang Hee Kim
Clin Exp Pediatr. 1999;42(2):195-202.   Published online February 15, 1999
Purpose : The aim of this study was to evaluate the clinical efficiency of cardiac troponin T (cTnT) in detecting myocardial damage in neonatal asphyxia and to compare the diagnostic value of cTnT with creatine kinase MB(CK-MB). Methods : Sixty-three neonates were enrolled in this study, consisting of 27 asphyxiated infants (asphyxiated group; 1-min or 5-min Apgar score≤6) and 36 healthy...
Clinical Characteristics of Long-Standing Foreign Body in Airway
Jin Hwa Jeong, Seon Mi Jin, Yun Ae Jeon, Ki Woong Sung, Young Yull Koh
Clin Exp Pediatr. 1999;42(2):186-194.   Published online February 15, 1999
Purpose : Although the diagnosis of foreign bodies in the airway can be made early, retained and neglected foreign bodies are a common occurrence. The objective of this study was to characterize the clinical features of children diagnosed beyond 14 days following inhalation of a foreign body, long-standing foreign body in airway(LFB). Methods : We reviewed the records of 180 cases...
A Seroepidemiologic Study on Hepatitis A in Seoul, Korea
Dong Woon Yang, Young Ah Lee, Jung Yeon Shim, Jin Young Park, Hye Lim Jung, Moon Soo Park, Dong Hyeuk Keum
Clin Exp Pediatr. 1999;42(2):180-185.   Published online February 15, 1999
Purpose : The prevalence of hepatitis A(HAV) in a certain community reflects that community’s living standard and hygienic condition. And the pattern of HAV infection differs over time and geography, with varying widely from country to country and even within the same city. Recently a shift in prevalence has been observed in cases from childhood to adulthood. We studied HAV...
Significance of Polymerase Chain Reaction Test for Diagnosis of Mycoplasma pneumoniae Pneumonia
Hae-kyung Lim, Young-Hun Chung
Clin Exp Pediatr. 1999;42(2):173-179.   Published online February 15, 1999
Purpose : Mycoplasma pneumoniae is a common cause of lower respiratory disease, especially in children and young adults. The diagnosis, in most cases, is confirmed by serology. M. pneumoniae is difficult to culture because of its fastidious nature, and growth is too slow for diagnostic use. In this prospective study, the sensitivity and specificity of the PCR assay was evaluated...
Clinical Effect and Complication of High Frequency Ventilation on Respiratory Failure
Man Hoe Hur, Yong Gook Kim, Ji Yun Baek, Sang Geel Lee
Clin Exp Pediatr. 1999;42(2):164-172.   Published online February 15, 1999
Purpose : Flow interruptor high frequency ventilator(HFV) on neonatal respiratory failure caused by various disorders has been applied in order to assess its therapeutic effect and safety. Methods : Premature babies below 1.8kg with respiratory failure from 1991 to 1997 in the Fatima neonatal intensive care unit(NICU) for 6 year and 4 months are included. Flow interruptor HFV with low...
Changing Social Background Pattern of Children in Adoption Institutions(the 4th Report)
Hye Jeong Kim, Jin A Son, Jae Youn Kim, Don Hee Ahn
Clin Exp Pediatr. 1999;42(1):115-121.   Published online January 15, 1999
Purpose : A study was undertaken to assess the social background of abandoning children at adoption institutions. The results were compared to those of three previous reports from the institution. Methods : A total of 536 children who had been admitted to the institution during the period of 1993 to 1996 were subjected to the study. The medical records were...
The Relationship between IL-1β, TNFα, IL-6 and Factors Associated with Febrile Reactions to Transfused Blood
Hae Shin Kyung, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Kyung Hi Kim, Keun Lee
Clin Exp Pediatr. 1999;42(1):108-114.   Published online January 15, 1999
Purpose : Aggressive chemotherapy and bone marrow transplantation have a large demand for platelet concentrate and packed RBC transfusion. Febrile nonhemolytic transfusion reactions are an immunologically mediated reaction involving plasma in the recipient and the white blood cells in the donor. This study was performed to understand the role of cytokines and factors associated with febrile nonhemolytic transfusion reaction to...
The Effect of Long-term Steroid Therapy on Cardiac Function in Nephrotic Syndrome
Jae-Goo Lee, Hong-Ryang Gil, Jae-Ho Lee, Yong-Hun Chung
Clin Exp Pediatr. 1999;42(1):102-107.   Published online January 15, 1999
Purpose : The aim of this study is to assess the cardiac effect of long-term steroid therapy in nephrotic syndrome and the validity of LV functional parameters as an early predictor of subclinical cardiac dysfunction. Methods : The study group was composed of 21 patients diagnosed as minimal change nephrotic syndrome(NS), being managed with prednisone over 6 months or within 6...
Clinical Study in Nocturnal Enuretic Children
Dae Chull Jung, Won Jung Kim, Byeung Hee Son, Seung Won Kim
Clin Exp Pediatr. 1999;42(1):94-101.   Published online January 15, 1999
Purpose : Nocturnal Enuresis, an involuntary discharge of urine after bladder control, is frequent in children. It brings patients and family many psychogenic problems. So we investigated its clinical characteristics and drug effects. Methods : The study subjects enrolled were 36 children with nocturnal enuresis. We evaluated family history, accompanying urinary symptoms and clinical characteristics through questionnaries. We evaluated the effect...
The Utility of Serum Prealbumin Concentrations for Short-term Nutritional Assessment in Patients with Acute Diarrhea
Kyoung Ah Lim, Hae Soon Kim, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1999;42(1):88-93.   Published online January 15, 1999
Purpose : To evaluate the usefulness of serum prealbumin concentration for the nutritional assessment of acute diarrhea. Methods : From February 1997 to August 1997, ninety patients with acute diarrhea(age, 4-24 months) were randomly assigned into two groups on the basis of their intakes for 2 days prior to admission : liquid diet group(N=56, clear liquid and/or oral electrolyte solutions), and...
Clinical Study of Multiple Intestinal Ulcerations and Perforations Caused by Methicillin-Resistant Staphylococcus aureus in Infants
Seok Joo Han, Poong Man Jung, Jai-Eok Kim, Jeong Hong, Hoguen Kim, Inwha Seong, Eui Ho Hwang
Clin Exp Pediatr. 1999;42(1):77-87.   Published online January 15, 1999
Purpose : In recent years, the authors experienced a distinctive clinical entity of multiple intestinal ulcerations and perforations in infants. The purpose of this study was to describe the clinical characteristics of this entity, examine th possible pathogenesis and the effective treatment. Methods : Seven infants underwent abdominal exploration under suspicion of surgical abdomen and were noted to have multiple intestinal...
Clinical and Endoscopic Findings in Children with Duodenal Ulcer due to Helicobacter pylori Infection
Hwa Jung Kim, Hae Jeong Han, Sang Gil An, Ji Sook Yoo, Hee Sup Kim, Hann Tchah, Ho Jin Park, Mi Kyoung Shin
Clin Exp Pediatr. 1999;42(1):69-76.   Published online January 15, 1999
Purpose : Recently, a wide application of gastrofiberoscopy in pediatrics has revealed that the incidence of peptic ulcer has increased in the past years, and various results were reported about the relationship between duodenal ulcer and H. pylori. The aim of this retrospective study is to investigate the role of H. pylori in duodenal ulcers in children and to help diagnose and treat duodenal...
Clinical Manifestations of Dysphagia in Children
So Hee Chung, Nam Seon Beck, Munhyang Lee, Sang Il Lee, Heung Jae Lee, Jung Yun Choe, Hyun Suk Kim
Clin Exp Pediatr. 1999;42(1):60-68.   Published online January 15, 1999
Purpose : In children, dysphagia is a common cause of recurrent pneumonia and malnutrition and can be fatal. However, till now no studies were performed concerning the clinical investigation of dysphagia in Korea. Methods : In this study we evaluated the clinical manifestations of dysphagia in children with an age range between 1 month and 12 years by reviewing the...
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