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Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
Depolarization, Repolarization Inhomogeneity and Late Potential after Surgical Repair of Tetralogy of Fallot
Soo Young Kim, Myung Chul Hyun, Sang Bum Lee, Seung Tae Kim, Jong Soo Lee
Clin Exp Pediatr. 1999;42(8):1071-1077.   Published online August 15, 1999
Purpose : After repair of tetralogy of Fallot(TOF), ventricular arrhythmia and sudden death remain as serious late complications which are due to right ventricular systolic and diastolic overloading, exposure to hypoxia and surgical scar. Among the various methods for predicting the risk of such complications, we evaluated signal average ECG(SAECG), QRS duration, QT and JT dispersion, cardiothoracic(CT) ratio, age at...
Changes of Left Ventricular Diastolic Function in Normal Children
Jin-Hee Kim, Young-Yoo Kim, Won-Bae Lee, Jong-Wan Kim,, Kyung-Tai Whang
Clin Exp Pediatr. 1999;42(8):1063-1070.   Published online August 15, 1999
Purpose : Doppler echocardiography provides a noninvasive technique for the evaluation of left ventricular diastolic function. This study was performed to define the normal pattern of left ventricular diastolic filling by real-time Doppler flow mapping, and to determine how this pattern changes with aging in normal children. Methods : The changes in diastolic function in 89 normal subjects less than 15...
The Relation of Food-Specific IgE to Recurrent Wheezing Attack
Yun Jeong Yang, Jeong Hee Kim, Yoo Mee Choi, Dae Hyun Lim, Sei Woo Chung, Jeong Gyu Kim, Byong Kwan Son
Clin Exp Pediatr. 1999;42(8):1056-1062.   Published online August 15, 1999
Purpose : There were some reports that IgE-mediated food hypersensitivity is associated with subsequent development of atopic disease in wheezy infants. So we carried out this study to show whether the food specific IgE antibodies are useful to predict recurrent wheezing attack in wheezy infants. Methods : A total of 190 children younger than 4-year-old were enrolled in this study. They...
A Survey on Mothers' Perception of Breastfeeding
Ji Hye Jung, Keun Lee
Clin Exp Pediatr. 1999;42(8):1050-1055.   Published online August 15, 1999
Purpose : The objective of this investigation was to identify the postpartum change in breastfeeding rate and mothers' perception of breastfeeding. The investigation was carried out to make plans for the education of mothers regarding breastfeeding. Methods : Total of 284 mothers, who delivered healthy full-term babies at Dongdaemun Hospital, Medical College, Ewha Womans University, were interviewed and asked to complete...
Screening Device for Developmental Delay at Well Baby Visit
Keun Lee
Clin Exp Pediatr. 1999;42(8):1043-1049.   Published online August 15, 1999
Purpose : Developmental delay is a fairly common problem in childhood and its early diagnosis is crucial not only for the child but also for the family and society. If found early and properly managed, the side effects can be minimized and the child with developmental delay will have a better prognosis. However, early diagnosis is difficult due to various...
Effects of Growth Hormone Treatment on Alterations of Growth and Bone Metabolism in Rats Induced by Dexamethasone Administration
Woo Yeong Chung, Jeong Nyu Lee, Hye Kyoung Yoon
Clin Exp Pediatr. 1999;42(7):991-1002.   Published online July 15, 1999
Purpose : The aim of this study was to investigate the alterations of growth and bone metabolism in SDR induced by dexa administration and to evaluate the effects of GH treatment in dexamethasone(dexa) induced growth and bone metabolism in SDR. Methods : Forty-five female Sprague-Dawley rats(weight 150-170gm) were divided in 3 groups: Group 1(n=15) received normal saline as control, Group 2(n=15)...
Role of Polymorphism in HLA DQ-α and -β Chain Loci in the Pathophysiology of Autoimmune Thyroid Disease in Children with and without Turner Syndrome
Kye Shik Shim, Kyu Chul Choeh, Sei Won Yang, Sa Jun Chung, Jin Sung Lee, Kyung Tae Lee, Sung Ho Goh, Yong Sung Kim
Clin Exp Pediatr. 1999;42(7):980-990.   Published online July 15, 1999
Purpose : About 10% of girls with Turner syndrome may have autoimmune thyroid disease(AIT), but the disease's pathophysiology has not yet been elucidated. Accordingly, this study was performed to observe whether the pathogenesis of AIT in children with Turner syndrome and without Turner syndrome correlate with special loci of DQ α and β chain in HLA. Methods : Blood samples were...
Changes in GFAP Immunoreactivity of Astrocytes in Rats with Reye's Syndrome Induced by Valproic Acid and the Effects of Carnitine Supplementation
Young-Yoo Kim, Kyung-Tai Whang
Clin Exp Pediatr. 1999;42(7):966-979.   Published online July 15, 1999
Purpose : This study was designed to investigate whether valproic acid(VPA) induces Reye's syndrome by analyzing blood chemistry, carnitine(CARN) concentration, and the morphologic changes of hepatocytes. The changes of GFAP immunoreactivity of astrocytes were examined in rats with Reye's syndrome induced by VPA. And the effects of CARN supplementation on Reye's syndrome were also investigated. Methods : Ten rats were assigned...
Factors Associated with Renal Failure in Children with Primary Vesicoureteral Reflux
Kyung Mi Park, Kyung Hoon Paek, Jae Hong Min, Jung Su Kim, Il Soo Ha, Kwang Myung Kim, Hae Il Cheong, Hwang Choi, Yong Choi
Clin Exp Pediatr. 1999;42(7):959-965.   Published online July 15, 1999
Purpose : The pathophysiologic mechanisms and risk factors of renal functional deterioration are still controversial. We analyzed the factors associated with renal failure in children with primary vesicoureteral reflux. Methods : The medical records of 166 children who were diagnosed with primary vesicoureteral reflux from Jan. 1985 to Dec. 1996 in the Department of Pediatrics, Seoul National University Children's Hospital...
Effects of Cisapride on Action Potential Duration and on ATP-Sensitive K Channel in Guinea Pig Ventricular Muscles
Chan Uhng Joo, Young Jae Kim, Sung Ki Mun, Soo Wan Chae
Clin Exp Pediatr. 1999;42(7):953-958.   Published online July 15, 1999
Purpose : Cisapride(PrepulsidⓇ) has been recently associated with long QT syndrome. It has been reported to cause Torsades de Pointes and induce early afterdepolarization in rabbit Purkinje fibers. We investigated the electrophysiological effects of cisapride on cardiac action potential duration and ATP-sensitive K channel in papillary muscles. Methods : Cardiac action potentials in guinea pig papillary muscle were recorded with microelectrodes...
Effect of Fetal Cardiac Bypass on Fetal Cardiovascular System - Fetal Lamb Study -
Jung Yun Choi, June Huh, Yong Jin Kim, Won Gon Kim, Jeong Ryul Lee, Chong Sung Kim
Clin Exp Pediatr. 1999;42(7):943-952.   Published online July 15, 1999
Purpose : This study was aimed to evaluate the feasibility of echo-Doppler study on fetal lamb, analyse the distribution of blood flow before and after fetal cardiac bypass, and consequently assess the effect of fetal cardiac bypass on the fetal cardiovascular system. Methods : Ten fetal lambs at 120 to 150 days of gestation which underwent cardiac bypass for 30 minutes...
Clinical Analysis and Comparison of Kawasaki Disease between Patients Younger than One Year of Age and Those over One Year of Age
Hee-Sun Chung, Kyung-Yil Lee, Ji-Whan Han, Sang-Won Cha, Dong-Joon Lee, Kyung-Tai Whang
Clin Exp Pediatr. 1999;42(7):936-942.   Published online July 15, 1999
Purpose : To identify the risk factors for coronary sequelae in Kawasaki disease, we analyzed and compared the clinical features and laboratory findings of Kawasaki disease in patients younger than one year of age with those over one year of age. Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to the...
Survey of Harada Scoring of Occurrence of Coronary Aneurysm in Kawasaki Disease Compared to Current Criteria
Chang Kyu Nam, Yong Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1999;42(7):928-935.   Published online July 15, 1999
Purpose : Gamma-globulin is effective in preventing coronary aneurysm, the primary complication of Kawasaki disease(KD). However, in order to predict high-risk cases which absolutely require γ-globulin, because of its high expenses, Harada score(HS) was introduced in Japan in 1990. We attempted to compare HS scoring with the health insurance criteria currently used in Korea. Methods : Retrospective studies were performed on...
Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1999;42(7):921-927.   Published online July 15, 1999
Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord...
Antenatal Thyrotropin-Releasing Hormone to Prevent Respiratory Distress Syndrome in Preterm
Ai-Rhan Kim, Sung-Jong Park, Hye-Sun Yoon, Ki-Soo Kim, Hye-Sung Won, In-Sik Lee, Ahm Kim, Soo-Young Pi
Clin Exp Pediatr. 1999;42(7):911-920.   Published online July 15, 1999
Purpose : The purpose of this study was to assess the efficacy of antenatal thyrotropin-releasing hormone(TRH) given to mothers at risk for preterm delivery and assess various neonatal outcomes in infants born to these mothers. Methods : Sixty-one mothers(TRH＋Dexamethasone(D):30, D:31) with preterm labor at 26-34 weeks of gestational age were randomized into a study group which received 400μg of TRH at...
Characterization of Molecular Defects in Korean Families with Inherited Ornithine Transcarbamylase Deficiency and Their Genotype-Phenotype Correlations
Han-Wook Yoo
Clin Exp Pediatr. 1999;42(7):900-910.   Published online July 15, 1999
Purpose : This study was undertaken to characterize molecular defects in Korean families with ornithine transcarbamylase(OTC) deficiency, correlate it with phenotype using in vitro expression study, and utilize it for making prenatal molecular diagnosis. Methods : To investigate molecular lesions resulting in OTC deficiency in 15 unrelated Korean families, the OTC genes of probands were amplified exon by exon and analyzed...
Final Height in Idiopathic Growth Hormone(GH) Deficient Children Treated with GH
Byung Churl Lee
Clin Exp Pediatr. 1999;42(6):852-857.   Published online June 15, 1999
Purpose : Improved adult height is a major goal in the treatment of children with short stature due to GH deficiency(GHD). The purpose of this study was to evaluate final height in idiopathic GH deficient children after long-term GH treatment Methods : GHD was diagnosed in 9 male patients by at least two stimulation tests(maximum GH level≤5ng/ml). Other pituitary functions were...
Neonatal Hemolytic Diseases due to Minor Blood Group Isoimmunization; Analysis of Reported Cases in Korea
Je-Ho Jung, Gyo-Dang Koo, Chong-Woo Bae, Yong-Mook Choi, Hee-Joo Lee
Clin Exp Pediatr. 1999;42(6):844-851.   Published online June 15, 1999
Molecular Cloning and Characterization of ETV1 : a New Member of the ETS Family Transcription Factor that is Implicated in Ewing's sarcoma
In-sang Jeon, David N. Shapiro
Clin Exp Pediatr. 1999;42(6):833-843.   Published online June 15, 1999
Purpose : Ewing's sarcoma is characterized by accompanying specific chromosome translocations. In the present study, we report ETV1, the third member of the human ETS family that is implicated in Ewing's sarcoma by reciprocal translocation (7;22)(p22;q12). Methods : Primarily, cDNA library made from the Ewing's sarcoma cell line accompanying the t(7;22)(p22;q12) was screened using the 5' portion of EWS(including the...
Effects of Thioredoxin on Apoptosis-Inducing Neuronal Cell Injury
Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee
Clin Exp Pediatr. 1999;42(6):825-832.   Published online June 15, 1999
Purpose : Thioredoxin is an endogenous antioxidant. It regulates the activities of transcriptional factors such as NF-kB(nuclear factor kappa B)and AP-1(activator protein-1) and it increases the synthesis of cytokines, preventing cellular proliferation and apoptosis. The aim of this study was to clarify the role of thioredoxin on apoptosis-inducing neuronal cell injury. We investigated the protective effects of thioredoxin against apoptosis-inducing...
Renal Problems in Wilson Disease
Il Soo Ha, Jun Ho Lee, Yeon Ho Choe, Hae Il Cheong, Sei Won Yang, Young Yull Koh, Jeong Kee Seo, Yong Choi
Clin Exp Pediatr. 1999;42(6):817-824.   Published online June 15, 1999
Purpose : Wilson disease is a hereditary metabolic disorder characterized by an accumulation of copper in tissues which sometimes results in renal problems. This study was performed to evaluate the prevalences of the renal problems in Wilson disease and related risk factors. Methods : In 31 patients with Wilson disease, we looked for renal problems by history taking, physical examination...
Assessment of Regional Wall Motion of the Left Ventricle in Children with Congenital Heart Disease
Chang Hee Han, Jun Ho Huh, Un Seok Nho, Byung Ho Choi, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1999;42(6):807-816.   Published online June 15, 1999
Purpose : To assess wall motion of the left ventricle in the various forms of congenital heart disease and to select appropriate methods by which to gauge left ventricular wall motion. Methods : We evaluated left ventricular function, including volume, global ejection fraction, and regional wall motion(Centerline method, Local Ejection Fraction, Curved Perimeter method and Radial method). The evaluation was done...
Treatment of Pulmonary Atresia, Ventricular Septal Defect and Diminutive Pulmonary Arteries Comparing First Palliative Management Schemes
Jean Yoon, In Seung Park, Soo Jin Kim, Mi Young Han, Do Jun Cho, Eun Jung Bae, Young Tak Lee, Seong Ho Kim
Clin Exp Pediatr. 1999;42(6):800-806.   Published online June 15, 1999
Purpose : This report reviews an 8-year treatment of pulmonary atresia, ventricular septal defect and diminutive pulmonary arteries, comparing first palliative management schemes. Methods : Between January 1989 and March 1997, patients had their pulmonary artery anatomy evaluated before any surgical managements. Twenty-two patients had diminutive pulmonary arteries(Nakata index<90). Clinical records, hemodynamic data, and cineangiograms were examined in these patients. Results...
Doppler Echocardiographic Assessment of the Changes in Pulmonary Arterial Pressure in Preterm Infants with Respiratory Distress Syndrome
Sejung Sohn, Eun Ae Park
Clin Exp Pediatr. 1999;42(6):790-799.   Published online June 15, 1999
Purpose : The ratio of time to peak velocity(AT) and right ventricular ejection time(ET) as measured from the pulmonary artery Doppler waveform showed a close inverse correlation with pulmonary arterial pressure. The purpose of this study was to see the pattern of change in pulmonary arterial pressure assessed by AT/ET in preterm infants with respiratory distress syndrome (RDS). Methods : The...
Usefulness of the Flexible Bronchoscopy for Pediatric Respiratory Diseases
Chang Keun Kim, Churl Young Chung
Clin Exp Pediatr. 1999;42(6):783-789.   Published online June 15, 1999
Purpose : Flexible bronchoscopy is an important diagnostic and sometimes therapeutic tool that can be used on infants and children using light sedation and local anaesthesia. The purpose of this study is to evaluate the contribution of the flexible bronchoscopy to clinical diagnosis and therapy in children. Methods : We examined the first 100 consecutive flexible bronchoscopies performed in children under...
Effects of Hepatitis B Revaccination in Nonresponsive Children
Ui Chong Chong, Mi Ran Kim, Chong Young Park
Clin Exp Pediatr. 1999;42(6):778-782.   Published online June 15, 1999
Purpose : Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule. Methods :...
Immunogenicity of Haemophilus influenzae PRP-D Conjugate Vaccine in Korean Infants
Soo Young Choi, Hee Taek Kim, Yeon Woo Kim, Yun Jong Kang, Yeon Chung Chung, Jin Keun Chang, Hoan Jong Lee
Clin Exp Pediatr. 1999;42(6):771-777.   Published online June 15, 1999
Purpose : Infection by Haemophilus influenzae Type B(Hib) occurs most often in infants and children who are 5 years old and less. The incidence is highest around 6 months of age, and then decreases thereafter as infants gain natural immunity. Hi PRP-D conjugate vaccine is poorly immunogenic in infants. However, immunogenicity PRP-D vaccine in Korean infants is unknown. This...
Clinical Study of Aseptic Meningitis from 1996 to 1998 in Chounju Presbyterian Medical Center, Korea
Seung Woo Paik, Byoung Lae O, Sun Ja Cho, Young Taek Chang
Clin Exp Pediatr. 1999;42(6):765-770.   Published online June 15, 1999
Purpose : There was an explosive prevalence of aseptic meningitis for three years from 1996 to 1998. In this study, we reported the time of outbreak, clinical manifestation, CSF examination of patient, and CSF virus culture. Methods : We reviewed clinical records of 794 aseptic meningitis patient who had been admitted to Chounju Presbyterian Medical Center. The total number of patients...
The Percentiles of Body Mass Index and Trend of Obesity in Schoolage Children in Seoul
Min Ji Kim, Jin Seop Kang, Jae Wook Go, Young Jin Hong, Don Hee Ahn, Do Myung Paek, Yun Joo Kang, Sung Jae Suh
Clin Exp Pediatr. 1999;42(6):756-764.   Published online June 15, 1999
Purpose : Many authors have reported that obesity is a serious health problem in schoolage children and adolescents and recently obese children are increasing. Accurate diagnosis is needed to estimate the prevalence rate and trend of obesity. We studied body mass index(BMI) percentile for age and sex as a reliable and valid screening for adiposity. Methods : We measured...
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