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Original Article
Clinical Analysis of Scrotal Involvement in Childhood Henoch-Schönlein Purpura
Jin-Seok Lee, Tae-Sun Ha
Clin Exp Pediatr. 2004;47(10):1093-1099.   Published online October 15, 2004
Purpose : Henoch-Schönlein purpura(HSP) is a systemic vasculitis affecting predominantly skin, the gastrointestinal tract, the joints and kidneys. Because the scrotal manifestations including swelling and pain (or tenderness) are known to be uncommon in male HSP patients, there has been a little mention of them in the studies of HSP. Therefore, we investigated the clinical and laboratory features of HSP...
The Levels of Zinc and Neuron-specific Enolase in Febrile Convulsion
Hong Sang Cho, Jun Hun Shin, Ji Yeoung Seo, Cho Ae Lee, Se Hyun Kim, Kyu Young Chae
Clin Exp Pediatr. 2004;47(10):1087-1092.   Published online October 15, 2004
Purpose : To determine the role of zinc in febrile convulsion and to evaluate whether febrile convulsion causes neuronal damage, serum and cerebrospinal fluid(CSF), zinc and CSF neuron-specific enolase(NSE) levels were measured in patients with febrile convulsion, epilepsy and aseptic meningitis. Methods : Three groups were formed as follows : group I : 53 children with febrile convulsion; group II :...
Characteristics of Developmentally Delayed Infants and Young Children Who Demonstrated Normal Myelination by Brain MRI
Young Se Kwon, Yong Hoon Jun, Young Jin Hong, Byong Kwan Son, Kyoung Hee Lee
Clin Exp Pediatr. 2004;47(10):1081-1086.   Published online October 15, 2004
Purpose : To evaluate the clinical characteristics of infants and young children who had developmental delay without delayed myelination and dysmyelination. Methods : We retrospectively reviewed 59 cases of developmental disability between July 1996 and June 2001 at Inha University Hospital. Twenty-eight patients showed normal myelination(Group I), while thirty-one patients showed delayed myelination(Group II) by brain MRI. The following clinical records...
Pulmonary Function of Patients with Adolescent Idiopathic Scoliosis
Yu Sok Han, Hyun Ah Kim, Uee Ryoung Chung
Clin Exp Pediatr. 2004;47(10):1076-1080.   Published online October 15, 2004
Purpose : To evaluate the patterns of preoperative pulmonary function tests(PFTs) and their correlation with postoperative pulmonary impairment in patients with adolescent idiopathic scoliosis(AIS), who had orthopaedic operation with or without rib resection thoracoplasty. Methods : The case records and radiographs of 79 patients(12, boys and 67, girls) of a mean age of 13.3 years(7-15 years) with AIS who underwent orthopaedic...
A Study of Group B Streptococcal Infection in Pregnant Women, by LIM Broth Media
Tae Hyung Kim, Su Eun Park, Ki Hyung Kim
Clin Exp Pediatr. 2004;47(10):1072-1075.   Published online October 15, 2004
Purpose : To evaluate the degree of Group B streptococcal colonization in Korean pregnant women of gestational age 35-37 weeks. Methods : From May 1, 2002 to April 30, 2003, the medical records of 53 pregnant(gestational age from 35 to 37 weeks) women who visited the department of Ob & Gyn, Pusan National Hospital for antenatal care, were reviewed. By use...
Causative Organisms of Urinary Tract Infection in Children, and their Antibiotic Susceptibility
Yoon Duk Kang, Nam Su Kim, Sung Hee Oh
Clin Exp Pediatr. 2004;47(10):1065-1071.   Published online October 15, 2004
Purpose : In caring patients with urinary tract infection(UTI), it is prominent to know causative agents and their antimicrobial susceptibilities, of which domestic data appear somewhat different from those reported in the literature. The study was done to learn the distribution of pathogens causing UTI and their antimicrobial susceptibilities in Korean children. Methods : One hundred forty two inpatients diagnosed...
A Clinical Study of Sepsis with Thrombocytopenia in Premature Infants
Jae Hoon Sim, So Ick Jang, Yun Jung Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo
Clin Exp Pediatr. 2004;47(10):1058-1064.   Published online October 15, 2004
Purpose : This study was performed to characterize sepsis with thrombocytopenia in premature infants to determine if thrombocytopenia is a prognostic factor in sepsis in premature infants. Methods : We retrospectively analyzed the medical records of sepsis in premature infants admitted to the neonatal intensive care unit(N=41) at the Hallym University Sacred Heart Hospital from January 1999 to December 2002. The...
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Risk of Down Syndrome
Kyu Young Chae, Jin Hee Han, Ji Yeong Seo, Min Jung Cho, Sehyun Kim, Nam Keun Kim
Clin Exp Pediatr. 2004;47(10):1053-1057.   Published online October 15, 2004
Purpose : The C677T polymorphism of the methylenetetrahydrofolate reductase(MTHFR) has been suggested as a risk factor of maternal meiotic nondisjunction for Down syndrome. Recently, a second genetic polymorphism in MTHFR at position 1298 was reported. However, a positive association between the A1298C MTHFR polymorphism and Down syndrome has not been reported. Therefore, this study was undertaken to determine which polymorphism...
Quantification of Organic Acids in Amniotic Fluid for Prenatal Diagnosis of Organic Acidemia
Chang Bum Koh, Dong Soo Shin, Eun Joo Bae, Won Il Park, Kyeung Ja Lee, Hong Jin Lee, Young Jo, Seung Won Lee, Ui Sun Noh
Clin Exp Pediatr. 2004;47(10):1047-1052.   Published online October 15, 2004
Purpose : Since 1997, the quantification of organic acids in urine has become possible in Korea. This helped to diagnose a great variety of inborn errors of metabolism. However, we still don't know the normal value of organic acids in amniotic fluid, therefore it is impossible for doctors to make a correct diagnosis of inborn errors of metabolism in prenatal...
Iron Deficiency Anemia and Iron Nutrition in Adolescent Female Athletes
Yang Kyong Kim, Bo Young Kang, Young Jin Hong, Byong Kwan Son, Kwang Hoi Kim, Soon Ki Kim
Clin Exp Pediatr. 2004;47(10):1041-1046.   Published online October 15, 2004
Purpose : Iron deficiency, particularly iron deficiency anemia(IDA) often not only decreases athletic performance but also impairs immune function and leads to other physiologic dysfunctions. This study was designed to assess and compare iron status and the IDA prevalence in female adolescent athletes with those of general adolescent students. Methods : Physical measurements and hematologic examinations were performed for adolescent...
Synergistic Cytotoxicity of Arsenic Trioxide and Sulindac Against Neuroblastoma
Du Young Choi
Clin Exp Pediatr. 2004;47(9):1002-1007.   Published online September 15, 2004
Purpose : Recent clinical studies have shown that arsenic trioxide(As2O3) at low concentrations induces complete remission without significant toxicity in patients with refractory acute promyelocytic leukemia(APL). Like APL cells, neuroblastoma(NB) cells are thought to be arrested at an early stage of differentiation, and can respond with retinoic acid treatment. Sulindac, a nonsteroidal antiinflammatory drug, was reported to induce antitumor activity...
Febrile Seizure-induced Neuroexcitability in Immature Rat Hipocampus
Bong Keun Choi, Kyu Geun Hwang, Hae Rahn Bae
Clin Exp Pediatr. 2004;47(9):992-1001.   Published online September 15, 2004
Purpose : To determine whether febrile seizure enhances neuroexcitability by altering synaptic transmission and whether febrile seizure-induced hyperexcitability leads to long-lasting neuronal death. Methods : We investigated the expression of synaptic and postsynaptic proteins and the apoptosis of neuronal cells in rat pup hippocampus after hyperthermic seizure using immunoblotting and confocal microscopy. Results : Hyperthermic seizure enhanced the long-term expressions of...
Elevated Circulating ICAM-1 and Eosinophil Cationic Protein in Children with Chronic Urticaria
You Sun Choi, Su A Shin, Young Dai Kim, Jae Won Oh, Ha Baik Lee
Clin Exp Pediatr. 2004;47(9):986-991.   Published online September 15, 2004
Purpose : Chronic urticaria is characterized by recurrent, itchy, and evanescent wheals over a period of six weeks. The mechanisms of chronic urticaria in children have not been fully elucidated. However, urticaria lesions represent a dynamic inflammatory process involving a complex interplay of various inflammatory mediators, chemokines, adhesion molecules and cellular interaction. The aim of this investigation was to elucidate...
Neurologic Complications after Hematopoietic Stem Cell Transplantation in Children
Moon Young Jeong, Young Kuk Cho, So Youn Kim, Young Ok Kim, Chan Jong Kim, Hoon Kook, Young Jong Woo, Tai Ju Hwang
Clin Exp Pediatr. 2004;47(9):978-985.   Published online September 15, 2004
Purpose : Neurologic complications(NC) after hematopoietic stem cell transplantation(HSCT) are important because of high mortality and severe sequelae. We analyzed the incidence, manifestation and risk factors of NC in 61 children undergoing HSCT. Methods : We retrospectively analyzed NC in 61 cases(42 male and 19 female, aged one to 16 years) given HSCT between 1996 and 2003 due to hematologic malignacies,...
Factors Affecting the Increments of Body Mass Index in Adult Survivors of Childhood Brain Tumors
Jae Ho Yoo, Sung Yeon Ahn, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2004;47(9):970-977.   Published online September 15, 2004
Purpose : The purpose of this study was to evaluate the factors affecting the increments of body mass index(BMI) in adult survivors from childhood brain tumors. Methods : We retrospectively reviewed medical records of 63 patients who were diagnosed with brain tumors and treated at Seoul National University Children's Hospital between 1982 and 2000. We evaluated the factors affecting adult BMI(aBMI)...
Effects of the Chronic Use of Anticonvulsants on Bone Mineral Density in Children with Epilepsy
Hyun Hee Oh, You Cheol Jang, Byung Ho Choe, Il Hyung Park, Soon Hak Kwon
Clin Exp Pediatr. 2004;47(9):965-969.   Published online September 15, 2004
Purpose : Chronic administration of anticonvulsants for children with epilepsy may cause multiple abnormalities in bone metabolism. The aim of this study was to evaluate the effects of anticonvulsants on bone mineral density(BMD) in children with epilepsy. Methods : Seventy patients with epilepsy were enrolled in this study. All subjects had taken anticonvulsants for at least 1 year or more....
Assessment of Cardiac Function in Neonates by Using Tissue Doppler Imaging
Hee Chul Yoon, Jae Hoon Choe, Sun Young Kim, In Kyu Lee, Myung Ho Oh
Clin Exp Pediatr. 2004;47(9):959-964.   Published online September 15, 2004
Purpose : Tissue Doppler imaging(TDI) is recently being used for assessement of regional ventricular function in adults. However, data in neonates have not been established yet. The aim of this study is to establish reference values of TDI velocities and to investigate the effect of other factors on TDI velocites in the neonatal population. Methods : Forty eight healthy neonates with...
The Efficacy of Nebulized Epinephrine Versus Fenoterol in Hospitalized Infants with Acute Bronchiolitis
Sang Hee Lee, Kyung Ah Nam, Ji Youn Choi, Meen Jung Kim, Son Sang Seo
Clin Exp Pediatr. 2004;47(9):953-958.   Published online September 15, 2004
Purpose : Acute bronchiolitis is a lower respiratory tract disease, resulting from inflammatory obstruction of the small airway. The main treatment of acute bronchiolitis is supportive but, numerous investigators have examined the efficacy of beta agonist as bronchodilators. In acute bronchiolitis, mucosal edema in the bronchioles may be an important cause of airway obstruction therefore, an alpha and beta agonist...
A Comparison of Clinical Manifestations in Neonates and Infants Infected by Respiratory Syncytial Virus
In Suk Lim, Min Joo Shim, Byung Eui Kim, Ju Young Chung, Chang Keun Kim, Myoung Jae Chey, Sang Woo Kim, Soung Hee Kim, Tae Hee Han
Clin Exp Pediatr. 2004;47(9):949-952.   Published online September 15, 2004
Purpose : This study was performed to evaluate of clinical manifestations of neonatal respiratory syncytial virus(RSV) infection, and to evaluate of differences of clinical manifestations between the neonates and infants who were infected by RSV. Methods : We reviewed the medical record of 75 children who were younger than 12 months of age and infected by RSV. We classified then into...
Surfactant Therapy for Neonatal Respiratory Distress Syndrome : Experience in Korea Over 15 Years
Chong-Woo Bae, Young-Min Kim
Clin Exp Pediatr. 2004;47(9):940-948.   Published online September 15, 2004
Purpose : Surfactant replacement therapy in neonates with respiratory distress syndrome(RDS) has been used in Korea since 1990. We undertook a collective study of trials from multi-hospitals to evaluate results of neonates with RDS who were treated with surfactant during the past 15 years in Korea(Period I, P-I, 1990-91; Period II, P-II, 1996; Period-III, P-III; 2002). Methods : There were 60...
Utilization Patterns of Medical Care of Elementary School Children after the Implementation of Medical Reform : Comparison with a Previous Study in 1998
Eun Seok Yang, Mi Jin Kim, Eun Young Kim, Young Il Rho, Sang Kee Park, Yeong Bong Park, Kyung Rye Moon
Clin Exp Pediatr. 2004;47(9):933-939.   Published online September 15, 2004
Objective : The purpose of this study was to assess the patterns of medical care utilization and factors which determine medical care utilization of elementary school children after the implementation of medical reform. Methods : We performed the questionnaires on 1,031 children from two elementary schools in Gwangju city from June 1 to 30 June, 2001. These data were compared with...
The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(8):884-891.   Published online August 15, 2004
Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in...
Clinical Characteristics of Recurrent Kawasaki Disease
Hyun Ji Lee, Ae Ra Cho, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2004;47(8):879-883.   Published online August 15, 2004
Purpose : The purpose of this study is to investigate the clinical manifestations and the risk factors of recurrent Kawasaki disease(KD). Methods : From March 1995 to June 2003, 14 children with recurrent KD in Ewha Womans University Hospital were retrospectively evaluated by reviewing their admission reports. The clinical characteristics, laboratory findings, treatment and complications of the recurrent KD group were...
Bronchial Hyperresponsiveness and Atopy in 6-8 Year Old Children According to the History of Wheezing in Early Childhood
Jinho Yu, Young Yoo, Hee Kang, Young Yull Koh
Clin Exp Pediatr. 2004;47(8):873-878.   Published online August 15, 2004
Purpose : It is becoming generally recognized that wheezing in early childhood is a heterogeneous condition and does not always develop into asthma. This study aimed to determine characteristics of wheezing phenotypes in early childhood and investigate their relation to asthma. Methods : Two hundreds and sixty 6-8 year old children with past or present wheezeing were enrolled, and their history...
Analysis and Evaluation of the Reliability of Medical Information on Food Allergies on the Internet
Young Bun Cho, Young Shin Yoon, Ji Yeon Chang, Sun Mi Kim, Kwi Sook Kim, Chang Hee Choi
Clin Exp Pediatr. 2004;47(8):868-872.   Published online August 15, 2004

Purpose: The information in the internet is increasing and the number of people using the Internet to obtain medical information is increasing rapidly too. But, compared to the amount of information, the quality of information is extremely variable. To assess the accuracy of medical information on the Internet, the quality of information about food allergies available on the internet examined. Methods:...
Follow-up Studies and Clinical Significance of Chromosomal Rearrangement in Childhood Acute Lymphocytic Leukemia
Yang Hyun Kim, Jung Tae Kim, Jung Chul Kang, Hae Sik Kwon, Sung Chul Won, Seung Hwan Oh, Chuhl Joo Lyu
Clin Exp Pediatr. 2004;47(8):861-867.   Published online August 15, 2004
Purpose : Through routine screening for chromosomal defects present in patients with acute lymphocytic leukemia(ALL) by means of reverse transcription-polymerase chain reaction(RT-PCR), we aimed for earlier detection of recurrences, hence evaluating the progress of the disease after treatment, and forecasting the need for further testing. Methods : We analyzed 30 patients who visited the Pediatrics Department of Severance Hospital, from...
Clinical Study of Benign Convulsion with Acute Gastroenteritis
Jin Hyung Cho, Kim Eun Joo, Sung Koo Kim, Seon Hee Shin, Kon Hee Lee, Hae Sun Yoon
Clin Exp Pediatr. 2004;47(8):855-860.   Published online August 15, 2004
Purpose : This study was performed to characterize clinical features of benign convulsions with acute gastroenteritis(CwG) in infants. Methods : We reviewed 83 consecutive seizures in 42 patients with CwG between January 1995 and December 2003. CwG was defined as convulsions having the following two characteristics : (a) seizures accompanied with symptoms of gastroenteritis without clinical signs of dehydration or electrolyte...
The Diagnostic Value of Gross Bloody Stool on Intussusception
Kyung Ah Nam, Sang Hee Lee, Sang Hee Son, Su Jin Jung, Son Sang Seo
Clin Exp Pediatr. 2004;47(8):851-854.   Published online August 15, 2004
Purpose : To evaluate the diagnostic value of gross bloody stools as a predictor of intussusception. Methods : We reviewed 159 cases retrospectively that had an ultrasound examination for diagnosis of intussusception from January 2001 to December 2003 at Ilsin Christian Hospital. We compared each symptom and assessed the diagnostic value of gross bloody stools in the patients with suspected intussusception. Results...
A Clinical Study of Infective Endocarditis in Childhood
Eun Na Choi, Jae Hun Kwon, Kyong Min Choi, Hwan Dae Hwang, Kyoung Mi Sin, Jae Young Choi, Jun Hee Sul, Dong Su Kim
Clin Exp Pediatr. 2004;47(8):844-850.   Published online August 15, 2004
Purpose : Advances in the treatment of congenital heart disease and a decline in the incidence of rheumatic fever has led to changes in the causative organisms and the clinical outcome of infective endocarditis(IE). We sought to analyze the clinical outcome, prognostic factors, causative organisms and corresponding antibiotic sensitivity in IE. Methods : Retrospective analysis of medical records of 104 children...
Protein C as a Differential Marker for Bacterial Infection among Pediatric Patients with Fever
Eun Ha Mo, In Hae Nam, Kyung Duk Park
Clin Exp Pediatr. 2004;47(8):839-843.   Published online August 15, 2004
Purpose : This study was performed to find the clinical significance in protein C as a differential marker in the beginning stage of infection and prognosis factor in severe infection among pediatric patients who were admitted due to fever. Methods : A total of 40 pediatric patients who had temperatures higher than 37.5℃ on admission at the Department of Pediatrics,...
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