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Original Article
Sensitization rates of airborne pollen and mold in children
So Hyun Park, Dae Hyun Lim, Byong Kwan Son, Jeong Hee Kim, Young Eun Song, In Bo Oh, Yang Ho Kim, Keun Hwa Lee, Su Young Kim, Sung Chul Hong
Clin Exp Pediatr. 2012;55(9):322-329.   Published online September 14, 2012

Aeroallergens are important causative factors of allergic diseases. Previous studies on aeroallergen sensitization rates investigated patients groups that had visited pediatric allergy clinics. In contrast, we investigated sensitization rates in a general population group of elementary school to teenage students in Incheon, Jeju, and Ulsan.


After obtaining parental consent, skin-prick tests were performed on 5,094 students between March and June 2010....

Comparison of air pollution and the prevalence of allergy-related diseases in Incheon and Jeju City
Su Ho Jeong, Jeong Hee Kim, Byong Kwan Son, Seong Chul Hong, Su Young Kim, Geun Hwa Lee, Dae Hyun Lim
Clin Exp Pediatr. 2011;54(12):501-506.   Published online December 31, 2011

A high level of air pollutants can increase the number of patients with allergy-related diseases such as asthma and allergic rhinitis (AR). To analyze the association between air pollution and allergic disease, we investigated 2 areas in Korea: Incheon, an industrial area, and Jeju, a non-industrialized area.


Second grade students at elementary schools (11 schools in Incheon and 45 schools in...

Comparison between adverse effects of low and usual doses of intravenous aminophylline
Bok Ki Kim, Dae Hyun Lim, So Hyun Ahn, Jong Hoon Kwa, Jeong Hee Kim, Byong Kwan Son
Clin Exp Pediatr. 2009;52(4):441-445.   Published online April 15, 2009
Purpose : Some patients develop side effects from theophylline even at low serum concentrations. We designed a prospective study to evaluate the side effects of theophylline. Methods : A Prospective, controlled trial study was conducted. The low-dose group received an intravenous continuous aminophylline dose of 5 mg/kg/day on the first day and subsequently 10 mg/kg/day on the following two days....
Review Article
Epidemiology of anaphylaxis in Korean children
Dae Hyun Lim
Clin Exp Pediatr. 2008;51(4):351-354.   Published online April 15, 2008
Anaphylaxis is an acute systemic reaction caused by IgE-mediated immunological release of mediators from mast cells and basophils to allergenic triggers, such as food, insect venoms, and medications. An alternative definition was recently proposed as follows: anaphylaxis is a "condition caused by an IgE mediated reaction" that is "often life threatening and almost always unanticipated." The reaction can be severe enough to lead...
Allergic skin test
Byong Kwan Son, Dae Hyun Lim
Clin Exp Pediatr. 2007;50(5):409-415.   Published online May 15, 2007
Allergy skin prick test and intradermal test represent one of the major tools in the diagnosis of IgE- mediated diseases like as atopic asthma, allergic rhinitis, atopic dermatitis, food and drug allergy, and insect bite when properly performed. Skin tests are of particular importance in fields such as allergen standardization, pharmacology, and epidemiology. Even if skin tests seem easy to...
Case Report
A case of acquired acrodermatitis enteropathica with a normal serum zinc level but a low level in the hair
Kyung Il Oh, Jung Hee Kim, Ji Eun Lee, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 2007;50(2):209-212.   Published online February 15, 2007
Acrodermatitis enteropathica (AE) is a rare autosomal recessive disorder of early infancy, and is characterized by periorificial dermatitis, alopecia, and intractable diarrhea. Serum zinc levels are usually low in untreated patients and the oral administration of zinc sulfate can clear skin lesions and other symptoms. Although premature and cow`s milk-fed infants are at particular risk of developing AE, there have...
Clinical Lecture
Airway Remodelling in Asthma
Dae Hyun Lim
Clin Exp Pediatr. 2005;48(10):1038-1049.   Published online October 15, 2005
Asthma is characterized by a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodelling. Characteristic changes of airway remodelling in asthma include goblet cell hyperplasia, deposition of collagens in the basement membrane, increased number and size of microvessels, hypertrophy and hyperplasia of airway smooth muscle, and hypertrophy of submucosal glands....
Case Report
A Case of Systemic Sclerosis in a Child
Ji Yeon Chang, Ja Kyoung Kim, Jeong Hee Kim, Dae Hyun Lim, Byong Kwan Son, Jung Soo Song
Clin Exp Pediatr. 2004;47(2):214-216.   Published online February 15, 2004
Systemic sclerosis is a connective tissue disease involving primarily the skin and subcutaneous tissue but may involve other organ systems such as the lungs, gastrointestinal tract, and heart. Systemic sclerosis is a rare childhood disease. The age of onset for patients with systemic sclerosis has its peak between 30 and 50 years of age. Only 1 to 2% of all...
Original Article
The Efficacy of Proximal Esophageal 24-hour pH Monitoring in Infants with Chronic Cough
Yun Hee Kim, Ja Kyoung Kim, Jung Hee Kim, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 2003;46(12):1242-1247.   Published online December 15, 2003
Purpose : Gastroesophageal reflux disease(GERD) is known as one of the most common causes of chronic cough, especially in children. The purpose of this study is to evaluate the efficacy of parameters from proximal esophageal 24-hr pH monitoring through its comparison with those of distal esophageal 24-hr pH monitoring that we generally use for diagnosis of GERD. Methods : We performed...
Case Report
A Case of Centronuclear Myopathy
Yun Hee Kim, Yun Hee Kim, Young Se Kwon, Young Se Kwon, Dae Hyun Lim, Dae Hyun Lim, Yong Hun Jun, Yong Hun Jun, Soon Ki Kim, Soon Ki Kim, Young Jin Hong, Young Jin Hong, Byong Kwan Son, Byong Kwan Son, Hae Seung Han, Hea Seung Han
Clin Exp Pediatr. 2002;45(9):1170-1174.   Published online September 15, 2002
Centrinuclear myopathy, an uncommon condition, is one of the congenital myopathies. It is characterized by the presence of central nuclei of muscle cells which can be detected on electronmicroscopy. It is believed to arise as a result of maturational arrest with persistence of microtubes postnatally. We report a boy with generalized hypotonia and muscle weakness who was diagnosed as centrinuclear...
A Case of Partial DiGeorge Syndrome in Prematurity
Tae Jung Sung, Eun Young Ko, Dal Hyon Kim, Ji Eun Oh, Young Se Kwon, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 2002;45(3):383-389.   Published online March 15, 2002
We experienced a case of partial DiGeorge syndrome in a 35+5 week premature female infant presented with micrognathia, fish-shaped mouth, beaked nose, nasal regurgitation, obstructive sleep apnea, velopharyngeal insufficiency and late onset hypocalcemic seizures. The chromosome 22q11 microdeletion was found by the FISH method. The lab findings showed serum calcium level of 4.4 mg/dL, ionized calcium level of 0.49 mg/dL,...
Original Article
Usefulness of Chest High-Resolution CT in Patients with Chronic Cough Below 2 Years of Age
Myung Hyun Kim, Jung Hee Kim, Dae Hyun Lim, Byong Kwan Son, Kyung-Hee Lee
Clin Exp Pediatr. 2002;45(3):339-345.   Published online March 15, 2002
Purpose : The purpose of this study was to evaluate the clinical usefulness of chest high-resolution computed tomography(HRCT) in patients with chronic coughs or persistent wheezing with normal chest X-ray finding. Methods : We reviewed the charts, chest X-rays, and HRCT findings of patients with chronic coughs or persistent wheezing of less than 2 years of age. The records were sourced...
Study on the Interrelationship of Air Pollution and Respiratory Diseases in Inchon City Via Children Who Visited the Emergency Room of Inha University Hospital
Hyun Choi, Dae Hyun Lim, Jung Hee Kim, Byong Kwan Son, Jong Whan Lim, Youn Chol Hong
Clin Exp Pediatr. 2000;43(10):1372-1379.   Published online October 15, 2000
Purpose : It is generally accepted that air pollution can cause acute respiratory diseases. This study assessed the relationship between air pollution and development of pediatric respiratory diseases in Inchon city. Methods : We studied a number of pediatric patients who developed respiratory diseases such as bronchial asthma, bronchiolitis, URI, bronchitis and pneumonia and visited the Inha University Hospital emergency room...
Case Report
A Case of Fixed Drug Eruption Due to Acetaminophen
Eui Jeong Min, Dae Hyun Lim, Jung Hee Kim, Seung Won Choi, Byong Kwan Son
Clin Exp Pediatr. 2000;43(8):1149-1152.   Published online August 15, 2000
Fixed drug eruption normally presents as single or multiple sharply demarcated erythematous lesions that recur at the same location upon re-exposure to the offending agent. When the acute inflammation subsides, it often leaves residual hyperpigmentation. Commonly implicated substances are phenolphthalein, barbiturates, sulfonamides, tetracyclines, salicylates, gold and pyrazolone derivatives. Despite frequent use of acetaminophen, drug eruptions, especially fixed drug eruptions, due...
Original Article
Tuberculin Response in Infants after BCG Vaccination during Neonatal Stage
Jeong Hee Kim, Dae Hyun Lim, Byung Kwan Son, Sei Woo Chung,, Jeong Gyu Kim, Seung Yeon Nam, Sang Il Lee, Jin A Son
Clin Exp Pediatr. 1999;42(11):1502-1507.   Published online November 15, 1999
Purpose : Mantoux test was widely used to identify the tuberculosis. But no reliable method exists for distinguishing tuberculin reactions caused by previous BCG vaccination from those caused by mycobacterial infections. So we studied Mantoux response in infants who had received BCG vaccination in the first month of life. Methods : Mantoux testing was carried out in 143 healthy infants...
The Relation of Food-Specific IgE to Recurrent Wheezing Attack
Yun Jeong Yang, Jeong Hee Kim, Yoo Mee Choi, Dae Hyun Lim, Sei Woo Chung, Jeong Gyu Kim, Byong Kwan Son
Clin Exp Pediatr. 1999;42(8):1056-1062.   Published online August 15, 1999
Purpose : There were some reports that IgE-mediated food hypersensitivity is associated with subsequent development of atopic disease in wheezy infants. So we carried out this study to show whether the food specific IgE antibodies are useful to predict recurrent wheezing attack in wheezy infants. Methods : A total of 190 children younger than 4-year-old were enrolled in this study. They...
Case Report
A Case of Idiopathic Pulmonary Hemosiderosis Improved with Steroid Inhalation
Young Se Kwon, Jeong Hee Kim, Dae Hyun Lim, Soon Ki Kim, Sei Woo Chung, Byong Kwan Son
Clin Exp Pediatr. 1998;41(8):1153-1156.   Published online August 15, 1998
Original Article
Use of Erythema as An Interpreting Index of the Skin Prick Test
Ji Eun Lee, Jeong Hee Kim, Dae Hyun Lim, Sei Woo Chung, Byong Kwan Son
Clin Exp Pediatr. 1998;41(7):966-973.   Published online July 15, 1998
Purpose : There are many methods to interpret the skin prick test which has been commonly used to find out the causative allergen in allergic disease. Among them two are most frequently used. One is to measure the absolute size of wheal which is caused by the allergen and the other is to compare the size of wheal for allergen...
Influences of the Intrapulmonary R→L Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome
Yoon Hyung Park, Sei Woo Chung, Seung Baik Han, Young Se Kwon, Ji Youn Kim, Woo Sik Cheong, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 1997;40(11):1508-1519.   Published online November 15, 1997
Purpose : We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth. Methods : From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit...
Normal Predicted Value of Airway Resistance by Flow Interrupter Technique in Korean Primary School-Aged Children
Byong Kwan Son, Dae Hyun Lim, Jeong Hee Kim, Jong Woon Choi, Soon Ki Kim, Sei Woo Chung
Clin Exp Pediatr. 1996;39(8):1095-1102.   Published online August 15, 1996
Purpose : To get the normal predicted value of airway resistance in Korean primary school-aged children by using flow interrupter technique which is simple and easy enough to be applicable even to young children. Methods : Among all the children of one primary school, we selected 964 (Male 469, Female 495). Excluded children were out of normal range in growth with Korean standard and/or...
The Effect of Alfacalcidol in the Treatment of Idiopathic Myelofibrosis in Children
Soon Ki Kim, Jeong Hee Kim, Dae Hyun Lim, Jong Woon Choi, Byong Kwan Son, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(3):339-346.   Published online March 15, 1994
Idiopathic myelofibrosis (IMF), which is characterized by marrow fibrosis, leukoerythroblastic anemia, teardrop poikilocytosis and splenomegaly due to extramedullary hematopoiesis, has known to have no form of therapy. On the ground of the possibility of reversing collagen deposition in IMF using 1, 25-dihydroxycholecalciferol [1, 25(OH)2D3], we report here our observations of 5 patients (M:F = 1:4) with IMF before and after treatment...
Normal Predicted values of Pulmonary function Test in Korean Primary School-Aged Children
Dae Hyun Lim, Jeong Hee Kim, Jun Hee Park, Jong Woon Choi, Soon Ki Kim, Byong Kwan Son
Clin Exp Pediatr. 1994;37(2):240-249.   Published online February 15, 1994
Pulmonary function test is one of the most important tools in the management of patients with respiratory tract diseases and allergic diseases. As with the difficulties in performing the test, it has been seldom used in pediatric field. But with the advent of simple, computerized tools, pediatric pulmonologist and allergist try to manage the patients using PFE. Still the normal...
The Incidence of Allergic Disease among the Pediatric Outpatient
Jeong Hee Kim, Jun Hee Park, Dae Hyun Lim, Soon Ki Kim, Byong Kwan Son
Clin Exp Pediatr. 1994;37(1):9-18.   Published online January 15, 1994
The incidence of allergic disease in pediatric outpatient department of a hospital, where primary care is undertaking, was studied from Arp. 1, 1989 to Mar. 32, 1990. The results were as follows, 1) The incidence of respiratory tract disease was the highest with the value of 57.2% of the total patients, followsed by gastrointestinal tract disease (13.9%), infectious disease (6.7%), visit...
A Case of Estrogen-producing Sertoli-Leydig Cell Tumor with Precocious puberty.
Myung Sun Oh, Nan Kyoung Kim, Dae Hyun LIm, Jeung Hee Kim, Byong Kwan Son, In Suk Joo, Ku Sang Kim, Young Chai Joo
Clin Exp Pediatr. 1990;33(9):1301-1305.   Published online September 30, 1990
We have experienced a case of estrogen producing Sertoli-Leydig cell tumor with precocious puberty in a 2-year-old girl. Her chief complaints were breast enlargement, which was noticed 20 days prior to admission and vaginal bleeding, which was noticed 10 days prior to admission. The diagnosis was made on the basis of history, physical examination, ultra sonography, hormonal study, and histologic study after operation. She was...
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