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- Original Article
- A Cost-benefit Analysis on Neonatal Screening of Phenylketonuria and Congenital Hypothyroidism in Korea
- Hoe Cheol Yoon, Nyeon Cheon Kim, Dong Hwan Lee
- Clin Exp Pediatr. 2005;48(4):369-375. Published online April 15, 2005
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Purpose : Many inborn errors of metabolism can be completely cured with early detection and early treatment. This is why neonatal screening on inborn errors of metabolism is implemented worldwide. In this study, a cost-benefit analysis was performed on the neonatal screening of phenylketonuria and congenital hypothyroidism in Korea. Methods : This study included 2,908,231 neonates who took the neonatal screening... -
- Clinical Lecture
- Clinical Approach to the Children with Coagulation Deficiencies
- Sang Kyu Park
- Clin Exp Pediatr. 2004;47(10):1036-1040. Published online October 15, 2004
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This review deals with the coagulation deficiencies which are due to the abnormality in one of three hemostatic systems. It explains about the diagnostic examinations that should be done to differentiate for patients with bleeding tendency and the things to consider when preoperative screening tests for coagulation are abnormal. -
- Original Article
- Screening Test for Heart Diseases in the First Grade Elementary School Children in Busan
- Jae Min Oh, Hee Ju Park
- Clin Exp Pediatr. 2003;46(5):490-494. Published online May 15, 2003
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Purpose : We'd like to determine the incidence of congenital heart disease and arrhythmia in elementary school children in Busan, and to provide adequate prevention and treatment. Methods : A total of 23,802(male 12,909, female 10,893) 1st grade elementary school children living in Busan were studied. All children were 7-8 years old. We obtained their medical history by questionnaire and checked... -
- The Ewha Infant Develomental Screening Test
- Keun Lee
- Clin Exp Pediatr. 2002;45(6):700-711. Published online June 15, 2002
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Purpose : Early identification and treatment of developmental disabilities is of considerable importance in the health care of children. Screening of development is aimed at identifying infants who may need more comprehensive evaluations. Methods : A new test, the Ewha Infant Development Screening Test(EDST) has been created to screen the development of infants, 0-4 years of age. EDST was constructed so... -
- Development of a Screening Kit for Early Diagnosis and Prevention of Wilson`s Disease
- Sihoun Hahn, Soo-Young Lee, Young-Ju Jang, Soon-Nam Kim, Ha-Cheol Shin, Sun-Young Park, Joo-Hyoung Kang, Eun-Sun You
- Clin Exp Pediatr. 2001;44(12):1374-1380. Published online December 15, 2001
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Purpose : Wilson`s disease is an autosomal recessive disorder characterized by copper accumulation in the liver, brain, and other organs due to defected copper metabolism. The incidence of Wilson`s disease is approximately one in 30,000 population in the world, more common than phenylketonuria in Korea. The early diagnosis or presymptomatic diagnosis of Wilson`s disease is critical in order for them... -
- Nitroblue Tetrazolium(NBT) Test as a Screening Test of Urinary Tract Infection in Children
- Nyun Huh, Chang Hee Oh, Je Woo Kim, Phil Soo Oh, Hae Sun Yoon, Won Keun Song
- Clin Exp Pediatr. 2001;44(10):1157-1161. Published online October 15, 2001
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Purpose : It has been reported that the Nitroblue Tetrazolium(NBT) test is more accurate than the urine pH, leukocyte esterase and nitrite test as a screening test of urinary tract infection (UTI). The purpose of this study is to compare the NBT test with other screening tests and evaluate the clinical usefulness of the NBT test as a screening test. Methods... -
- Effectiveness of Polaroid Photoscreening for Amblyogenic Fctors in Infants & Young Children
- Su Mi Ihn, Sang Hyun Byun, Hang Jin Cho, Byung Mu Min
- Clin Exp Pediatr. 2000;43(10):1380-1385. Published online October 15, 2000
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Purpose : Amblyopia is the commonest cause of defective vision in childhood. It develops during the sensitive period of visual maturation which continues until about 7-8 years of age. The authors investigated the effect of a polaroid photoscreening camera designed to detect amblyogenic factors, including asymmetric and abnormal refractive errors, strabismus, ptosis and media opacities. Methods : Fifty-four children aged... -
- Organic Acid Analysis on Urine Samples Obtaine3d from Dried Filter Paper in Newborns : Development of Screening Method for Organic Aciduria in Newborns
- Eun Ha Lee, Si Houn Hahn
- Clin Exp Pediatr. 2000;43(10):1311-1317. Published online October 15, 2000
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Purpose : Neonatal screening for inherited metabolic disease is aimed at identifying affected infants early, thus permitting medical intervention to prevent or minimize the effect of the disease. However, organic aciduria, most of which causes severe disease and mental retardation, is not yet screened routinely because of the difficulty of tests, sample collection, and expenditure of time and financial resources.... -
- Diagnostic Significance of the Urine-Stick Test in Middle and High School Children in Seoul
- Mi Jung Park, Yun Ju Kang, Jong Hee Kim, Duk Hi Kim
- Clin Exp Pediatr. 2000;43(3):411-416. Published online March 15, 2000
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Purpose : This study was performed to assess the diagnostic significance of the urine-stick test in detecting Diabetes Mellitus(DM) and to assess the clinical characteristics of adolescent diabetes. Methods : A total of 926,208 middle and high school children participated. The urine-stick test was performed and those who showed glycosuria and, further studies such as evaluations of plasma glucose, triglyceride, cholesterol... -
- The Seoul Infant Developmental Screening Test
- Keun Lee
- Clin Exp Pediatr. 2000;43(3):335-343. Published online March 15, 2000
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Purpose : The importance of early detection of developmental delays during infancy and preschool years has been repeatedly stressed, as early diagnosis of retardation increases the opportunities for effective therapy. Several screening tests developed in other countries are inappropriate for Korean children. The purpose of this study was to standardize a developmental screening method for Korean children. Methods : One hundred... -
- A Catalogue of Gene Expression Difference in Biliary Cirrhosis due to Biliary Atresia Using Differential Expressed Sequence Tags(EST) Screening
- Byung-Ho Choe, Hyun-Mi Lee, Moon-Kyu Kim, Jung-Chul Kim
- Clin Exp Pediatr. 2000;43(1):60-69. Published online January 15, 2000
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Purpose : Extrahepatic biliary atresia is the most common indication for liver transplantation in children, but the etiology of this disorders remains unknown. It would be very signficant to identify genes that are specifically expressed in pathologic liver tissue of biliary atresia and analyze the pattern of expression in those genes. Methods : We made dot blot panels consisting of 1,730 different EST(expressed sequence... -
- Re-Evaluation of Neonatal Screening Tests for Inborn Errors of Metabolism with Dried Filter Paper Blood Spots
- Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
- Clin Exp Pediatr. 1999;42(12):1639-1644. Published online December 15, 1999
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Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates. Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases... -
- Follow up of Infants with Congenital Hypothyroidism Who were Detected by Newborn Screening Test
- Kyung Ah Kim, Eun Sil Lee, Son Moon Shin, Han Ku Moon, Yong Hoon Park
- Clin Exp Pediatr. 1999;42(8):1141-1148. Published online August 15, 1999
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Purpose : Developmental delay in congenital hypothyroidism can be prevented by early detection and treatment. We conducted a follow-up study to assess the growth and development of infants with congenital hypothyroidism who were detected by newborn screening test and received thyroid hormone therapy. Methods : Nineteen hypothyroid infants were detected by newborn screening test from April 1995 to May 1997. Measurements... -
- Screening Device for Developmental Delay at Well Baby Visit
- Keun Lee
- Clin Exp Pediatr. 1999;42(8):1043-1049. Published online August 15, 1999
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Purpose : Developmental delay is a fairly common problem in childhood and its early diagnosis is crucial not only for the child but also for the family and society. If found early and properly managed, the side effects can be minimized and the child with developmental delay will have a better prognosis. However, early diagnosis is difficult due to various... -
- Analysis of Urinary Mass Screening for Elemantary, Junior and High School Children Over a 8-year Period in Seoul
- Chong Guk Lee, Dong Whan Lee, Sae Won Yang, Sung Ho Cha, Chang Ho Hong, Yong Mook Choi, Hyun Soon Lee, Sung Jae Seo
- Clin Exp Pediatr. 1997;40(10):1347-1359. Published online October 15, 1997
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Purpose : The urinary mass screening program for the detection of proteinuria had been performed for a school age population in the city of Seoul since 1981. However, systematic evaluation for this program had never been done. We, therefore, designed a systematic evaluation in corporation with the Seoul School Health Center for students with proteinuria identified in the mass screening to determine the prevalence... -
- Diagnosis of Cytomegalovirus Infection in Neonatal and Infantile Periods Using Polymerase Chain Reaction
- Young Ah Lee, Kyoung Lee, In Seong Jo, Woo Gap Chung
- Clin Exp Pediatr. 1996;39(9):1271-1279. Published online September 15, 1996
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Purpose : The aims of present study were to document the incidence of cytomegalovirus infection in neonatal and infantile periods especially in high-risk patients of associated infection by nested PCR of DNA from leukocytes and to evaluate the effectiveness of nested PCR in the diagnosis of congenital cytomegalovirus infection. Methods : Genomic DNA was extracted from peripheral leukocytes of 204 neonates and infants during the... -
- The Influence of the Use of Iodine during Perinatal Period on the Screening Test for Congenital Hypothyroidism
- Gyu Bum Cho, Dong Hwan Lee, Sang Jhoo Lee
- Clin Exp Pediatr. 1996;39(2):195-206. Published online February 15, 1996
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Purpose : This study was performed to detect the diseases of congenital hypothyroidism by the neonatal mass screening test early and to demonstrate the possible role of topical iodinated antiseptics(povidone-iodine, PVP-Ⅰ) on transient hyperthyrotropinemia in newborn infants. Methods : We performed neonatal screening tests for inborn errors of metabolism since 1985 by Guthrie test for PKU, maple syrup urine disease, histidinemia,... -
- Iron Deficiency Anemia in Infants
- Woon Ja Chung, Kue Sook Kim, Mi Kyung Kim, Shin Na Kim
- Clin Exp Pediatr. 1995;38(9):1253-1261. Published online September 15, 1995
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Purpose : To study the incidence of iron deficiency anemia we conducted blood tests with questionnaire regrarding weaning status. We tried to figure out the relation between iron deficiency anemia and financial and educational levels of their parents. The purpose of this study is to emphasize the importance of screening for iron deficiency anemia at well baby clinic and educate mothers... -
- Auditory Brainstem Responses in Premature and Fullterm Infants
- Hyun Mi Kim, Tae Sung Ko, Ki Soo Kim, Moo Song Lee, Kyung Hee Kim
- Clin Exp Pediatr. 1995;38(8):1036-1045. Published online August 15, 1995
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Purpose : We tried to know normal range of auditory brainstem responses in premature and fullterm infants who have no rksk factor during perinatal period and to determine that the abnormal ABR in premature and fullterm infants may predict developmental delay. Methods : ABR evaluations were performed on 283 premature and fullterm infants from NICU of the Asan Medical Center during... -
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- Case Report
- Two Cases of Congenital TBG Deficiency
- In Seong Jo, Ha Joo Choi, Young Ah Lee, Woo Gap Chung, Youn Bok Chang
- Clin Exp Pediatr. 1995;38(5):697-701. Published online May 15, 1995
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We have experienced 4 and 5-week-old male neonates presented low T4 and normal TSH l-evel by filter paper mothod for neonatal screening, finally diagnosed typical TDG deficiency wit h TBG radioimmunoassay, paper electrophoresis, and autoradiography. Two neonates have ha d no specific complaints and lived well until now. Congenital TBG deficiency is an X chromosome linked inhcritant disorder characterized by l... -
- Original Article
- Etiological Classification of Mentally Retarded Children Enrolled in a Special Educational Institution
- Seon-Kyeong Yoo, Han-Wook Yoo
- Clin Exp Pediatr. 1994;37(10):1437-1448. Published online October 15, 1994
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Mental retardation(MR) is classically deficits in adaptive behavior and manifest during the developmental period. The causes of mental retardation were not understood in many cases. This study was undertaken to identify the etiologies of mentally retarded children enrolled in a special educational institution under the hypothesis that clarifying causes of MR can not only provide basic epidemiological data on MR in... -
- Normal Blood TSH, T4 Levels in Neonates as Determined by Screening Test
- In Ah Cha, Kwang Sin Kim, Kyoung Sim Kim, Young Wook Kim, Ki Bok Kim
- Clin Exp Pediatr. 1994;37(6):832-841. Published online June 15, 1994
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In 1,146 term neonates without perinatal problems who were born in kwangju Christian Hospital, blood TSH levels were measured by immunoradiometric assay. In 397 term neonates among them, blood T4 levels were measured by radioimmunoassay in same specimens. 1) In normal neonates aged 3~5days, 6~10days, 11~20days and 21~28days, the TSH levels were 8.885.21(meanSD), 9.44¡¾5.16, 9.69¡¾4.98, 11.963.75IU/ml and the T4 levels were... -
- A Study of Screening for Anemia in 9 Month Old Infants in Well Baby Clinic
- Yong Sik Min, Jae Ock Park, Sang Man Shin, Sang Jhoo Lee
- Clin Exp Pediatr. 1993;36(11):1516-1525. Published online November 15, 1993
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Iron deficiency remains the most common cause of anemia in infants and children despite increasing availability of iron-fortified foods. We screened out anemia in 9-month old infants in well baby clinic to know the prevalence of anemia and the weaning status. The results were as follows. 1) Among 345 infants screened, 24 infants(7%) were found to have anemia. 2) The king of anemia... -
- Re-evaluation of TSH Screening TEST in Neonates
- Jin Young Song, Dong Woo Son, Beyong Il Kim, Sei Won Yang, Jung-Hwan Choi, Chong Ku Yoon, Hyung Ro Moon
- Clin Exp Pediatr. 1993;36(11):1502-1506. Published online November 15, 1993
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Five years ago, we made the cut-off value of TSH by dry filter paper method as 15μU/ml to screening congenital hypothyrodism. Since then, 1,210 term neonates, who had no perinatal problems, screening test with this cut-off point. Neonates had been recalled for measurement of serum T4/TSH to rule out congenital hypothyroidism if their TSH value by screening tests reveal more... -
- Seventeen Years Experience on Inborn Errors of Metabolism A Study for Future Development of Inborn Errors of Metabolism in Korea.
- Hong Jin Lee, Hyung Ro Moon
- Clin Exp Pediatr. 1990;33(8):1031-1036. Published online August 31, 1990
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In Korea, the study of inborn errors of metabolism is very primitive. Even the incidence and prevalence of the disease of inborn errors of metabolism are not known in Korea. We have done this study of inborn errors of metabolism in Korea and concluded that: 1) The varieties and incidences of inborn errors of metabolism in Korea might be relatively diverse and high. 2) Nation wide mandatory... -
- Analysis of Asymptomatic Proteinuria in School Children.
- Chong Guk Lee, Tae Sub Shim, Dong Hwan Lee, Yong Soo Yun, Chang Jun Ko, Sa Jun Chung, Hyun Soon Lee, Sung Jae Suh, Pyung Nam Kim
- Clin Exp Pediatr. 1989;32(9):1187-1194. Published online September 30, 1989
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Uriary mass screening program for the detection of proteinuria had been performed for a school- age population in the city of Seoul since 1981. Annually, about half million students, who comprised 3 different age group, corresponding to the averages of 11，14, and 17 years, had been examined. A systematic clinical evaluation was designed for students with proteinuria identified in the mass screening through ’87... -
- Studies on Arrhythmias in School Children.
- Young Hwue Kim, Hann Tchah, Ki Soo Kim, Chung Il Noh, Jung Yun Choi, Young Soo Yun, Chang Yee Hong
- Clin Exp Pediatr. 1989;32(8):1093-1097. Published online August 31, 1989
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To determine the incidence of cardiac arrhythmias of the school children, we have performed heart screening by the questionare and EKG and physical examination from September 1984 to October 1987 in Seoul. 1) The incidence of the cardiac arrhythmias was 1.27%. 2) There were 449 cases of heart diseases detected. Among these heart diseases there were congeni- tal heart diseases in 82 cases (0.31%), acquired heart diseases... -
- Psychosocial Screening of Childhood Asthmatic Parient by PSC(Pediatric Symptom Checklist).
- Hye Hyun Kim, Keun Lee
- Clin Exp Pediatr. 1989;32(5):670-677. Published online May 31, 1989
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It has been accepted that psychosocial difficuties are frequently associated with asthma of childhood, as etiologic factor and/or consequence of the disease. Management of these psychosocial problems has great impact on the course of asthma and early finding of the problems has been strongly advocated. The purpose of this study was to evaluate psychosocial functioning of asthmatic patients and compare them with other groups... -
- Normal TSH Levels in Neonates by TSH Screening test.
- Jae Won Song, Jong Lin Rhi, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Hyung Ro Moon, Bo Youn Cho, Chang Soon Koh
- Clin Exp Pediatr. 1988;31(6):754-761. Published online June 30, 1988
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In 110 term neonates without perinatal problems who were bom in SNUH, blood TSH levels were measured by TSH screening test for congenital hypothyroidism. The results are as follows 1) Normal TSH level was 14.8±7.8 µU/ml, 8.8±4.7 µU/ml, and 6.5±2.7 µU/ml in neonates of age 0 〜24 hours, 24—48 hours, and 48〜72 hours respectively, and all TSH values in neonates of age 48〜72 hours were... -
- Standardization of the Denver Developmental Screening Test on Seoul Children.
- Kun Lee
- Clin Exp Pediatr. 1987;30(9):958-971. Published online September 30, 1987
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Total 2140 Seoul children, aged from 2 weeks to 6 years 4 months were evaluated with Denver Developmental Screening Test and the results were compared with those of Denver and Tokyo children. Seoul children were found to be advanced in all 4 sectors of DDST, e.g. personal, social, fine motor, adaptvie, language and gross motor than Denver or Tokyo counterparts. Korean youngsters fast development... -
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