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Normal Blood TSH, T4 Levels in Neonates as Determined by Screening Test

Journal of the Korean Pediatric Society 1994;37(6):832-841.
Published online June 15, 1994.
Normal Blood TSH, T4 Levels in Neonates as Determined by Screening Test
In Ah Cha, Kwang Sin Kim, Kyoung Sim Kim, Young Wook Kim, Ki Bok Kim
Department of Pediatrics, Kwangju Christian Hospital, Kwangju, Korea
신생아 혈중 TSH, T4 의 선별검사 정상치
차인아, 김광신, 김경심, 김용욱, 김기복
광주기독병원 소아과
In 1,146 term neonates without perinatal problems who were born in kwangju Christian Hospital, blood TSH levels were measured by immunoradiometric assay. In 397 term neonates among them, blood T4 levels were measured by radioimmunoassay in same specimens. 1) In normal neonates aged 3~5days, 6~10days, 11~20days and 21~28days, the TSH levels were 8.885.21(meanSD), 9.44¡¾5.16, 9.69¡¾4.98, 11.963.75IU/ml and the T4 levels were 11.41¡¾2.79, 11.37¡¾2.82, 11.19¡¾2.63, 10.51¡¾2.99g/dl, respectively. 2) No significant sex difference in TSH level was found in each age group, and TSH level did not correlate with birth weight, In neonates delivered by Cesarean section, TSH levels were lower than those of the normally delivered 3) T4 levels did not differ between both sexes, and between types of delivery ineach age group, and nor did it correlate with birth weight. 4) If the recall rate should be set at 0.2% of the total, TSH levels above 26.9IU/ml would be required to recall for serum sampling. TSH level above 2SD was 19.7IU/ml. Cutoff points of T4 levels at 1.5SD and 2SD were 5.8 and 7.2g/dl respetively, and the lowest 10th percentile was 7.4g/dl.
Key Words: TSH, T4, Neonatal screening

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