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Original Article
Subclinical left ventricular dysfunction in children after hematopoietic stem cell transplantation for severe aplastic anemia: a case control study using speckle tracking echocardiography
Beom Joon Kim, Kyung Pil Moon, Ji-Hong Yoon, Eun-Jung Lee, Jae Young Lee, Seong Koo Kim, Jae Wook Lee, Nack Gyun Chung, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2016;59(4):190-195.   Published online April 30, 2016

Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated with multiple transfusions and HSCTrelated complications may adversely affect cardiac function. Left ventricular (LV) function was assessed in children after HSCT for SAA.


Forty-six consecutive patients with a median age of 9.8...

Case Report
Use of intravenous immunoglobulin in a disseminated varicella infection in an immunocompromised child
Jae Hong Kim, Dae Hyun Kwon, E Young Bae, Seung Beom Han, Jae Wook Lee, Nack Gyun Chung, Dae Chul Jeong, Bin Cho, Jin Han Kang, Hack Ki Kim
Clin Exp Pediatr. 2014;57(8):370-373.   Published online August 25, 2014

Varicella-zoster virus infection can lead to severe illness in immunocompromised patients. Further the mortality rate of disseminated varicella infection is extremely high particularly in immunocompromised children. We report a case of disseminated varicella infection in a child with acute lymphoblastic leukemia who was receiving chemotherapy, but was initially admitted with only for acute abdominal pain. The patient rapidly developed severe...

Original Article
Distribution of CD4+CD25+ T cells and graft-versus-host disease in human hematopoietic stem cell transplantation
Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2008;51(12):1336-1341.   Published online December 15, 2008
Purpose : This study aimed to determine the frequencies of CD4+CD25+ T cells in donor graft and peripheral blood CD4+CD25+ T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD). Methods : Seventeen children who underwent HSCT were investigated. CD4+CD25+ T cells in samples from donor grafts and recipient peripheral blood were assessed...
Clinical outcomes of hematopoietic stem cell transplantation from HLA-matched parental donor in childhood acute leukemia
Eun Young Cha, Moon Hee Lee, Jae Wook Lee, Young Joo Kwon, Dae Hyoung Lee, Young-Shil Park, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2008;51(1):67-72.   Published online January 15, 2008
Purpose : In this study, we retrospectively analyzed the clinical outcomes of patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) grafted from HLA-matched parents. Methods : Seven children with acute leukemia (4 acute lymphoblastic leukemia, 3 acute myeloid leukemia) in first complete remission received allogeneic HSCT from their respective parents at the St. Marys Hospital between April, 1999 and October,...
The effects of shortened dexamethasone administration on remission rate and potential complications during remission induction treatment for pediatric acute lymphoblastic leukemia
Jae Wook Lee, Kwang Hee Lee, Young Joo Kwon, Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2007;50(12):1217-1224.   Published online December 15, 2007
Purpose : Due to its high potency against leukemic blasts, our institution has opted for the use of dexamethasone during acute lymphoblastic leukemia (ALL) remission induction, but in our most recent treatment protocol, CMCPL-2005, we shortened the length of steroid treatment from 4 to 3 weeks. We compared both the rates of remission induction and significant complications observed during induction...
Review Article
Aplastic anemia
Hack Ki Kim
Clin Exp Pediatr. 2007;50(6):519-523.   Published online June 15, 2007
Aplastic anemia is a rare disease, which is characterized by pancytopenia and hypocellular bone marrow without infiltration of abnormal cells or fibrosis. The incidence in Asia is higher than in the West and new cases are diagnosed at a rate of 5.1 per million pediatric populations per year in Korea. The pathophysiology is understood roughly by defective hematopoiesis, impaired bone...
Original Article
Short-term Results of Hematopoietic Stem Cell Transplantation for Children with Myelodysplastic Syndrome
Jin Lee, Soh Yeon Kim, Bin Cho, Pil Sang Jang, Nak Gyun Chung, Hack Ki Kim
Clin Exp Pediatr. 2002;45(3):370-375.   Published online March 15, 2002
Purpose : In most cases, myelodysplastic syndrome(MDS) transforms into a more aggressive state or acute myelogenous leukemia; it's prognosis is very poor. It is believed that hematopoietic stem cell transplantation(HSCT) is the only curative treatment of MDS, but available data in children are very sparse. In this report, the short term outcome of HSCT in childhood MDS was analyzed. Methods :...
One Hundred Cases of HLA-matched Sibling Allogeneic bone Marrow Transplantation in Children : Single Center Study
Hack Ki Kim, Bin Cho, Nak Gyun Chung, Dae Chul Jeong, Soh Yeon Kim, Hyun Jung Lee, Kyong Su Lee, Kyung Ja Han, Won Il Kim, Il Bong Choi, Chun Choo Kim
Clin Exp Pediatr. 2000;43(3):402-410.   Published online March 15, 2000
Purpose : We reviewed 100 cases of HLA-matched sibling allogeneic bone marrow transplantation( allo-BMT) in children and wish to share these results. Methods : One hundred children had undergone allo-BMT from HLA-identical siblings between Nov. 1983 and May 1998. There were 50 males and 50 females with a median age of 10 years and a median follow-up of 38 months. Out of 100 cases,...
Clinical Lecture
Diagnosis and Treatment of Childhood Hemorrhagic Disorders
Hack Ki Kim
Clin Exp Pediatr. 1996;39(7):901-907.   Published online July 15, 1996
Original Article
Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1067-1072.   Published online August 15, 1993
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence...
Treatment of Aplastic Anemia
Nak Gyun Chung, Kyu Jin Bhang, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1059-1066.   Published online August 15, 1993
We performed this study to evaluate the therapeutic responses of bone marrow transplantation and immunosuppressive therapy for aplastic anemia in 103 cases(68 severe and 35 moderate). Among them, 15 cases with severe aplastic anemia having HLA-identical sibling donor underwent bone marrow transplantation, and cases (53 severe and 35 moderate cases) without available HLA-identical sibling donor had received immunosuppressive therapy using...
Treatment of severe aplastic anemia: comparison between bone marrow transplantation and immunomodulation.
Dae Chul Jeong, Sung Dong Choi, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):172-179.   Published online February 28, 1991
Twenty, six children younger than 15 years with severe aplastic anemia underwent either bone marrow transplantation or immunomodulation therapy (antilymphocyte globulin with cyclosporin A therapy). Six patients who had an HLA-identical sibling donor underwent bone marrow transplantation after conditioning with cyclophosphamide, procarbazine and antilymphocyte globulin. Twenty children who did not have an HLA-identical donor recieved antilymphocyte globulin and cyclosporin A. The results were as follows; 1) Hematologic responses:...
Molecular analysis of childhood acute lekemia.
Hack Ki Kim, Kyong Su Lee, Sung Hoon Cho, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):164-171.   Published online February 28, 1991
Immunoglobulin (Ig) and T cell receptor 0 chain (TcR分) gene rearrangements can be used as ”genetic marker” of lineage and clonality in the study of lymphoproliferative disease. We analyzed genomic DNA of the bone marrow mononuclear cells from twenty six patients with acute leukemia in children. The patients were seventeen cases of acute lymphocytic leukmia (ALL), seven cases of acute nonlymphocytic leukemia (ANL) and...
Two cases of hybrid leukemia.
Sung Dong Choi, Dae Chul Jung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee
Clin Exp Pediatr. 1991;34(1):130-136.   Published online January 31, 1991
The hybrid acute leukemia is defined as acute leukemia with both myeloid and lymphoid features. We experienced and report two cases of hybrid leukemia which were identified by morpholgy, cytochemical stain, reactivity with monoclonal antibody, analysis of immunoglobulin and T cell receptor genes rearrangement in 14 years old boy and 10 years old girl.
Immunomodulation Therapy in Children with Aplastic Anemia.
Won Suk Suh, Ki Sik Min, Woo Gun Choi, Hack Ki Kim, Kyoung Sn Lee, Soon Yong Lee
Clin Exp Pediatr. 1990;33(2):170-177.   Published online February 28, 1990
Thirty patients with aplastic anemia(fifteen severe aplastic anemia and fifteen moderate aplastic anemia) treated with antilymphocyte globulin and cyclosporin A as a kind of immunomodulation therapy were studied by analysing hematologic reseponses and complications. The results were as follows; 1) Nineteen out of thirty patients (63.3%) treated with anti lymphocyte globulin plus cyclosporin A showed responses (complete response of 33.3%, partial response of 30.0%). 2) Hematologic responses according...
Statistical Observations for Pediatric Inpatients.
Byung Cheol Han, Hack Ki Kim, Byung Churl Lee, Kyong Su Lee, Sung Hoon Cho, Du Bong Lee
Clin Exp Pediatr. 1987;30(4):385-392.   Published online April 30, 1987
We observed the patients admitted to the department of pediatrics of St. Mary*s Hospital, Catholic Medical College during the past 20 years from Jan. 1966 to Dec. 1985 and classified them by year and disease according to the International Classification of Disease by W.H.O. (1965 Revision). The results were as follows: 1) The total number of pediatric inpatients during 20 years was 18,686, of which...
Case Report
A Case of Chondroma in the Mediastinum.
Hyun Mee Lee, Jin Oh Lee, Hack Ki Kim, Byung Churl Lee
Clin Exp Pediatr. 1986;29(10):1143-1146.   Published online October 31, 1986
Most chondroma often occur within or on the surface of the tubular bone and soft tissue, and are also found in many organs, but it is extremely rare in the mediastinum. Recently, we experienced a case of chondroma of the middle mediastinum, in a 13-years old girl with intermittent chest discomfort and exertional dyspnea for several months. Diagnosis was made by...
A Case of Patent Urachus.
Jong Wan Kim, Hack Ki Kim, Chung Sik Chun, Chang Kyu Oh, Mahn Kyoo Yang
Clin Exp Pediatr. 1982;25(3):295-299.   Published online March 31, 1982
Pateat urachus is a uncommon disease and it has a good prognosis if there is no combired major anomaly and evidence of malignancy. This paper presents one case of patent urachus which was found and removed surgically during the neonatal period. A brief review of related literatures is also presented.
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