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Case Report
Autosomal dominant hypocalcemia with Bartter syndrome due to a novel activating mutation of calcium sensing receptor, Y829C
Keun Hee Choi, Choong Ho Shin, Sei Won Yang, Hae Il Cheong
Clin Exp Pediatr. 2015;58(4):148-153.   Published online April 22, 2015

The calcium sensing receptor (CaSR) plays an important role in calcium homeostasis. Activating mutations of CaSR cause autosomal dominant hypocalcemia by affecting parathyroid hormone secretion in parathyroid gland and calcium resorption in kidney. They can also cause a type 5 Bartter syndrome by inhibiting the apical potassium channel in the thick ascending limb of the loop of Henle in the...

Review Article
Calcium and phosphate metabolism and disorders in the newborn
Hae Soon Kim
Clin Exp Pediatr. 2007;50(3):230-235.   Published online March 15, 2007
In the early neonatal period, the neonate is challenged by the loss of the placental calcium transport and manifests a quick transition, from an environment in which PTHrP plays an important role to a PTH- and 1,25-dihydroxyvitamin D-controlled neonatal milieu. Disturbances in mineral homeostasis are common in the neonatal period, especially in premature infants and infants who are hospitalized in...
Case Report
A Case of CATCH22 Syndrome with First Attack of Hypocalcemic Seizure at 13 Years of Age
Young Won An, Mi Jin Jung, Jee Suk Yu, Young Seok Lee, Han Wook Yoo
Clin Exp Pediatr. 2004;47(7):794-798.   Published online July 15, 2004
The acronym 'CATCH22' is characterized by many clinical manifestations such as cardiac defects, abnormal face, thymic and parathyroid hypoplasia, cleft palate and hypocalcaemia. It is now known to arise from chromosome 22q11.2 microdeletion, and it is also called 22q11.2 deletion syndrome. Hypocalcemia occurs in more than 50% cases of this syndrome, most frequently in neonatal periods, with some exceptions. Our...
A Case of DiGeorge Syndrome
Young Joo Son, Yu Sik Jeon, Soon Lee Jung, Kyuchul Choeh
Clin Exp Pediatr. 1998;41(3):390-395.   Published online March 15, 1998
We experienced a case of DiGeorge syndrome in a 25-day-old male infant presented with micrognathia, short neck, fish-shaped mouth and intractable seizures with a loading dose of phenobarbital & dilantin. The serum calcium level was 3.7mg/dl, ionized calcium level was 0.62mmol/L, and parathyroid hormone carboxy-terminal level was 0.01ng/ml. We treated with it calcium gluconate infusion, low phosphorous formula milk feeding, and...
Original Article
Clinical Observations of Transient Idiopathic Hypocalcemia
Jeong Nyun Kim, Mi Jung Park, Duk Hi Kim, Ho Sung Kim
Clin Exp Pediatr. 1995;38(9):1193-1200.   Published online September 15, 1995
Purpose : In concern of diagnosis and treatment of transient idiopathic hypocalcemia, a major cause of infantile, we studied the onset of age, clinical characteristics, laboratory findings, and duration of treatment and recovery of transient idiopathic hypocalcemia. Methods : The author observed 19 infants with transient idiopathic hypocalcemia who had been admitted to Yonsei university hospital due to convulsion for 4...
Childhood Infection-associated Hypocalcemia
Mi Reong Kim, Seoung Hwan Kim, Hee-Shang Youn, Chong-Hwa Kim
Clin Exp Pediatr. 1993;36(2):223-231.   Published online February 15, 1993
The causes of hypocalcemia in patients suffering from severe infection including sepsis are largely uncertain. So we measured serum albumin, total protein, cholesterol, PTH, and calcitonin of the infection-associated hypocalcemic chlidren and compared with those of normocalcemic children department of pediatrics of Gyeongsang National University Hospital. Hypocalcemic patients were compared to the decreased amount of serum albumin in the hypocalcemic...
Neonatal hypocalcemia: clinical manifestations and prognosis.
Jeong Lim Kim, Heung Dong Kim, Chang Jun Coe
Clin Exp Pediatr. 1991;34(7):912-920.   Published online July 31, 1991
Hypocalcemia during the newborn period is relatively common particularly in infants with predis- posing factors, such as prematurity, low birth weight, birth asphyxia and diabetic mothers and it is often manifested by various clinical findings. Some authors have reported that in some cases of the neonatal hypocalcemia, there were neurologic deficits such as irritability and convulsion, and neur- ologic sequelae on follow up. It...
A Case of DiGeorge's Syndrome.
Jong Sik Kim, Dae Young Kim, Kang Ho Kim, Choon Ho Park, Young Bong Park, Kwang Rhun Koo, Chang Soo Ra
Clin Exp Pediatr. 1988;31(1):100-105.   Published online January 31, 1988
DiGeorge’s syndrome is characterized by partial or complete absence of the parathyroid gland and thymus gland and often associated with the cardiovascular and craniofacial anomalies. A-22-days old male infant, delivered without complications at term after a normal pregnancy, developed irritability, feeding difficulties, dyspnea and convulsion. He was characterized by a low-set, malformed right ear, short philtrum of the upper lip, absence of the thymic...
A Study on Calcium Metabolism in Newborn Infants.
Jin Heon Kim, Chang Soo Ra
Clin Exp Pediatr. 1985;28(10):967-976.   Published online October 31, 1985
A thorough understanding of calcium homeostasis and metabolism in newborn infants is necessary in the evaluation of any newborn infant with hypocalcemia. Author studied the levels of urinary calcium and phosphorus during the 48 hours after birth, and also studied before and after feeding during the 24 hours after birth in 19 normal term infants. And serum calcium, phosphorus, parathormone,...
Case Report
Acute Tumor Lysis Syndrome.
Sun Oak Park, In Sil Lee, Hyp Seop Ahn, Yong Choi
Clin Exp Pediatr. 1984;27(3):303-312.   Published online March 31, 1984
To assess the incidence and the effectiveness of preventive measures for tumor lysis syndrome, we analyzed the serial electrolytes levels in leukemia (Group A, 15 patients) and in lymphoma (Group B, 8 patients) patients. The results were 1)Serum LDH were elevated in all of the patients before the chemotherapy. 2)Serum uric acid were also elevated in 8 patients (A 5, B...
Original Article
Clinical Observation for Hypocalcemia in Infant.
Seon Myeong Kim, Sang Woo Kim, Du Hee Kim
Clin Exp Pediatr. 1983;26(12):1196-1202.   Published online December 31, 1983
Clinical observations were made on 34 cases of hypocalcemia in infancy treated at Depart' ment of Pediatrics of Inje Medical College Seoul Paik Hospital during the period of January 1975-December 1982. The results obtained are as follows: 1) Male to female ratio of the patients was 3.1 ： 1. 2) About 67.7% of hypocalcemic patients were under 28 days old. 3) Serum calcium levels of all the cases were...
Clinical Study of Hypocalcemia in Childhood.
J Choi, K Y Yoon, G J Choi, Y C Song, C M Park
Clin Exp Pediatr. 1981;24(12):1157-1164.   Published online December 15, 1981
This is the study of clinical observation on 60 casesof Hypocalcemia, which were admitted to the Pediatric department of Hanyang University College of Medicine during the period of-May 1972 through August 1980. The following results were obtained. 1)The sex incidence revealed slightly male predominance with male to female ratio al out-1.72:1. 2)The age incidence was peaked in the group of age...
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