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Original Article
The effect of rhinovirus on airway inflammation in a murine asthma model
Eugene Kim, Huisu Lee, Hyun Sook Kim, Sulmui Won, Eu Kyoung Lee, Hwan Soo Kim, Kyongwon Bang, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 2013;56(11):482-489.   Published online November 27, 2013

The aim of the present study was to investigate the differences in lower airway inflammatory immune responses, including cellular responses and responses in terms of inflammatory mediators in bronchoalveolar lavage fluid (BALF) and the airway, to rhinovirus (RV) infection on asthma exacerbation by comparing a control and a murine asthma model, with or without RV infection.


BALB/c mice were intraperitoneally injected...

Epidemiology of Kawasaki disease in infants 3 months of age and younger
Eun Jung Lee, Yong Won Park, Young Mi Hong, Joon Sung Lee, Ji Whan Han
Clin Exp Pediatr. 2012;55(6):202-205.   Published online June 21, 2012

This study investigated the epidemiology of Kawasaki disease (KD) in infants ≤3-month-old.


To study the epidemiology of KD in Korea, data for 27,851 KD patients were collected on a 3-year basis between 2000 and 2008 in a retrospective survey. From this, data for 609 KD patients ≤3-month-old were analyzed and compared with the data for KD patients >3-month-old.


The 609 KD patients...

Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma
Yanghua Ju, Seung Jun Choi, Huisu Lee, Hyun Sook Kim, Sulmui Won, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Joon Sung Lee
Clin Exp Pediatr. 2011;54(11):456-462.   Published online November 30, 2011

Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question.


We prepared Dermatophagoides...

Epidemiologic study of Kawasaki disease in 6 months old and younger infants
Yong Won Park, Ji Whan Han, In Sook Park, Chang Hwi Kim, Sung Ho Cha, Jae Sook Ma, Joon Sung Lee, Tae Chan Kwon, Sang Bum Lee, Chul Ho Kim, Heung Jae Lee, Yong Soo Yun
Clin Exp Pediatr. 2008;51(12):1320-1323.   Published online December 15, 2008
Purpose : The aim of this study was to investigate the epidemiologic status of Kawasaki disease (KD) in infants ≤6 months of age. Methods : For the epidemiologic study of KD in Korea, data from 22,674 KD patients were collected from 1997 to 2005 on a 3-year basis by a retrospective survey. From this survey, data of 1,739 KD patients ≤6...
Influence of vascular endothelial growth factor (VEGF) and endostatin on coronary artery lesions in Kawasaki disease
Seon A Kim, Bum Suk Jung, Jong Seo Yoon, Ji Whan Han, Joon Sung Lee
Clin Exp Pediatr. 2007;50(12):1241-1246.   Published online December 15, 2007

Purpose: Recently, there has been several studies to clarify the pathogenesis of Kawasaki disease (KD) and the relations of VEGF and endostatin that act on vascular endothelial cells to the coronary artery complications. In this report, we measured serum levels of VEGF and endostatin in acute and subacute phases of KD to assess the change of these levels and the...
Case Report
A case of acute respiratory distress syndrome treated with surfactant and low dose methylprednisolone
Bo Yeon Choi, Kyong Mo Kim, Jong Seo Yoon, Joon Sung Lee
Clin Exp Pediatr. 2006;49(4):455-459.   Published online April 15, 2006
The major pathogenesis of acute respiratory distress syndrome (ARDS) is an inflammatory process that results from a diversity of injuries to the body. Due to the various cytokines and vasoactive peptides released from the endothelium, the vascular permeability is increased; the migration of inflammatory cells and the leakage of plasma proteins then occur and edema develops in the alveolus. There...
Original Article
Inhibition of Vascular Endothelial Growth Factor-induced Endothelial Cell Differentiation by Intravenous Immunoglobulin and Methylprednisolone
Hyoun Ah Choi, Kyung Hwa Ha, Jong Seo Yoon, Yoon Lee, Joon Sung Lee, Ji Whan Han
Clin Exp Pediatr. 2005;48(8):886-893.   Published online August 15, 2005
Purpose : Kawasaki disease is the most common cause of systemic vasculitis in children less than 5 years of age. Recent immunohistochemistry findings suggest that many vascular growth factors play a role in the formation of the coronary artery lesions. Active remodeling of the coronary artery lesions in Kawasaki disease continues in the form of intimal proliferation and neoangiogenesis for...
The Effects of Intravenous Immunoglobulin(IVIG) and Methylprednisolone on the mRNAs Expressions of VEGF, VCAM-1 and IL-1β of Human Umbilical Vein Endothelial Cells(HUVEC) Stimulated by IL-1β
Soh Yeon Kim, Sun Jeong Lim, Ji Whan Han, Kyung Yil Lee, Joon Sung Lee
Clin Exp Pediatr. 2004;47(12):1325-1333.   Published online December 15, 2004
Purpose : Kawasaki disease(KD) manifests a systemic vasculitis of unknown etiology in young children. Vascular endothelial growth factor(VEGF), vascular cell adhesion molecule-1(VCAM-1) and interleukin-1 beta(IL-1β) may play important roles in the pathogenesis of KD. Intravenous immunoglobulin(IVIG) and methylprednisolone(MP) are therapeutically effective for KD, however, the precise mechanisms of the two drugs are still unknown. We investigated the therapeutic efficacy of...
Serum ECP, RANTES and Eotaxin Levels in Infants with Bronchiolitis
Jong Seo Yoon, Mi Hee Lee, Joon Sung Lee
Clin Exp Pediatr. 2004;47(2):170-176.   Published online February 15, 2004
Purpose : Viral respiratory infection, especially respiratory syncytial(RS) virus, can predispose sufferers to the development of asthma by mechanisms that are presently undetermined. The role of inflammatory mediators in pathogenesis of asthma and RS virus disease is not well-understood. We investigated the performance of serum eosinophil cationic protein(ECP), regulated on activation normal T-cell expressed and secreted(RANTES) and eotaxin levels on...
Case Report
A Case of Hemophagocytic Lymphohistiocytosis in a Child with Systemic Lupus Erythematosus
Ja Young Hwang, Suk Man No, Jin Lee, Pil Sang Jang, Young Hoon Kim, Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 2003;46(10):1029-1031.   Published online October 15, 2003
Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment...
Original Article
The Significances of Chest X-ray Findings and Serum IFN-γ, IL-5, ECP as Predictors of Prognosis of Bronchiolitis and Bronchopneumonia in Infants
Su Hyun Cho, Hyun Seung Lee, Mi Hee Lee, Joon Sung Lee
Clin Exp Pediatr. 2003;46(3):230-235.   Published online March 15, 2003
Purpose : Lower respiratory tract infections in infant and young children are often due to a virus, especially the Respiratory syncytial(RS) virus. Chest X-ray findings in bronchiolitis and bronchopneumonia are different. The radiographic hallmark of bronchiolitis is pulmonary hyperinflation and similar to that of bronchial asthma. Bronchiolitis is predisposed to later development of bronchial asthma. To evaluate the difference of...
The Etiologic Diseases and Diagnostic Usefulness of Color Doppler Ultrasonography in Children with Chronic Coughs
Sun Young Park, Joon Sung Lee
Clin Exp Pediatr. 2002;45(4):489-497.   Published online April 15, 2002
Purpose : The objectives of this study were to investigate the causes of chronic cough and to establish the appropriate diagnostic approach to chronic cough in children. Methods : One hundred and thirty two cases of chronic cough were prospectively evaluated. They visitors to pediatric chronic cough clinics at Kang-nam saint Mary's Hospital of Catholic University from August 2000 to...
Case Report
A Case of Pulmonary Paragonimiasis
Jin Hee Hong, Sung Soo Jin, Nak Gyun Chung, Joon Sung Lee
Clin Exp Pediatr. 1999;42(3):430-436.   Published online March 15, 1999
Paragonimiasis is a parasitic disease found in carnivorous animals which is caused by trematodes of the genus Paragonimus. Human infestation occurs by ingestion of raw or not incompletely cooked freshwater crab or crayfish with the metacercaria. Recently, the prevalence of human paragonimiasis has decreased markedly, however, about one hundred clinical cases have been diagnosed annually by antibody test in Korea....
Original Article
The Significance of Family History, Immunoglobulin E, Total Eosinophils and Eosinophil Cationic Protein as a Predictor of Allergic Diseases
Dong Su Park, Hyun Hee Kim, Joon Sung Lee
Clin Exp Pediatr. 1998;41(9):1273-1282.   Published online September 15, 1998
Purpose : Family history of allergy and cord blood immunoglobulin E concentration have been proven to be predictors of the development of allergic diseases in children. The purpose of this study is to evaluate whether maternal, cord and baby's blood total eosinophils or eosinophil cationic protein(ECP) in addition to the above two predictors could be a predictor of subsequent allergic...
Immunologic Abnormalitiesin Kawasaki Diseaseand the Effect ofIntravenousImmunoglobulin
Joon Sung Lee, Bin Cho, Sung Hoon Cho
Clin Exp Pediatr. 1996;39(5):691-702.   Published online May 15, 1996
Purpose : It has been suggested that immunologic abnormalities play a role in the pathogenesis of vascular injury in Kawasaki disease and the immunologic abnormalities could be regulated by high-dose intravenous immunoglobulin(IVIG). We investigated the peripheral blood lymphocyte subsets, the serum levels of interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) and the effect of high-dose IVIG(400 mg/kg/day for 5 days) on these factors during acute stage of...
Age Related Reference Ranges for Lymphocyte Subsets in Healthy Korean Children
Dong Un Kim, Joon Sung Lee
Clin Exp Pediatr. 1996;39(2):264-272.   Published online February 15, 1996
Purpose : This study was aimed to investigate the age related changes of lymphocyte subset values in healthy Korean children. Methods : Eighty healthy children were divided into four groups: group A(less than 1yr, n=20), group B(from 1 to 211/12 yr, n=20), group C(from 3 to 511/12 yr, n=20), group D(more than 6 yr, n=20). Their blood were examined for the...
Cough Variant Asthma
Bin Cho, Joon Sung Lee
Clin Exp Pediatr. 1995;38(10):1340-1348.   Published online October 15, 1995
Purpose : Asthma, one of the most common of chronic cough in children, is easily diagnosed when classic triad; cough, wheezing, dyspnea are presented. However, it has become apparant that cough may be the sole manifestation of this disease. This cough variant asthma is underdiagnosed and undertreated. The clinical manifestations and subject variables of asthma especially, cough variant asthma had...
Case Report
A Case of Agenesis of the Right Lung Accompanied by Cleft Lip
Dong Joon Lee, Moon Soo Han, Won Bae Lee, Joon Sung Lee
Clin Exp Pediatr. 1995;38(2):252-256.   Published online February 15, 1995
This paper describes a case of agenesis of the right lung in a male neonate, who suffered respiratory difficulty. He was evaluated by plain X-ray, bronchography, lung perfusion scan, chest CT, and brain CT. After he died, autopsy was performed. The results revealed multiple anomalies which included cleft lip and palate, absence of left thumb and radius bone, hemivertebra between L1...
A Case of Congenital Agammaglobulinemia
Sang Yong Kim, Jong Hyun Kim, Jin Han Kang, Joon Sung Lee, Sang In Shim
Clin Exp Pediatr. 1995;38(1):99-103.   Published online January 15, 1995
Congenital agammaglobulinemia was described first among all human immunodeficiencies, and characterized by defect of B lymphocyte maturation and severe panhypogammaglobulinemia. These patients frequently acquire infections with high-grade extracellular pyogenic pyogenic organisms since infancy. We experienced a case of congenital agammaglobulinemia in a 10 years old male. He had history of recurrent pneumonia and purulent otitis media since late infancy. Also he...
A Case of Eosinophilic Gastroenteritis
Moon Young Song, Jong Wan Kim, Joon Sung Lee
Clin Exp Pediatr. 1994;37(10):1457-1462.   Published online October 15, 1994
Eosinophilic gastroenteritis is a rare disorder of unknown etiology characterized by protein losing enteropathy, peripheral eosinophilia and iron deficiency anemia secondary to gastrointestinal blood loss. It is often accompanied by signs of systemic allergy. This case of a 26-month-old male patient who developed scrotal edema and diarrhea for a month had peripheral eosinophilia ranged from 24 to 32% of total leukocyte,...
Original Article
Chronic Cough in Children
Bin Cho, Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1994;37(8):1116-1123.   Published online August 15, 1994
Chromic cough is a symptom frequently encountered by the pediatrician. Although most coughs are self-limited, chronic cough ofter proves to be a frustrating problem. This study was performed at Kangnam St. Mary's Hospital from January 1,1992 to December 31, 1992, and 83 children with chronic cough persisting for longer than 3 weeks was evaluated. We categorized these patients into 5...
Case Report
A Case of Idiopathic Hypereosinophilic Syndrome
Bin Cho, Jin Tack Kim, Joon Sung Lee, Kyoo Hong Cho
Clin Exp Pediatr. 1994;37(7):1020-1027.   Published online July 15, 1994
The idiopathic hypereosinophilic syndrome(HES) represents a heterogenous group of disorder characterized by prolonged eosinophilia of undetectable cause and multiorgan system dysfunction. Bone marrow is the most frequentry involved organ, but the most severe clinicopathologic involvement is heart. The major cause of death in patients with the HES is cardiac dysfunction especially congestive heart failure resulted from endocardial fibrosis and restrictive cardiomyopathy. We...
A Case of Disseminated Tuberculosis woth Tuberculosis Otitis Media
Soo Bong Lee, Jin Tack Kim, Joon Sung Lee, Kyung Su Lee, Whang Lee
Clin Exp Pediatr. 1994;37(1):135-140.   Published online January 15, 1994
Tuberculous otitis media is the second most frequent ENT disease of tuberculous origin. Most cases occur secondarily, when organisms are coughed into the nasopharynx from pulmonary lesions, or as the result of hematogenous spread. The clinical findings are profuse otorrhea, absence of pain, profound hearing loss, perforation of tympanic menbrane and paralysis of facial nerve. We have experienced one case...
Original Article
Eosinophil Cationic Protein in Relation to Bronchial Hyperresponsiveness in Asthmatic Children
Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 1993;36(12):1707-1715.   Published online December 15, 1993
The eosinophil is the major cell responsible for the inflammatory reaction in bronchial asthma. Secretion of granular components is probably of considerable importance for the inflammatory effects of the eosinophils, Eosinophil cationic protein (ECP) is the one of the secretory components of the eosinophil granule and is considered as an activation marker of eosinophil, Blood eosinophil count, serum concentration of...
Case Report
A Case of Vascular Sling
Jong Hyun Kim, Moon Soo Han, Jong Wan Kim, Joon Sung Lee, Hak Hee Kim
Clin Exp Pediatr. 1993;36(7):1034-1038.   Published online July 15, 1993
Pulmonary artery sling is an uncommon and potentially lethal vascular anomaly that can produce airway obstruction. Despite the availibility of a corrective operation, the mortality rate remains very high due to the high incidence of associated obstructive anomalies of the tracheobronchial tree. We experienced a 70-day-old male infant who was admitted to our unit because of sudden dyspnea, cyanosis, coarse...
A Case of Wiskott-Aldrich Syndrome
Dong Un Kim, Seung Hoon Han, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1993;36(3):439-446.   Published online March 15, 1993
Wiskott-Aldrich syndrome s an X-linked combined immunodeficency disorder characterzed by severely decreased number of platelets which are small in size, eczema resembling atopic dermatitis and recurrent infection. The serum of the patient contains elevated concentrations of IgA and IgE, whereas the IgG level is usually normal and IgM level is deecreased. The patient also shows skin test anergy and progressive...
Original Article
A case of hyperimmunoglobulin E syndrome.
Myeong Cheol Shinn, Sung Dong Choi, Byung Gyu Suh, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1991;34(2):292-298.   Published online February 28, 1991
The hyperimmunoglobulin E syndrome is a primary immunodeficiency disorder characterized by serious recurrent bacterial infections of the skin and respiratory system in early life, and markedly elevated serum IgE level. These recurrent infections are generally subcutaneous abscesses caused by Staphylococcus aureus. Also, additional characteristrics of this syndrome include coarse facial appearance, chronic pruritic dermatitis and eosinophilia. The baisic immunologic defect mechanism in hyperimmunoglobulin E syndrome is...
Immunologic Changes in Bronchial Asthma on Immunotherapy.
Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1990;33(9):1255-1261.   Published online September 30, 1990
The best treatment of allergic disease is to avoid exposure to known allergen. Immunotherapy has been attempted in IgE-mediated allergic patients who didn’t show any responses to pharmacologic therapy or couldn’t avoid allergen. There have been many enthusiastic claims for symptomatic relief of allergic disease by various forms of hyposensitization, first introduced by Noon and Freeman (1911) in the treatment of hay fever. The mechanism of...
A Case of Cold Urticaria.
Chul Ho Lee, Sung Ik Chang, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1990;33(7):1012-1017.   Published online July 31, 1990
Cold urticaria is one of the most common forms of physical urticaria characterized by pruritus, hive formation, redness, swelling, angioedema and occasionally symptoms of hypotension after cold exposure. Usually the diagnosis can be ascertained with the use of an ice cube test or an ice water immersion test, in which a wheal reaction appears oh the exposed skin in 10 〜 20 minutes....
Case Report
Two Cases of Right Congenital Diaphragmatic Anomaly.
Hyun Kyung Cho, Joon Sung Lee, Jung Il Kim, Mahn Kyoo Yang, Ku Kim, Seung Nam Kim, Jae Sung Kim
Clin Exp Pediatr. 1979;22(7):550-555.   Published online July 15, 1979
Congenital diaphragmatic anomaly is a rare congenital malformation and is found more frequently on the left side than right side. We had experienced two cases of comgenital diaphragmatic anomaly on the right side. One case was 8 months old male with congenital Bochdalek hernia and the other case was 17 months old female with congenital eventration of the diaphagm. The...
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