Journal of the Korean Pediatric Society 1987;30(11):1221-1227.
Published online November 30, 1987.
Immunogenecity of Low-Dose Administration of Hepatitis B Virus Vaccine in School Aged Group.
Young Mo Sohn1, Pyung Kin Kim1, Kyung Soon Song2
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea
학동기 연령층에서 B형 간염 백신 감량 접종후의 면역효과에 대한 연구
손영모1, 김병길1, 송경순2
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 임상병리학교실
Abstract
For evaluation of immunogenecity of low-dose of hepatitis vaccine-prepared by Korea Green Cross Corporation 74 school aged children were given routine schedule (0, 1, 6 months). A dose of 5 microgram was administered intramuscullary in the cases of age under 10 yrs of age and 10 microgram was administered in the cases over 11 yrs of age. An adequate follow-up observation of antibody titer by RIA was possible at 1, 2, 6, 7, 12 months after the first injection. In addition, we followed up anti-HBs titer of 45 children whose anti-HBs was positive at the screening survey. The results were as followes: 1) The anti-HBs positive rate was 95.6% (43/45) in the 5 microgram group and 100% (29/29) in 10 microgram group at the time of 12 months after the first injection. The effective rate (seroconversion rate 10 R.U.) was 68.9% (31/45) in the 5 microgram group and 79.3% (23/29) in the 10 microgram group. 2) The geometric mean anti-HBs titer at the 12 months after the first injection was 24.3 R.U. in 5 microgram group and 37.3 R.U. in the 10 microgram group. 3) Seronegative conversion rate of the children who has isolated anti-HBs at screening survey was 23.8% (5/21) at 12 months later. Especially 80% of seroconversion rate was observed in the 5 cases who had anti-HBs titer below 10 R.U. According to the above results, we have evaluated the low-dose administration of hepatitis Bvaccine in school aged children was effective for immunogenecity of this vaccine. But further follow-up of antibody titer must be evaluated and we found that in the most of isolated low titeranti-HBs cases, their antibody disappeared within 12 months.
Key Words: Hepatitis B Vaccine, Immunogencity.




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