| Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine |
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Hyo Geun Ju, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang |
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Department of Pediatrics, College of Medicine, Chonnam University Hospital, Kwangju, Korea |
| 디피티와 동시에 접종한 B형 간염 백신의 효과 |
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주효근, 최영륜, 마재숙, 황태주 |
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전남대학교 의과대학 소아과학교실 |
Correspondence:
Hyo Geun Ju, Email: 1
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| Abstract |
Purpose
: The universal vaccination against hepatitis B during early infancy is the only effective
way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study
was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio
at 2, 4, 6 months of age in babies of HBs antigen negative mothers.
Methods
: One hundred and eighty-one infants who were admitted to the Neonatal Intensive Care
Unit(NICU), Chonnam University Hospital from August, 1994 to December, 1995 were enrolled in
this study. Infants received Hepavax-B 0.5ml(10μg) at contralateral thigh intramuscularly,
simultaneously with DPT vaccination. Antibody was assessed by MEIA(microparticle enzyme
immunoassay) at seven to nine months of age.
Results
: The seroconversion rate of Hepatitis B after vaccination was 98.3%. There were no
significant differences in positive rate of antibody according to gestational age, birth weight and
sex. Seroconversion rate to hepatitis B in twins was lower than in singlets. Twenty-two infants
among 23 infants, who were able to assess antibody titer, showed effective antibody titer, above
100mIU/ml.
Conclusion
: The results suggest that the simultaneous administration of hepatitis B vaccine with
DPT/TOPV is very effective and simplifies schedule. Moreover, this schedule will improve the
compliance of vaccination. |
| Key Words:
Simultaneous hepatitis B vaccination, Seroconversion rate |
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