Korean Journal of Pediatrics 2008;51(3):256-261.
Published online March 15, 2008.
The relationship between leptin adiponectin ratio and insulin resistance in healthy children
Gae-Hyun Ahn, Shin-Hye Kim, Eun-Gyong Yoo
Department of Pediatrics, College of Medicine, Pochon CHA University, Seongnam, Korea
건강한 소아에서 렙틴 아디포넥틴 비와 인슐린 저항성의 관계
안계현, 김신혜, 유은경
포천중문의과대학 소아과학교실
Correspondence: 
Eun-Gyong Yoo, Email: pedyoo@cha.ac.kr
Abstract
Purpose
: Leptin and adiponectin are two representative adipocytokines. Leptin increases, but adiponectin decreases, with obesity and insulin resistance. We aimed to study the relationship between the leptin/adiponectin ratio and insulin resistance in healthy children.
Methods
: Seventy-seven healthy children (36 boys and 41 girls) were enrolled in this study. Anthropometric measurements were performed, and the percentage of weight for height (%WFH) was calculated in each subject. Fasting plasma levels of glucose, insulin, leptin, adiponectin, testosterone, estradiol, and sex-hormone binding globulin (SHBG) were measured. The free androgen index (FAI) was used as a representative of testosterone bioactivity. The homeostasis model assessment was used to estimate the degree of insulin resistance (HOMA-IR).
Results
: In the boys, HOMA-IR was significantly correlated with age, pubertal stage, free androgen index (FAI), leptin, and the leptin/adiponectin ratio. HOMA-IR was also significantly related to age, percentage of weight for height (%WFH), pubertal stage, estradiol, leptin, and the leptin/adiponectin ratio in girls. The leptin/adiponectin ratio was independently related to HOMA-IR after adjusting for age, %WFH, and FAI in the boys (P<0.05). The leptin/adiponectin ratio was not independently related to HOMA-IR after adjusting for age, %WFH, and estradiol in girls.
Conclusion
: In non-obese healthy children, the leptin/adiponectin ratio was significantly correlated with insulin resistance. The leptin/adiponectin ratio was independently related to insulin resistance even after adjusting for age, degree of obesity, and androgen levels in healthy boys.
Key Words: Leptin, Adiponectin, Insulin resistance, Children


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