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A Case of Chronic Granulomatous Disease in which Enterococci were Observed in Culture

Journal of the Korean Pediatric Society 2000;43(6):846-850.
Published online June 15, 2000.
A Case of Chronic Granulomatous Disease in which Enterococci were Observed in Culture
Kyunglae Cho, Jeonghee Kim, Eunjeong Kim, Churwoo Yoo, Chunsoo Kim, Unseok Nho, Chulkyu Kim
Department of Pediatrics, College of Medicine, Sung Kyun Kwan University, Masan Samsung Hospital, Masan, Korea
Enterococci가 검출된 만성 육아종성 질환 1례
조경래, 김정희, 김은정, 유철우, 김천수, 노은석, 김철규
마산 삼성병원 소아과
Abstract
Chronic granulomatous disease(CGD) is a genetically inherited disorder caused by the failure of phagocytic cells to produce superoxide. It is characterized by frequent and uncontrollable infection which often lead to death in early childhood. The first clinical signs may be confined to skin and manifest themselves as abscesses, pyoderma, eczema or draining sinuses. The disease was first reported in 1957 and thereafter the biomolecular mechanism has been found. The first report in Korea was an autopsy case in 1979 and since then there have been a few case reports. This disease is diagnosed by symptoms, such as high fever, cervical lymphadenopathy, skin nodule, lung field infiltration, periumbilical abscess, liver abscess, pyoderma and pericordal abscess. The pathogen here were catalase producing bacteria and fungi. However, we have experienced a case of CGD, in which symptoms were perianal, scrotal abscesses and lung field nodular infiltration. In this case the pathogen was found as a catalase negative Enterococcus.
Key Words: Chronic granulomatous disease, Catalase negative Enterococcus


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