| Correlation between Plasma Endothelin-1 Concentrations and Pulmonary Hypertension Associated with Congenital Heart Defects |
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Sang Ook Park, Su Eun Park, Hyang Jae Yoo, Young Tak Lim, Hee Ju Park |
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Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea |
| 선천성 심질환을 가진 환아에서 폐동맥 고혈압증과 혈중 Endothelin-1과의 상관 관계 |
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박상욱, 박수은, 유황재, 임영탁, 박희주 |
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부산대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Endothelin-1 is the most potent vasoconstrictor. This study was investigated the
correlation of plasma endothelin-1 and pulmonary hypertension associated with congenital heart
defect.
Methods
: We evaluated the concentration of ET-1 in 24 cases of congenital heart disease diagnosed
at the Department of Pediatrics, Pusan National University, from December 1993 to September 1994.
The patients were divided into 2 groups according to mean pulmonary arterial pressure: Pulmonary
artery hypertension group(Group Ⅰ) and normal pulmonary artery pressure group(Group Ⅱ).
Between 2 groups, there was no statistical significance in mean age, sex and oxygen saturation.
GroupⅠ included 9 patients of VSD and 1 patient of COA. Group Ⅱ included 9 patients of VSD,
3 patients of TOF and 1 patient of PS, 1 patient of PS with DORV.
Results
: The results were summarized as follows;
1) The mean pulmonary arterial pressure and pulmonary-to-systemic flow ratio (Qp/Qs), pulmonary
vascular resistance in GroupⅠwere significantly higher than those in Group Ⅱ.
2) The plasma concentrations of ET-1 in GroupⅠ was significantly higher than those in Group Ⅱ.
3) But there were no statistical significance between the concentrations of ET-1 and the mean
pulmonary artery pressure, Qp/QS, pulmonary vascular resistnace.
Conclusion
: Based on these results, plasma ET-1 concentraions were elevated in patients with
pulmonary hypertension associated with congenital heart defects. |
| Key Words:
Endothelin-1, Pulmonary hypertension, Congenital heart defect |
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