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Case Report
Severe dapsone hypersensitivity syndrome in a child
So Yoon Choi, Ho Yeon Hwang, Jung Hyun Lee, Jae Sun Park, Min Soo Jang
Clin Exp Pediatr. 2013;56(6):260-264.   Published online June 21, 2013

Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-old Korean boy who initially presented with high fever, a morbilliform...

Review Article
Impact of attachment, temperament and parenting on human development
Yoo Rha Hong, Jae Sun Park
Clin Exp Pediatr. 2012;55(12):449-454.   Published online December 20, 2012

The purpose of this review is to present the basic concepts of attachment theory and temperament traits and to discuss the integration of these concepts into parenting practices. Attachment is a basic human need for a close and intimate relationship between infants and their caregivers. Responsive and contingent parenting produces securely attached children who show more curiosity, self-reliance, and independence....

Original Article
Clinical characteristics of children with 2009 pandemic influenza A (H1N1) admitted in a single institution
Sang In Park, Min Ji Kim, Ho Yeon Hwang, Chi Eun Oh, Jung Hyun Lee, Jae Sun Park
Clin Exp Pediatr. 2010;53(10):886-891.   Published online October 31, 2010

This study aims to investigate the clinical characteristics of children diagnosed with the novel influenza A (H1N1) in the winter of 2009 at a single medical institution.


Out of 545 confirmed cases of influenza A (H1N1) in children, using the real time RT-PCR method at Kosin University Gospel Hospital from September to December of 2009, 149 patients and their medical records...

Case Report
A case of Niemann-Pick disease type A
Ho Yen Yu, Ji Eun Oh, Jae Sun Park, Mi Hyang Kim, Sin Dong Kim, Kyung Soon Jung
Clin Exp Pediatr. 2006;49(12):1358-1362.   Published online December 15, 2006
Niemann-Pick disease is a group of autosomal recessive disorders associated with hepatosplenomegaly, variable neurologic deficits, and the storage of sphingomyelin and other lipids. Seven cases have been reported in Korea. We report an additional case presenting with hypotonia, early neurodevelopmental delay, hepatosplenomegaly and death by persistent pneumonia and asphyxia at the age of 23 months. MRI of brain and fundoscopic...
A Case of Rothmund-Thomson Syndrome with Pure Red Cell Aplasia, Autoimmune Hemolytic Anemia and Chronic Respiratory Infection
Jung Hyun Lee, Eun Seok Roh, Yoo Rah Hong, Jae Sun Park, Ghi Seok Seo, Bang Hur, Mi Hyang Kim
Clin Exp Pediatr. 2004;47(12):1351-1355.   Published online December 15, 2004
Rothmund-Thomson syndrome(RTS), or poikiloderma congenita, is a rare, multisystem disorder. It is inherited genetically as an autosomal recessive trait, occurring predominantly in females(1.4 : 1). The RTS is comprised of poikiloderma, short stature, sparse hair, juvenile cataracts, skeletal defects, dystrophic teeth and nails, photosensitivity, and hypogonadism. We report a case of RTS who died of bleeding from esophageal varices, pulmonary...
Original Article
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
Clin Exp Pediatr. 2004;47(12):1319-1324.   Published online December 15, 2004
Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel...
A Five-year Epidemiologic Study of Childhood Leukemia in Busan City, 1996 to 2000
Jae Hoon Moon, Soon Yong Lee, Jong Beom Sinn, Jae Sun Park, Young Ho Lee, Young Tak Lim, Su Eun Park
Clin Exp Pediatr. 2003;46(10):972-976.   Published online October 15, 2003
Purpose : For the control of childhood leukemia, of which the mortality is still high, the basic data for the incidence has a great importance. The authors analyzed the data from 133 new patients with childhood leukemia between 1996-2000 in Busan, Korea. Methods : The data were obtained from 133 new cases(87 males and 46 females from 0 to 15 years...
Case Report
A Case of Secondary Hemosiderosis and Hepatic Fibrosis in a Pateint with Acute Myelogenous Leukemia
Hyoung No Kim, Jae Won Huh, Jae Sun Park
Clin Exp Pediatr. 1998;41(3):420-424.   Published online March 15, 1998
Chronic iron overload is associated with life-threatening complications, such as cardiomyopathy, liver cirrhosis, diabetes, hypothyroidism, hypoparathyroidism and hypogonadism. We experienced a case of secondary hemosiderosis with hepatic fibrosis in a 8-year-old boy who had been transfused 56 pints of packed red blood cells for a supportive therapy of acute myelogenous leukemia for a 27-month period. Intramuscular injection of Desferroxamine(40mg/kg/day) was...
Original Article
Immunogenicity of a Recombinant Hepatitis B Virus Vaccine Compared With a Plasma-derived Hepatitis B Vaccin~ and of Vaccination Schedules in Neonates
Ae Sil Kang, Jong Sin Kim, Jae Won Huh, Chang Youn Lee, Hyun Gi Jung, Jae Sun Park, Kwang Soo Hwang
Clin Exp Pediatr. 1995;38(11):1525-1534.   Published online November 15, 1995
Purpose : Hepatitis B virus (HBV) vaccine was developed against HBV infection, and used widely in the world. The plasma-derived HBV vaccine was prepared from the plasma of chronic hepatitis B virus carrier. But, the plasma-derived HBV vaccine had many kinds of problems, such as the limitation of source, expensiveness, and the possibility of infection which spread through blood. To avoid these...
Clinical Analysis of 29 Cases of Germ Cell Tumor in Children
Tae Geun Song, Gyeong Ah Lee, Jae Sun Park
Clin Exp Pediatr. 1994;37(3):390-396.   Published online March 15, 1994
Germ cell tumors(GCT) are not infrequently encounted tumor in pediartic age group. In order to study the clinical behaviors of the disease, we reviewed 29 cases of GCT diagnosed and treated at Kosin Medical Center in the period of 7 years from Jan. 1984 to Dec. 1991 and the results are summarized as follows: 1) The age distriution is the highest...
Case Report
Two Cases of Doxorubicin-induced Dilated Cardiomyopathy
Jin Won Park, Kyeong Ah Lee, Yong Woon Paik, Hyun Kee Chung, Jae Sun Park
Clin Exp Pediatr. 1992;35(6):822-828.   Published online June 15, 1992
Doxorubicin is an anthracycline antibiotic with a broad spectrum of activity in human neoplasms. However, this agent may cause, frequently, irreversible congestive left ventricular failure. We have experienced 2 cases of doxorubicin induced cardiomyopathy in one patient with multiple eosinophilic granuloma and another patient with T cell leukemia. Total dosage of doxorubicin was 295 mg/M2 for the 6 months duration and...
Original Article
Acute Appendicitis in Children
Min Hang Kim, Tae Geun Soon, Jae Sun Park, Chung Han Lee
Clin Exp Pediatr. 1992;35(1):51-59.   Published online January 15, 1992
A retrospective study was performed with 61 cases of acute appendicitis in children under the age of fifteen years in Kosin Medical Center from January, 1980 to April, 1991. All the patients had received surgery and biopsies of resected appendices were proved to the histological diagnosis of appendicitis The following results were obtained 1) The overall incidence of acute appendicitis...
A Case of Pancreatoblastoma with Metastasis of the Liver.
Dae Sung Oh, Yong Won Paik, Jae Sun Park, Kyung Hyun Choi, Man Ha Huh
Clin Exp Pediatr. 1990;33(5):684-689.   Published online May 31, 1990
We experenced a case of pancreatoblastoma in a 6 years old Korean male who was admmited to the pediatric department because of an abdominal mass and pathologically diagnosed following surgical removal. Microscopically, the resected mass was composed of small sized tumor cells arranged in glandular or acini structure with multifoci of squamoid corpuscle. Extensive hemorrhagic necrosis was another feature. Ultrastructucturally, two types of cells, dark...
A Case of Agnogenic Myeloid Metaplasia.
Min Sook Um, Jo Sam koo, Jae Sun Park, Sook Ja Park, Hae Kyung Jang
Clin Exp Pediatr. 1988;31(11):1486-1493.   Published online November 30, 1988
Agnogenic myeloid metaplasia characterized by marrow fibrosis, leukoerythroblastic anemia, extramedullary hematopoiesis with varying degree of hepatosplenomgaly, is very rare disorder in children. We experienced a case of agnogenic myeloid metaplasia 34 months old male patient who was presented with pallor, generalized petechiae, marked hepatosplenomegaly and intermittent fever. Peripheral blood smear showed leukoerythroblastosis, poikilocytosis and tear drop cells. Bone marrow aspiration and biopsy showed fibrosis with no...
Clinical Analysis of Brain Tumors in Children.
Ki Ji Lee, Eun Sook Choi, Jae Sun Park, Tae Sang Chun, Robert H Kyle, Hwa Dong Lee, Bang Hur, Man Ha Hur
Clin Exp Pediatr. 1987;30(2):191-200.   Published online February 28, 1987
Brain tumors are the second most common tumors in pediatric age groups. 22 cases of child brain tumors diagnosed by CT and operation at Kosin medical center in the period of 7 years from Jan. 1979 to Dec. 1985 were reviewed and the result were as follows. 1) The age distribution of brain tumor is the highest between 5 and 10 years (14/22), and...
A Clinical Study of Neuroblastoma.
Jung Sook Hong, Yang Dong Park, Il Whan Kim, Hyun Gi Jung, Jae Sun Park
Clin Exp Pediatr. 1987;30(1):80-88.   Published online January 31, 1987
17 Cases of neuroblastoma diagnosed and treated at the Kosin Medical College from Mar. 1978 toFeb. 1985 were analyzed and the results are as follows: 1) Ages at the time of diagnosis were from 7 months to 9 years. The mean age was 3 10/12 years. 29.4% of the patients were below the age of 2 and 82.3% of the...
A Study of Frequency of Malignant Tumors in Children.
Yang Dong Park, Eun Sook Choi, Hyun Gi Jung, Jae Sun Park
Clin Exp Pediatr. 1986;29(10):1130-1137.   Published online October 31, 1986
315 cases of malignant tumors under 15 years of age who were admitted to the Gospel Hospital from January 1975 to December 1984 were analysed and following results were obtained. 1) The incidence of malignances in all admitted child patient was 3.39%. 2) Childhood malignant tumors were more frequently occured in the age group of 0〜5 years. The more prevalent tumors for the...
Clinical Study of 29 Patient of Wilms Tumor.
Eun Sook Choi, Yang Dong Park, Hyun Gi Jung, Jae Sun Park
Clin Exp Pediatr. 1986;29(8):855-861.   Published online August 31, 1986
29 cases of Wilms tumor treated at the Kosin Medical Center from 1975 to 1984, were analyzed and the results are as follows: 1) The age distribution of Wilms tumor was between 4 months and 13 years. The mean age was 3 years and 9 months. The median age was 24 months. 2) There were 16 cases of left-sided tumor, 12...
Case Report
Adrenal Cortical Adenoma Associated with Spinal Epidural Lipomatosis and Paraplegia.
Il Whan Kim, Chul Hoe Koo, Jae Sun Park, Sung Uhn Baek, Sung Do Lee, Kyu Ho Lee, Jae Do Kim, Bang Hur, In Sun Jun
Clin Exp Pediatr. 1986;29(7):784-790.   Published online July 31, 1986
A 14 year old girl was admitted because of severe obesity, respiratory difficulty and weakness of legs with edema. Diagnosis of Cushing* s syndrome by left adrenal adenoma was made by hormonal assay, abdominal C-T and surgery. 1 week after adrenalectomy, she developed paraplegia which was caused by massive deposition of fat in the spinal epidural space and compression of thoracic spinal cord. She was...
A Case of Aplastic Anemia Following Hepattitis.
Jung Sik Min, Il Whan Kim, Yun Ju Jung, Hyun Gi Jung, Jae Sun Park
Clin Exp Pediatr. 1985;28(3):293-296.   Published online March 31, 1985
We experienced a case of aplastic anemia following hepatitis in a 8 year and 5 month old boy. The boy who has past history of hepatitis 10 weeks prior to this visit was admitted because of pale face with petechia on the skin of abdomen and left arm for a month. CBC and bone marrow aspiration on admission showed pancytopenia...
Two Cases of Gaucher's Disease in Brothers.
Jeong Sick Min, Il Whan Kim, Dae Young Hwang, Hyun Gi Jeong, Jae Sun Park, In Sun Jun, Man Ha Huh
Clin Exp Pediatr. 1984;27(6):628-634.   Published online June 30, 1984
We experienced 2 cases of Gaucher' s disease of adult type in brothers when their ages were 4 year 1 month and 3 year 10 month respectively. They showed remarkable hepatosplenomegaly with mild hematologic complications and characteristic histiocytoid cells in the spleen and liver biopsies. Splenectomy was followed by improvement of anemia and labored respiration in both patients. In case...
A Case of Cornelia De Large Syndrome.
Do Seung Lee, Dae Young Hwang, Jeong Sick Min, Jae Sun Park
Clin Exp Pediatr. 1983;26(6):616-621.   Published online June 30, 1983
We have experienced a case of1 Cornelia de Lange Syndrome in a male infant. At first visit, the patient showed typical appearance of microcephaly, cleft palate, generalized hirsutism and growth retardation due to poor sucking since birth. The face of the patient was characterized by micrognathia, antirrongolism slant of eyes, synorphys of eye brows, bushy forehead and bushy lateral aspect of both cheeks, all...
A Case of Klippel-Trenaunary-Weber Syndrome.
Do Seung Lee, Dae Yong Hwang, Jeong Sick Min, Jae Sun Park
Clin Exp Pediatr. 1983;26(5):516-520.   Published online May 31, 1983
We report a case of Klippel-Trenaunay-Weber Syndrome in a 12 years old boy who had large port-wine hemangioma, soft tissue & bony hypertrophy and varicose veins on the lower leg. On the skin lesion, there are several black papules & crops of skin colored eruptions which were found out microscopically to be intraepidermal bleeding focuses & harmatomatous change of squamous cells into sebaceous cells...
Original Article
Clinical Analysis of Cervical Masses in Infants and Children.
Dae Young Hwang, Do Seung Lee, Jeung Sick Min, Jae Sun Park
Clin Exp Pediatr. 1983;26(4):366-372.   Published online April 30, 1983
Cervical masses are encountered frequently in pediatric practice. Hardly an upper respiratory infection occurs without lymphadenopathy and many of these enlarged lymph nodes persist for disturbingly long periods of time. Scattered among these innocent cervical masses are those which ultimately are found to be dangerous. Sooner or later, the persistent cervical mass becomes a problem in diagnosis and treatment.In order...
Case Report
A Case of Cushing's Syndrome Associatied with Hypertensive Encephalopathy.
Choong Rae Kim, In Soon Park, Do Seung Lee, Jae Sun Park, Kee Ryo Chang, Soon Yong Lee
Clin Exp Pediatr. 1981;24(1):80-84.   Published online January 15, 1981
A 8-yrs-old boy was admitted because of convulsion and coma. The diagnosis of Cushing's syndrome(key word) associated with hypertensive encephalopathy(key word) due to right adrenocortical carcinoma(key word) was made by clinical features, biochemical studies, radiological studies and pathological examination. The tumor was successfully resected by right adrenalectomy. But 22 months later after operation, he died of dyspnea and heart failure....
Two Cases of Kartageneranjx Syndrome in Siblings.
Jae Sun Park, Won Yong Kim, Soon Yong Lee
Clin Exp Pediatr. 1977;20(3):226-230.   Published online March 31, 1977
Two cases of Kartageneranjx syndrome were presented. They were sisters in the same family and were 15 years and 13 years old respectively. Chief complaints of the first case were chronic cough and expectoration and of the second case were chronic cough, expectoration and nasal stuffiness. Situs inversus, bronchiectasis and paranasal sinusitis were identified in both cases. EKG showed typical...
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