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Original Article
Neonatology (Perinatology)
Effect of vitamin E supplementation on bilirubin levels in infants with hyperbilirubinemia: a double-blind randomized clinical trial
Mojtaba Cheraghi, Maziar Nikouei, Majid Mansouri, Siros Hemmatpour, Yousef Moradi
Clin Exp Pediatr. 2024;67(5):249-256.   Published online March 26, 2024
Question: Is vitamin E a viable therapeutic option for managing neonatal hyperbilirubinemia?
Finding: This randomized clinical trial examined the effects of oral vitamin E supplementation on bilirubin reduction (primary outcome), phototherapy duration, and length of hospital stay (secondary outcome) in 138 infants.
Meaning: Infants administered vitamin E versus placebo demonstrated similar reductions in bilirubin levels and length of hospital stay.
Effect of Vitamin E on Cerebral Hypoxia-Ischemia in Neonatal Rats
Jung Eun Seok, Yeon Kyun Oh, Seung Taek Park
Clin Exp Pediatr. 2001;44(7):764-772.   Published online July 15, 2001
Purpose : In order to evaluate the hypoxia-ischemia induced neurotoxic effect and the protective effect of vitamin E as an antioxidant, cell number and cell viability were measured in cerebral neurons and astrocytes derived in neonatal rats. Methods : 7-day old neonatal rats were subjected to unilateral common carotid artery occlusion, and exposed to hypoxic condition for 3 hours. The protective...
The Protective Effect of Vitamin E and Desferrioxamine on Cultured Cerebral Neurons of Neonatal Mouse Damaged by Ischemic Condition
So-ra Lee, Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1999;42(10):1426-1433.   Published online October 15, 1999
Purpose : Perinatal asphyxia is an important cause of neurologic morbidity. Experiments in animal models of hypoxic-ischemic brain injury demonstrate that brain damage starts during hypoxia-ischemia. In order to evaluate the ischemic condition-induced neurotoxic effect in view of oxi- dative stress, we examined the cytotoxic effect in cultured cerebral neurons of neonatal mouse. Methods : Dissociated cell cultures were prepared...
The Effect of Oral Vitamin E on Hemolytic Anemia of the Premature Infants.
Hwa Kyoung Oh, Kwang Sik Yoo, Yong Sil Chi, Myung Jin Kim, Mi Na Lee
Clin Exp Pediatr. 1989;32(11):1469-1473.   Published online November 30, 1989
The study was designed to evaluate the effect of vitamin E on hemolytic anemia of premature infants. Sixty infants delivered in Cheil Hospital from March 1987 to December 1988 with birth weight below 2500 gm or gestational age below 37 weeks were studied. Thirty infants received oral vitamin E 25 IU/day until their birth weight doubled. Thirty infants served as control. The results were...
A study on Serum Vitamin E and HDL-Cholesterol Level in Mother and Newborn.
Jae Keun Yoon, Chul Wun Park, Hye Jin Suh, Im Ju Kang, Chung Chul Kim, Tae Ho Chung
Clin Exp Pediatr. 1984;27(1):25-32.   Published online January 31, 1984
A significant redistribution of cholesterol in lipoproteins following ingestion of large doses of vitamin E is documented. Especially vitamin E has been reported to increase serum high density lipoprotein(HDL) cholesterol. The inverse relationship between HDL-cholesterol and risk of develoing coronary disease was well known. Present study was undertaken to determine whether the corelation between vitamin E and HDL-cholesterol was significant in...
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