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Case Report
Bilateral paroxysmal hemicrania with autonomic features in a child: A case report
Young Il Rho
Clin Exp Pediatr. 2009;52(5):619-621.   Published online May 15, 2009
Paroxysmal hemicrania (PH) is rare in children and not widely recognized. It is characterized by pain attacks and associated symptoms and signs similar to those experiencing cluster headaches, but the features have a shorter effect, are more frequent, and respond completely to indomethacin. Some patients with PH may experience slight pain across the midline. There are only four cases of...
Original Article
Delayed closure effect in preterm infants with patent ductus arteriosus
Hyun Ju Lee, Gyu Hong Sim, Kyung Eun Jung, Jin A Lee, Chang Won Choi, Ee Kyung Kim, Han Suk Kim, Beyong Il Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2008;51(10):1065-1070.   Published online October 15, 2008
Purpose : This study aims to determine whether early closure (within 7 d) of significant patent ductus arteriosus (PDA) with indomethacin or ligation reduces neonatal morbidity when compared with delayed closure (after 7 d). Methods : Fifty-eight extremely-low-birth-weight infants admitted to the NICU of Seoul National University Hospital from April 2005 to May 2007 with PDA were studied retrospectively. Results :...
The pharmacological treatment of patent ductus arteriosus in premature infants with respiratory distress syndrome: oral ibuprofen vs. indomethacin
Soo Jin Lee, Ji Young Kim, Eun Ae Park, Sejung Sohn
Clin Exp Pediatr. 2008;51(9):956-963.   Published online September 15, 2008
Purpose : Indomethacin is widely used for the prophylaxis and treatment of patent ductus arteriosus (PDA); however, it is associated with side effects such as renal failure, intraventricular hemorrhage, and gastrointestinal bleeding. Intravenous ibuprofen has been shown to be as effective as indomethacin in prompting PDA closure. If treatment with oral ibuprofen is as effective as indomethacin, it would have...
The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus
Min Jeong Yoon, Hye Sun Yoon, Sung Hoon Chung, Mi Young Han, Chong Woo Bae
Clin Exp Pediatr. 2007;50(6):531-535.   Published online June 15, 2007
Purpose : Indomethacin treatment is successful in about 90% of patent ductus arteriosus (PDA) in premature infants, but in some, repeated administration or surgical closure is required. The object of the present study is to determine the factors affecting the efficacy of indomethacin treatment and to predict the treatment result. Method : The 29 preterm neonates, admitted to neonatal intensive...
The effects of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants
Wooksun Choi, Jung-Yeon Shin, Byung Min Choi, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2006;49(12):1315-1323.   Published online December 15, 2006
Purpose : This study was conducted to compare the efficacy and safety of ibuprofen and indomethacin in the treatment of patent ductus arteriosus (PDA) in preterm infants and to determine whether ibuprofen can be an alternative drug. Methods : A total of 32 preterm infants with symptomatic PDA were enrolled in the study. Twelve infants received intravenous ibuprofen 10 mg/kg, followed...
Effect of prophylactic indomethacin in extremely low birth weight infants
Bo Lyun Lee, Su Jin Kim, Soo Hyun Koo, Ga Won Jeon, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2006;49(9):959-965.   Published online September 15, 2006
Purpose : The purpose of this study was to investigate the effect of prophylactic indomethacin on reduction of patent ductus arteriosus(PDA) and intraventricular hemorrhage(IVH) in extremely low birth weight infants(ELBWI). Methods : Retrospective review of 84 ELBWI who were admitted to our neonatal intensive care unit from June 2004 to April 2006 was performed. Patients were divided into prophylactic group(n=28) and...
Comparison of Clinical Courses According to the Existence of Patent Ductus Arteriosus in Respiratory Distress Syndrome
Ju Hee Seong, Hyeon Joo Lee, Hyun Kee Hong, Chong-Woo Bae, Yong-Mook Choi
Clin Exp Pediatr. 2003;46(11):1080-1084.   Published online November 15, 2003
Purpose : To compare perinatal characteristics, clinical courses, and overall morbidity between respiratory distress syndrome(RDS) with patent ductus arteriosus(PDA) and RDS without PDA in neonates. Methods : Eighty-three neonates who were diagnosed and treated for RDS in the neonatal intensive care unit(NICU) from Jan. 2000 to Dec. 2002 were included in this study. RDS was complicated with PDA(group A) in...
A Comparative Study of the Effects of Intravenous Indomethacin and Oral Mefenamic Acid in the Treatment of Premature Infants with Patent Ductus Arteriosus
Hae Jung Park, Yoon Suk Jung, Nam Soo Kim, Chang Ryul Kim, Hyuk Kim, Soo Jee Moon
Clin Exp Pediatr. 2001;44(1):32-39.   Published online January 15, 2001
Purpose : For the management of patent ductus arteriosus(PDA) in premature infants, fluid restriction, correction of anemia, mechanical ventilation, diuretics, and surgery have been used, and the closure rate of PDA has improved significantly since the introduction of indomethacin and mefenamic acid as pharmacologic treatments of PDA. We studied to evaluate and compare the therapeutic effects of indomethacin and mefenamic...
Study on Closing Time after Indomethacin Administration in Prematurity with Patent Ductus Arteriosus
Wan Cho, Suk Min Choi, Kyu Hyung Lee
Clin Exp Pediatr. 1999;42(11):1508-1515.   Published online November 15, 1999
Purpose : In the clinical field, the closing time of patent ductus arteriosus(PDA) varies among patients after indomethacin administration. We tried to predict it by analyzing related factors, and also by understanding what affects it. Methods : Among 30 cases of PDA at the NICU, 24 cases(male 14 cases, female 10 cases) were selected. Fifteen cases closed early(within 36 hours) and...
Comparison of Treatment Course and Outcome between Medically and Surgically Treated Patent Ductus
Jeong Geun Kim, Jeong Nyun Kim, Dong Chul Park, Shin Yeong Lee, Hyun Chul Lee, Myung Jae Chey, Churl Young Chung,
Clin Exp Pediatr. 1998;41(10):1334-1341.   Published online October 15, 1998
Purpose : Early intervention is needed to treat patent ductus arteriosus(PDA) as it is a major cause of increased mortality in preterm infants. However, it is uncertain which is better, medical versus surgical management. We reviewed medical records to compare the treatment course and outcome between medically and surgically treated preterm PDA infants. Methods : Thirth-two Mechanically ventilated pretem infants(gestational age<34...
Comparison of Continuous versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(5):599-605.   Published online May 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to...
Comparison of Continuous Versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(4):464-470.   Published online April 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to the infusion method, continuous...
Indomethacin-induced Changesin Renal Blood Flow and Prostaglandin E Excretion in the Cat
Yoon Suck DSuh, Dae Hun Pee, Jae Young Kim, Yu In Park, Kee Hwan Yoo, Joo Won Lee
Clin Exp Pediatr. 1997;40(9):1275-1284.   Published online September 15, 1997
Effect of Indomethacin Therapy in Prematurity with Patent Ductus Arteriosus:study of Its Effectiveness in Treatment Modality
Yun Kyeong Bae, Seong Woo Roh, Min Jeong Kim, Son Sang Seo
Clin Exp Pediatr. 1996;39(9):1239-1246.   Published online September 15, 1996
Purpose : Conventional indomethacin therapy(0.2mg/kg every 12 hours for three doses) has been used for closure of PDA. The effect of prolonged low dose of indomethacin therapy(0.1mg/kg daily for six days)had been reported in foreign country but, nothing had been reported in our country. So we attempted this study to examine effects of these two methods. Methods : Forty one infants with PDA of...
Effect of Cyclosporin, Indomethacin and Methylprednisolone on Puromycin-Aminonucleoside Induced Nephrosis in Rats
Hong Bae Kim, Hae Lee Chung, Cheol Woo Ko, Ja Hoon Ko, Jung Sik Gwak
Clin Exp Pediatr. 1993;36(4):495-505.   Published online April 15, 1993
This experimental study was conducted to evaluate the effect of indomethacin and methylprednisolone on PAN-induced nephrosis in rats. Sprague-Dawley rats weighing 150∼200gm were used and divided into controls, group Ⅰ(PAN intraperitoneally), group Ⅱ(PAN intraperitoneally, followed by indomethacin peritoneally for 12 days), group Ⅲ(PAN intraperitoneally, followed by methylprednisolone peritoneally for 12 days) and group Ⅳ(PAN intraperitoneally, followed by cyclosporin subcutaneously for...
Indomethacin therapy in premature infants with patent ductus arteriosus.
Dug Ha Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(10):1381-1390.   Published online October 31, 1991
Patent ductus arteriosus (PDA) is a common disease that occurred in 20 〜 40 percent of premature infants. The incidence of PDA is inversely related to the gestational age and birth weight. Hemodynamically significant PDA increases the morbidity and mortality of premature infants. So, the management of PDA is one of the major problems in neonatal intensive care unit. Based on experimental animal studies,...
A case of Bartter's syndrome.
Kyu Young Lee, Byoung Soo Cho, Hah Young Lee, Jay Bernstein
Clin Exp Pediatr. 1991;34(6):849-856.   Published online June 30, 1991
Bartter’s syndrome in characterized by renal potassium wasting, hypokalemic alkalosis, hyper- reninemia, normal blood pressure and resistance to the blood pressure augmenting effect of angioten- sin, accompanied by often hypomagnesemia and increased production of certain renal prostaglandins. The primary defect in this rare disorder is considered to be a renal tubular dysfunction. We had experienced a case of Bartter’s syndrome in 9 months old...
Effects of Antenatal Indomethacin on Neonate.
Ja Ye Kim, Seung Joo Lee, Keun Lee
Clin Exp Pediatr. 1985;28(11):1066-1072.   Published online November 30, 1985
Prostaglandins play an important role in mediating uterine contractions and thus may also be involved in the triggering of premature labor and spontaneous abortion. Consequently inhibition of prostaglandin synthesis has been suggested as a potential means of inhibiting premature labor. There are many controlled studies which have described the use of indomethacin for inhibition of premature labor with success. But...
Histological Study of Ductus Arteriosus Affected by Indomethacin in the Fetal Rates.
Young Sook Jang, Chang Yeoul Jeon, Heon Sook Lee, Jung Soo Kim, Moo Sam Lee
Clin Exp Pediatr. 1983;26(8):770-777.   Published online August 31, 1983
This work was perforrred for the observation of morphological changes and beginning portion of obliteration in ductus arteriosus. And also histological findings in ductus arteriosus affected by indomethacin (4ug/kg/day) were studied. The following results were obtained. In the process of obliteration, intimal pillow became irregular with the narrowing of the lumen and loose connective tissue was frequently filled into the...
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