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- Review Article
- Incidence, causative organisms, and risk factors of bloodstream infections in pediatric liver transplant patients: a systematic review
- Mohamad Shieb, Rand Hasanain, Zara Arshad, Faisal Nawaz, Rahul Kashyap, Eric Stern
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Bacterial bloodstream infections (BSI) are the leading cause of mortality and morbidity in pediatric solid organ transplant recipients. This systematic review aimed to pool global data from leading transplant institutions and identify the overall incidence, risk factors, and causative organisms of BSI in pediatric liver transplant recipients. A systematic review of the PubMed and OVID databases was conducted from 2000... -
DOI: https://doi.org/10.3345/cep.2023.01466 [Accepted]
- Gastroenterology
- Prevalence, risk factors, and treatment of small intestinal bacterial overgrowth in children
- Yu Kyung Cho, Jin Lee, Chang Nyol Paik
- Clin Exp Pediatr. 2023;66(9):377-383. Published online August 21, 2023
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· Pediatric small intestinal bacterial overgrowth (SIBO) manifestations range from nonspecific abdominal symptoms to malabsorption or malnutrition.
· SIBO is prevalent in children and adolescents with functional abdominal pain disorders.
· Predisposing factors include disturbed intestinal motility, altered anatomy, and/or abnormal body defense systems against intestinal bacteria.
· Breath tests are safe and noninvasive.
· Treatment principles include managing predisposing conditions, nutritional support, symptom control, and antibiotics.
- Original Article
- Nephrology (Genitourinary)
- Urinary neutrophil gelatinase-associated lipocalin: a marker of urinary tract infection among febrile children
- Ji Hyun Moon, Kee Hwan Yoo, Hyung Eun Yim
- Clin Exp Pediatr. 2021;64(7):347-354. Published online October 17, 2020
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Question: Reliably diagnosing urinary tract infection (UTI) in febrile children is often difficult. Can urinary neutrophil gelatinase-associated lipocalin (uNGAL) better predict UTI and acute pyelonephritis (APN) than serum C-reactive protein (CRP) and white blood cell (WBC) count?
Finding: uNGAL better facilitated the prediction of UTI and APN, than serum CRP and WBC counts in febrile children.
Meaning: uNGAL is a suitable biomarker for UTI and APN in febrile children.
- Cardiology
- Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children
- Na Hyun Lee, Hee Joung Choi, Yeo Hyang Kim
- Clin Exp Pediatr. 2017;60(4):112-117. Published online April 25, 2017
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Purpose The aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD.
Methods Serum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as...
- Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: a single center's experience
- Jungpyo Lee, Hyeeun Kwon, Joon Soo Lee, Heung Dong Kim, Hoon-Chul Kang
- Clin Exp Pediatr. 2015;58(7):251-255. Published online July 22, 2015
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Purpose The widespread introduction of bacterial conjugate vaccines has decreased the risk of cerebrospinal fluid (CSF) pleocytosis due to bacterial meningitis (BM) in children. However, most patients with CSF pleocytosis are hospitalized and treated with parenteral antibiotics for several days. The bacterial meningitis score (BMS) is a validated multivariate model derived from a pediatric population in the postconjugate vaccine era and...
- Analysis of neonatal sepsis in one neonatal intensive care unit for 6 years
- Peter Chun, Seom Gim Kong, Shin Yun Byun, Su Eun Park, Hyung Du Lee
- Clin Exp Pediatr. 2010;53(4):495-502. Published online April 15, 2010
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Purpose : Sepsis is a significant cause of morbidity and mortality in the newborn, particularly in preterm. The objective of this study was to analyze the incidence rate, causative pathogens and clinical features of neonatal sepsis in one neonatal intensive care unit (NICU) for 6 years. Methods : This study was retrospectively performed to review the clinical and laboratory characteristics including sex, gestational age,... -
- Review Article
- Antibiotics for bacterial pneumonia in children
- Hye-yung Yum
- Clin Exp Pediatr. 2009;52(3):283-288. Published online March 15, 2009
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Pneumonia remains the leading cause of mortality in children. Diagnosis depends on a combination of factors, including clinical assessment, radiological and laboratory findings. Although Streptococcus pneumoniae remains the most important cause of childhood bacterial pneumonia, the great majority of cases of community-acquired pneumonia (CAP) are of viral etiology. A new, rapid, and inexpensive test that differentiates viral from bacterial pneumonia... -
- Original Article
- Bacterial meningitis in children experienced at a university hospital, 1993-2006
- Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
- Clin Exp Pediatr. 2008;51(10):1077-1084. Published online October 15, 2008
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Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients... -
- A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005
- Yong Joo Lee, Soo Jin Lee, Ho Jin Park, Young Hyuk Lee, So Young Kang, Young Chang Kim, In Kyu Lee, Kyung Yeon Lee, Keon Su Lee, Won Seop Kim
- Clin Exp Pediatr. 2007;50(2):157-162. Published online February 15, 2007
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Purpose : The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area. Methods : We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals... -
- Clinical Entities and Etiology of Invasive Bacterial Infections in Apparently Healthy Children
- Joon Ho Lee, Eun Kyoung Song, Jin A Lee, Nam Hee Kim, Dong Ho Kim, Ki Won Park, Eun Hwa Choi, Hoan Jong Lee
- Clin Exp Pediatr. 2005;48(11):1193-1200. Published online November 15, 2005
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ilus influenzae has been declined to 4% each from 23% and 14%, respectively, compared to previous study. S. agalactiae was the most common isolate in the infants ≤3 months. Among the infants and children aged 3 months to 2 years and children of 2-5 years, S. pneumoniae(57%, 52%, respectively, in each group) was the most common isolates followed by S.... -
- Bacteremia in Pediatric Cancer Patients : Causative Organisms and Antibiotic Sensitivities
- Yong-Han Kim, Hyun-Dong Lee, Jeong-Ok Hah
- Clin Exp Pediatr. 2005;48(6):619-623. Published online June 15, 2005
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Purpose : Bacteremia in immunocompromised pediatric cancer patients can lead to high morbidity and mortality, if not treated early and properly. The incidence and antibiotic sensitivities to common pathogens of bacteremia in pediatric cancer patients are liable to change, according to region and time. We investigated the causative organisms and antibiotic sensitivities of bacteremia in pediatric cancer patients to assess... -
- Protein C as a Differential Marker for Bacterial Infection among Pediatric Patients with Fever
- Eun Ha Mo, In Hae Nam, Kyung Duk Park
- Clin Exp Pediatr. 2004;47(8):839-843. Published online August 15, 2004
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Purpose : This study was performed to find the clinical significance in protein C as a differential marker in the beginning stage of infection and prognosis factor in severe infection among pediatric patients who were admitted due to fever. Methods : A total of 40 pediatric patients who had temperatures higher than 37.5℃ on admission at the Department of Pediatrics,... -
- Causative Organisms in Children with Bacterial Meningitis(1992-2002)
- Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
- Clin Exp Pediatr. 2003;46(11):1085-1088. Published online November 15, 2003
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Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles... -
- Lumbar Puncture in Patients Who Experienced First Seizure with Fever
- Jung Kim, Jun Su Lee, Sang Eun Lee, Wan Suk Choi, Sung Ryoung Han, Kyunglae Cho
- Clin Exp Pediatr. 2003;46(10):1008-1012. Published online October 15, 2003
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Purpose : We aimed to ascertain whether lumbar punctures should be done to prove febrile seizure, and to study what conditions can delay or abolish lumbar puncture. Methods : This retrospective study was done for four years, from January, 1996 to December, 1999. The subjects were the patients who visited Masan Samsung Hospital for the first convulsion with fever, and... -
- Case Report
- A Case of Herpetic Whitlow with Bacterial Superinfection
- Ju-Young Chung, Sang-Woo Kim
- Clin Exp Pediatr. 2003;46(9):918-920. Published online September 15, 2003
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Herpes simplex virus infection of the hand in children occurs after auto-inoculation from herpetic gingivostomatitis or herpes labialis. Herpetic whitlow should be suspected based on clinical signs. Diagnosis can be made by PCR or virus culture. Many misdiagnosed cases suggests that this disease is not sufficiently known. Surgical interventions may be harmful and should be avoided. We report a case... -
- Original Article
- Predictors of Clinically Non Specific Bacterial Infection in Febrile Children Less than 3 Years of Age : WBC, ESR and CRP
- Jeong A Nho, Young Il Rho, Eun Seuk Yang, Eun Young Kim, Yeong Bong Park, Kyung Rye Moon
- Clin Exp Pediatr. 2003;46(8):758-762. Published online August 15, 2003
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Purpose : Our examination was designed to determine the diagnostic properties of the cutoff point for the prediction of bacteremia in febrile children less than 3 years of age. Cutoff point is the value that simultaneously maximizes both sensitivity and specificity. Methods : We conducted a retrospective study of febrile children, less than 3 years of age, who clinically have no... -
- A Clinical and Radiologic Study of Acute Focal Bacterial Nephritis in Children
- Kum Ho Song, Kwon Hoe Huh, Ok Yeon Cho, Jae Hoon Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Seop Lee
- Clin Exp Pediatr. 2003;46(4):351-357. Published online April 15, 2003
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Purpose : To raise awareness of the clinical importance of, and the need for proper management of acute focal bacterial nephritis(AFBN), we analyzed 22 AFBN patients and 22 other upper urinary tract infection patients by use of comparative studies. Methods : From January 2000 to May 2002, 22 AFBN patients aged from 1 month to 12 months were selected. As a... -
- Prognostic Value of Repeated Cerebrospinal Latex Agglutination Testing in Bacterial Meningitis
- Soo Jeong Lee, So Hyun Ahn, Su Jin Cho, Hae Soon Kim, Seung Joo Lee
- Clin Exp Pediatr. 2003;46(4):345-350. Published online April 15, 2003
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Purpose : Bacterial meningitis is a serious infection of childhood associated with a significant morbidity and mortality. Repeated cerebrospinal fluid(CSF) examination is a useful prognostic indicator and a delayed sterilization is associated with a higher incidence of neurologic abnormalities. In this study we tried to determine the prognostic value of repeated CSF latex agglutination testing. Methods : We retrospectively evaluated 19... -
- Usefulness of Low Risk Criteria for Serious Bacterial Infection Among Febrile Infants Younger than Three Months of Age
- So Hyun Kim, Ji Ah Jung, Hae-Soon Kim, Eun Sun Yoo, Sejung Sohn, Jeong Wan Seo, Seung Joo Lee
- Clin Exp Pediatr. 2002;45(8):967-972. Published online August 15, 2002
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Purpose : A retrospective study was undertaken to evaluate the usefulness of low risk criteria for identifying febrile infants younger than three months unlikely to have serious bacterial infection. Methods : We conducted a retrospective study of 527 infants younger than three month with a axillary temperature ≥37.4℃. If they met the following all four criteria, appear well, WBC 5,000- 20,000/mm3,... -
- A Clinical Characteristics of Systemic Candidiasis in Neonatal Intensive Care Unit : Comparison with Systemic Bacterial Infection
- Jung Hwa Lim, Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
- Clin Exp Pediatr. 2002;45(7):847-854. Published online July 15, 2002
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Purpose : Long term hospitalized infants in neonatal intensive care units(NICUs) are prone to systemic infection. It is important to differentiate systemic candidiasis from systemic bacterial infection early in the course. Thus, in this study, we have compared clinical characteristics of systemic candidiasis and systemic bacterial infection, in premature low birth weight infants. Methods : Retrospective chart review of the medical... -
- Change of Cerebrospinal Fluid Ferritin in Children with Meningitis
- Mee Hee Youm, Eun Young Kim, Young Jong Woo, Hyun Ju Park, Chan Jong Kim
- Clin Exp Pediatr. 2000;43(8):1068-1073. Published online August 15, 2000
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Purpose : Despite the advent of new and more potent antibiotics, mortality and morbidity rates due to bacterial meningitis remain stagnant. Rapid detection of microorganism and early antibiotics treatment are the most important prognostic factors of bacterial meningitis. For early diagnosis of bacterial meningitis biochemical markers such as lactic dehydrogenase, lactic acid, C-reactive proteia have been measured in cerebrospinal fluid.... -
- Isolation of Causative Microorganism and Antimicrobial Susceptibility Test in Impetigo Developed in the Past Four Years
- Hyun Jeong Lee, Sang Jung Lee, Seog Jun Ha, Chang Kyu Oh, Jin Wou Kim
- Clin Exp Pediatr. 2000;43(5):632-637. Published online May 15, 2000
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Purpose : Recently, Staphylococcus aureus has been reported as the principal microorganism isolated from impetigo, showing variable degrees of antimicrobial resistance. The aim of this work was to study the causative organism of impetigo the their antimicrobial susceptibility developed in impetigo in the past four years. Methods : We performed bacterial cultures and antimicrobial susceptibility tests in 73 patients with impetigo... -
- Diagnostic Value of Urine Latex Test In Bacterial Meningitis
- Seung Min Lee, Eun Ae Park, Seung Joo Lee
- Clin Exp Pediatr. 2000;43(1):55-59. Published online January 15, 2000
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Purpose : Bacterial meningitis in childhood carries significant mortality and morbidity, so accurate and rapid diagnosis is important. Cerebrospinal fluid(CSF) latex agglutination test has been used for rapid diagnosis of bacterial meningitis. However, urine may be the best specimen for a latex test, because bacterial antigens are concentrated in the urine. The study tried to determine the diagnostic value of urine latex test in... -
- Clinical Evaluation of Diagnostic Criteria for Early Prediction of Bacterial Infection in Febrile Neonates
- Jai Il Cho, Sang Chun Lee, Hwan Il Kim, Cheol Am Kim, Kil Seo Kim
- Clin Exp Pediatr. 1999;42(12):1661-1667. Published online December 15, 1999
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Purpose : A retrospective study was undertaken to test the hypothesis that febrile neonates, who have bacterial infections, can be accurately predicted early by diagnostic criteria. Methods : We conducted a retrospective study of 152 infants, 28 days or less of age, whose rectal temperature was at least 38℃. Past history, family history, finding on physical examinations and results of CBC,... -
- Case Report
- Three Cases of Acute Focal Bacterial Nephritis
- Yeon Soo Lim, Jae Kook Cha, Kon Hee Lee, Kwan Seop Le
- Clin Exp Pediatr. 1999;42(1):138-142. Published online January 15, 1999
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Acute focal bacterial nephritis(AFBN) is an unusual form of localized renal infection, which has various imaging findings and should be distinguished from abscess or other renal masses. Clinical symptoms are similar to other urinary tract infections but the diagnosis needs a CT or sonographic confirmation. Treatment, which is nonoperative, consists of intensive antibiotic therapy. We report three cases of AFBN... -
- Original Article
- Significance of Acute Phase Reactants(APR) Score for the Early Detection of Neonatal Bacterial Infection
- Seong Woo Kim, Myung Ho Oh, Kee Hyuk Kim, Jay G. Sim
- Clin Exp Pediatr. 1998;41(11):1491-1497. Published online November 15, 1998
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Purpose : We performed acute phase reactants(APR) test to evaluate as an appropriate screening test for the early detection of neonatal bacterial infection. Methods : We selected 174 neonates and divided into two groups; sepsis group and well-baby group. We performed APR test. Results : There are no significant difference in total leukocyte count, immature to mature rentrophil ratio, toxic granules, and... -
- The Diagnostic Value of CSF Tumor Necrosis Factor-α for Early Diagnosis of Bacterial Meningitis
- So Young Park, Soo Ja Hwang, Eun Ae Park, Jung Wan Seo, Seung Joo Lee
- Clin Exp Pediatr. 1998;41(8):1078-1083. Published online August 15, 1998
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Purpose : During the course of bacterial meningitis, TNF-α produced by macrophages and monocytes in response to LPS and other inflammatory and immune stimulation, is now recognized as a primary mediator in the pathogenesis of infection, injury and inflammation and in the process of host defence. TNF-α was increased vascular permeability by inducing morphologic and structural changes of endothelial cells... -
- C-Reactive Protein and Duration of Antibiotic Therapy in Neonatal Bacterial Infection
- Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
- Clin Exp Pediatr. 1998;41(7):901-908. Published online July 15, 1998
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Purpose : To determine whether C-reactive protein(CRP) can be used as a parameter to assess the safety of discontinuing antibiotic therapy and allows a shorter course of therapy in neonates treated for suspected bacterial infection. Methods : We have experienced 193 cases of suspected neonatal bacterial infection at Pusan Maryknoll Hospital. CRP levels were measured daily by immunonephelometry. Infants with initial... -
- Prognosis of Bacterial Meningitis based on Cerebrospinal Fluid Culture
- Yun Ju Lee, Won Sung Lee, Kyoung Sim Kim, Ki Bok Kim
- Clin Exp Pediatr. 1998;41(5):614-621. Published online May 15, 1998
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Purpose : The present study was undertaken to assess whether the results of cerebrospinal fluid (CSF) culture are related to prognosis. Methods : Subjected to this study were 51 cases admitted to our department who had been diagnosed as bacterial meningitis. They were divided into two groups, Group Ⅰ(20) with positive CSF culture and Group Ⅱ(31) with negative outcome, then both... -
- Peripheral-Blood-Based PCR Assay to Identify Patients with Childhood Tuberculosis
- Soo Sung Park, Byoung Moon Ahn, Eun Ryoung Kim, Il Soo Kim, Jae Jong Kim, Yu Jin Rha, Han Ho Park
- Clin Exp Pediatr. 1997;40(6):841-849. Published online June 15, 1997
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Purpose : There is an urgent need for rapid and accurate diagnosis of childhood tuberculosis. Recently, developments in molecular biology have raised hopes about the possibilities of new strategies for tuberculosis diagnosis. Most of these methods have focused on the application of PCR to sputum samples from patients with suspected mycobacterial disease. We used a nested PCR to detect circuclating Mycobacterial tuberculosis DNA in... -
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6.52022CiteScore92nd percentilePowered by
