Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2021.00241    [Accepted]
Published online August 23, 2021.
Promising candidate cerebrospinal fluid biomarkers of seizure disorder, infection, inflammation, tumor, and traumatic brain injury in pediatric patients
Seh Hyun Kim1  , Soo Ahn Chae1,2 
1Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea
2College of Medicine, Chung-Ang University, Seoul, Korea
Correspondence: 
Soo Ahn Chae, Email: kidbrain@cau.ac.kr
Received: 28 February 2021   • Revised: 27 June 2021   • Accepted: 11 July 2021
Abstract
Cerebrospinal fluid (CSF) is a dynamic metabolically active body fluid that has many important roles and is commonly analyzed in pediatric patients, mainly to diagnose central nervous system infection and inflammation disorders. CSF components have been extensively evaluated as biomarkers of neurological disorders in adult patients. Circulating microRNAs in CSF are a promising class of biomarkers for various neurological diseases. Due to the complexity of pediatric neurological disorders and difficulty in acquiring CSF samples from pediatric patients, there are challenges in developing CSF biomarkers of pediatric neurological disorders. This review aimed to provide an overview of novel CSF biomarkers of seizure disorders, infection, inflammation, tumor, traumatic brain injuries, intraventricular hemorrhage, and congenital hydrocephalus exclusively observed in pediatric patients.
Key Words: Biomarker, Cerebrospinal fluid, MicroRNA neurologic disorder, Pediatric patient


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