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Clinical Studies on the 88 Cases of Diphtheria

Journal of the Korean Pediatric Society 1966;9(3):159-164.
Published online May 31, 1966.
Clinical Studies on the 88 Cases of Diphtheria
Hl Soon Kim, Jong Hue Choi, Young Key Han
Department of Pediatrics,College of Medicine, Kyungpook University
디프테리아 88例에 對한 臨床的 觀察
金熙順, 崔種烋, 韓 永 基
慶北大學校 醫料大學 小兒科學敎室
Abstract
We observed 88 cases of diphtheria who were admitted to Kyungpook University Hospital during: the period of 5 years from 1959 to 1963. The summary of the clinical and laboratory findings including those of lectrocardiograms are as follows: The seasonal peak incidence of the our cases was from November to January and the age incidence was highest in the 4 to 6. years range with the sex ratio of male 1.6: female 1. According to the types of the disease,56.8% of the patients were laryngeal diphtheria, and it was most prevalent to the age group of 2 to 5 years. 27.3% was pharyngeal type and 13.6% was pharyngoloryngeal type, but there was only one case of nasal type of nasopharyngeal type. Most of the patients visited and admitted to the hospital 3 to 5 days after the initial complaints. The presenting complaints at the time of admission were as follows: Anxiety and irritability (86.4%),Hoarseness (80.7%), Dyspnea (77.3%), Elevation of the body temperature (75.0%), Cough (73.9%),and etc. The cervical lymphadenitis was not so popular as we were predicted. Pseudomembrane was detected on 43.2% of the cases, and 53.4% of the cases revealed positive results on the smear preparations taken from nasopharynx. On the peripheral blood counts, 85.5% of the patients had mild to moderate degree of anemia, and leukocytosis was detected on the 59.0% of the cases with, the range of 10,000 to 25,000/mm3. On the electrocardiograms obtained at the time of admission, abnormal tracings were detected in 37.5% of cases. Among the major abnormalities, ST segment and T wave changes were noted in 13.9%, right ventricular hypertrophy in 9.1%, left ventricular hypertrophy in 8.3%, and incomplete bundle branch block or prolongation of P-R interval were noted in 5.6% each other. Profuse amounts of diphtheria antitoxin and antibiotics were used according to the types and. severity of the patients. Tracheotomy was performed for 18 cases(20.5%) who had severe cyanosis. 28.4% of the patients showed urinary findings of nephritis. Carditis was found only a case. The other one case had soft palate paralysis and pericarditis with effusion. Bronchitis was rare and noted. only a cases of our patients. 3 cases (3.4%) were expired, 2 of those were laryngeal diphtheria and the other one was pharyngeal type with complicating carditis.


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