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Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2019.00500    [Accepted]
Published online November 22, 2019.
Increasing incidence of inflammatory bowel disease in children and adolescents: the significance of the environmental factors
Sowon Park1  , Yunkoo Kang2  , Hong Koh1  , Seung Kim1 
1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Severance Pediatric IBD Research Group, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea
2Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Wonju Severance Christian Hospital, Wonju College of Medicine, Yonsei University, Wonju, Korea
Correspondence: 
Seung Kim, Tel: +82-2-393-9118, Fax: +82-2-2228-2050, Email: PEDKS@yuhs.ac
Received: 14 May 2019   • Revised: 18 November 2019   • Accepted: 22 November 2019
Abstract
Inflammatory bowel disease is a chronic relapsing immune-mediated disease of the intestinal tract. Although its prevalence is investigated to be lower in Asia than in Western countries, the rapid increase in the incidence rate of inflammatory bowel disease has drawn attention to the etiology of inflammatory bowel disease, including genetic susceptibility and environmental factors. Specifically, recent studies concerning dietary treatments and intestinal microbiota suggest that these factors may interact with the immune system, and the imbalance of this relationship may lead to the immune dysregulation in inflammatory bowel disease. The changes in diet or alteration in the composition of intestinal microbiota may be associated with the increasing incidence of inflammatory bowel disease in Asia. Here, we aim to review the recent studies on the role of the diet and intestinal microbiota in inflammatory bowel disease pathogenesis and the results of the investigations performed to modulate these factors.
Key Words: Inflammatory bowel disease, Diet, Microbiota, Fecal microbiota transplantation




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