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Laboratory and Clinical Study of Ceftizoxime Sodium (Epocelin(R)) in Infections of the Pediatric Age Group.

Journal of the Korean Pediatric Society 1984;27(7):685-701.
Published online July 31, 1984.
Laboratory and Clinical Study of Ceftizoxime Sodium (Epocelin(R)) in Infections of the Pediatric Age Group.
Keun Soo Lee1, Hahng Lee1, Jeh Hoon Shin1, Kook Young Meng2, Dae Keun Kim2, Choon Won Kim2
1Department of Pediatrics, College of Medicine, Hanyang University
2Department of Clinical Pathology College of Medicine, Hanyang University
소아과 영역의 감염증에 대한 Epocelin® (Ceftizoximesodium) 의 기초적 및 임상적 연구
이근수1, 이황1, 신재훈1, 맹국영2, 김대근2, 김춘원2
1한양대학교 의과대학 소아과학교실
2한양대학교 의과대학 임상병리학교실
An in-vitro sensitivity of Ceftizoxime sodium (CZX), a third generation Cephalosporin, using Epocelin® (a product of Fujisawa Pharmaceutical Central Laboratory, Japan), was studied against various bacterial strains isolated from the children with infections hospitalized on the pediatric ward of Hanyang University Hospital during the period from February, 1983 up to June, 1983. And therapeutic responses were observed in 26 pediatric cases hospitalized for various types of infections when treated with CZX. The summary of the results from the study and the observation is as follows: 1)The in-vitro sensitivity test of CZX revealed high sensitivity results for S, aureus, 91.8%; E, coli, 100%; K, pneumoniae, 100%; K. oxytoca, 100%; E. cloacae, 93.2%; and C. freundii, 87.5%. 2)CZX showed intermediate sensitivity results for S. epidermis, 65.5% and Enterococci, 66.6%.3)CZX showed low or poor sensitivity results for P. aeruginosa and A. anitratus.4)The clinical therapeutic trial of CZX revealed good to excellent responses in 81% of the cases treated (21/26): excellent in 14 cases, good in 7 cases, fair in 2 cases and poor in 3 cases. The authors conclude from the laboratory and the clinical study that Ceftizoxime Sodium: Epocelin®) carries broad spectrum sensitivity and also high sensitivity for certain bacterial strains observed, and therefore, CZX is considered valuable for clinical use as a broad spectrum antibiotic agent.
Key Words: Disc sensitivity test, Therapeutic effect of ceftizoxime, A new third generation cephalosporins, Pediatric field

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