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A Clinical Observation on Systemic Lupus Erythematosus in Children.

Journal of the Korean Pediatric Society 1987;30(5):527-535.
Published online May 31, 1987.
A Clinical Observation on Systemic Lupus Erythematosus in Children.
Han Wook Yoo1, Hae Il Cheong1, Hoan Jong Lee1, Yong Choi1, Kwang Wook Ko1, Yong Il Kim2
1Department of Pediatrics, College of Medicine Seoul National University
2Department of Pathology, College of Medicine Seoul National University
소아의 전신성 홍반성 낭창에 대한 임상적 고찰
유한욱1, 정해일1, 이환종1, 최용1, 고광욱1, 김용일2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학교실
To elucidate the clinical characteristics of childhood onset systemic lupus erythematosus (SLE), we carried out a retrospective review on medical records of sixteen patients who were diagnosed as SLE on the base of “the 1982 revised criteria for the SLE” (by American Rheumatism Association) at the Department of Pediatrics, Seoul National University Children’s Hospital between January 1976 and July 1986. The results were summarized as follows; 1) Female patients outnumbered male by three to one. 2) Owing to striking diversity regarding clinical patterns, patients presented were initially diagnosed as various diseases including renal, hematologic, neurologic, infectious disease and so on. 3) The major clinical manifestations were hematologic involvement, renal involvement, malar rash, and pericarditis in order of frequency. 4) Diffuse proliferative lupus nephritis (class IV) had the highest frequency (6/13) in renal histopathologic tudies. 5) Among the immunologic tests useful in the diagnosis of SLE, FAN A (fluorescent antinuclear antibody) and anti-ds DNA antibody test revealed highest sensitivity, but LE cell test was less sensitive. 6) The serologic and hematologic parameters tended to be normalized in order of leukopenia, C3,and C4 sequentially responding to initial treatment. Conclusively, the childhood onset SLE is not so rare, though not common, and the high index of suspicion is important for accurate diagnosis due to the diversity of clinical features.
Key Words: Systemic Lupus Erythematosus in Children.

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