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Measurement of Carboxyhemoglobin in the Newborns with ABO Incompatible Hyperbilirubinemia.

Journal of the Korean Pediatric Society 1990;33(9):1188-1193.
Published online September 30, 1990.
Measurement of Carboxyhemoglobin in the Newborns with ABO Incompatible Hyperbilirubinemia.
Jung Ae Shin1, Son Moon Shin1, Jeong Ok Hah1, Chun Dong Kim2
1Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea
2Department of Pediatrics, Soon Chun Hyang Gumi Hospital, Gumi, Korea
ABO 부적합 신생아에서 과빌리루빈혈증의 발생과 Carboxyhemoglobin과의 관계
신정애1, 신손문1, 하정옥1, 김춘동2
1영남대학교 의과대학 소아과학교실
2순천향 구미병원 소아과
Received: 15 March 1990   • Accepted: 11 June 1990
Abstract
To develop more reliable screening test for ABO incompatible hemolytic disease than commonly employed and to identify possible indicators of severity of hyperbilirubinemia, a pilot study was performed by measuring the carboxyhemoglobin (HbCO) of the newborn babies within 48 hours after birth. Forty eight newborn babies were studied and carboxyhemoglobin was measured by spectro- photometry and serum bilirubin was measured by Diazo coupling method. There were significant differences of HbCO levels between hyperbilirubinemic group with ABO incompatibility and nonhyperbilirubinemic group with ABO incompatibility (1.17±0.77% vs 0.43±0. 23%) (p<0.05). There were no significant differences of HbCO levels between hyperbilirubinemic newborns and nonhyperbilirubinemic newborns of ABO compatible group (0.44±0.25% vs 0.36±0.17%). Therefore measurement of HbCO within 48 hours after birth was considered to be useful for prediction of hyperbilirubinemia in ABO incompatible newborn babies and it is necessary to monitor bilirubin levels in such newborn babies during first few days of life
Key Words: ABO incompatibility, Hyperbilirubinemia, Carboxyhemoglobin


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