Journal of the Korean Pediatric Society 1982;25(5):436-444.
Published online May 31, 1982.
Effect of Phototherapy on the Riboflavin Status in Neonatal Hyperbilirubinemia.
Young Oak Bang
Department of Pediatrics, Soon Chun Hyang College, School of Medicine, Korea.
신생아 황달의 광선치료가 riboflavin 상태에 미치는 영향
방영옥
순천향대학 의학부 소아과학교실
Abstract
Riboflavin in unstable in light and has a maximum absorption at 450nm. A study was designed to determine whether riboflavin deficiency developed in neonate who received phototherapy with eight day light bulbs for hyperbilirubinemia and to get normal value of activity coefficient of erythrocyte glutathione reductase in neonate. Twenty-seven infants who received phototherapy were investigated. Thirth-eight normal infants without phototherapy served as controls. All the infants of the two groups were fed artificially and then dialy riboflavin intake in each was more than 0.3mg. Riboflavin was determined from the degree of flavin adenine dinucleotide saturation of erythrocyte glutathione reductase, a method shown to reflect riboflavin nutritional status on the neonates. This is expressed as the activity coefficient. The mean activity coefficient of erythrocyte glutathione reductase in control group was 1.15+/-0.16. In phototherapy group, mean activity coefficient of just prior to the initiation and just after cessation of phototherapy were similar with the mean activity coefficient of control group and there was no significant increment of activity coefficient after phototherapy. There was no significant difference between the changes of activity coefficient according to light intensity. And also there was no significnat difference between the changes of activity coefficient according to duration of phototherapy and according to total phototherapeuti cdose.
Key Words: Riboflavin, Phototherapy, Neonate




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