Journal of the Korean Pediatric Society 1991;34(2):190-196.
Published online February 28, 1991.
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Department of Pediatrics, College of Medicine, Yonsei University Seoul, Korea
B형 간염 보균산모에서 태어난 신생아에서 B형 간염의 재태 및 경태반 감염에 대한 연구*
김소연, 이철, 한동관
연세대학교 의과대학 소아과학교실
Received: 5 July 1990   • Accepted: 5 October 1990
Abstract
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine between September 1986 and December 1989 were tested for HBsAg and among them, 170 (5.7%) were found to be positive. Among the 170 neonates bom to these mothers, 24 were positive for HBsAg showing a 14.1% positive rate. The average antigen titer in these infants was 2496.7 ± 5640.7cpm which was 12 times higher than the cutoff titer of 213.2±86.3cpm. Anti-HBe IgM was positive in 1 (0.6%) among these 170 neonates. Anti-HBs was positive in 17 of the 170 neonates bom to hepatitis B virus carrier mothers indicating a 10% positivity for anti-HBs. The incidence for hepatitis B virus infection was lower in neonates bom by cesarian section than by normal vaginal delivery. However the duration and stages of labor in vaginal delivery had no relation to hepatitis B antigen positivity. There was no difference between the neonates bom to carrier mothers and in the control group for duration of pregnancy, APGAR scores at 1 and 5 minutes, weight, height, head and chest circumfer- ence and presence of congenital anomalies at birth. It can be concluded that the transplacental transmission rate of HBsAg in neonates bom to HBsAg carrier mothers is 14.1%. Anti-HBc IgM was positive in 1 among 170 neonates indicating the possibility of intrauterine infection in neonates of hepatitis B carrier mothers.
Key Words: Transplacental transmission, Hepatitis B virus, anti-H Be IgM




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