| Human rhinoviruses and asthma in children |
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Woo Kyung Kim |
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Department of Pediatrics, Inje University, College of Medicine, Seoul, Korea |
| Human rhinoviruses and asthma in children |
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김우경 |
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인제대학교 의과대학 서울백병원 소아과학교실 |
Correspondence:
Woo Kyung Kim, Tel: 82-2-2270-0057, Fax: 82-2-2270-0264, Email: ped3kim@yahoo.co.kr
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| Abstract |
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Human rhinoviruses (HRVs) is a nonenveloped, single stranded RNA virus belonging to the family Picornavirudae. Transmission by direct contact such as hand-to-hand, hand-to-nose, and hand-to-eye has been readily demonstrated in experimental settings. HRV are the most frequent causes of common cold infection, however, they are also known to replicate in the lower respiratory tract and associated with more severe respiratory illnesses such as asthma. New technique such as reverse transcriptase polymerase chain reaction and molecular typing in HRV has been developed and our understanding of the importance of these respiratory viruses. HRVs consisted of 101 serotypes that are classified into groups A and B according to sequence variations. And there is a newly identified set of HRVs, called Group C, and it is currently under investigation. In recent study using PCR techniques, HRVs accounted for approximate 50-80% of common colds and 85 % of childhood asthma exacerbations and in more than half of adult exacerbations. However, the mechanisms of HRV- induced asthma exacerbations are poorly understood. This review discusses the association between HRVs and childhood asthma. |
| Key Words:
Human rhinovirus, Asthma, Polymerase chain reaction |
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