Korean Journal of Pediatrics 2009;52(5):622-626.
Published online May 15, 2009.
Kikuchi-Fujimoto disease with aseptic meningitis
Se Jin Park1, Won Jin Moon2, Wan Seop Kim3, Kyo Sun Kim1
1Department of Pediatrics, Konkuk University College of Medicine, Seoul, Korea
2Department of Radiology, Konkuk University College of Medicine, Seoul, Korea
3Department of Pathology, Konkuk University College of Medicine, Seoul, Korea
무균성 뇌수막염을 동반한 Kikuchi-Fujimoto 병
박세진1, 문원진2, 김완섭3, 김교순1
1건국대학교 의학전문대학원 소아청소년과학교실
2건국대학교 의학전문대학원 영상의학교실
3건국대학교 의학전문대학원 병리학교실
Correspondence: 
Kyo Sun Kim, Email: fli08@hanmail.net
Abstract
Kikuchi-Fujimoto disease was initially described as a self-limiting histiocytic necrotizing lymphadenitis in Japan in 1972, and is predominantly observed in women under the age of 30 year and in Asian populations. The pathogenesis is still poorly understood but is thought to include infections, and autoimmune and neoplastic diseases. The most common clinical manifestations are fever and painless cervical lymphadenitis. Diagnosis is based on the histopathological findings, characterized by focal necrosis in the paracortical region with abundant karyorrhexis, aggregates of atypical mononuclear cells around the zone of necrosis, absence of neutrophils and plasma cells, and usually intact lymph node capsule. There is no specific therapy for the condition, and aseptic meningitis can occur as one of the complications. Here, we report the case of a patient with Kikuchi-Fujimoto disease accompanied with aseptic meningitis, which may be confused as a case of tuberculous meningitis and lymphadenitis.
Key Words: Kikuchi-Fujimoto disease, Histiocytic necrotizing lymphadenitis, Aseptic meningitis


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