Korean Journal of Pediatrics 2009;52(5):544-548.
Published online May 15, 2009.
Relationship between Helicobacter pylori infection and iron-deficiency anemia in infants and children
Meong Hi Son, Jung Suk Yeom, Ji Suk Park, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn
Department of Pediatrics, The Gyeongsang National University College of Medicine, Jinju, Korea
영유아에서 Helicobacter pylori 감염과 철결핍성 빈혈과의 관계 연구
손명희, 염정숙, 박지숙, 박은실, 서지현, 임재영, 박찬후, 우향옥, 윤희상
경상대학교 의과대학 소아과학교실
Correspondence: 
Jae Young Lim, Email: pedneu@gsnu.ac.kr
Abstract
Purpose
: To elucidate a potential association between Helicobacter pylori (HP) infection and iron-deficiency anemia (IDA) in infants and children in terms of the other factors related to iron utilization and storage although the association of ferritin was previously studied.
Methods
: We evaluated 135 infants (aged 6-24 months) admitted at Gyeongsang National University Hospital from 2000 to 2006. Western blot assays using the HP CagA antigen (120 kD) were conducted to identify infections. The concentrations of six parameters were measured: hemoglobin (Hb), serum ferritin, soluble serum transferrin receptors, interleukin-6, prohepcidin, and C-reactive protein. In addition, the infants were classified into IDA, anemia from inflammation (AI), unclassified anemia (UCA), and normal groups on the basis of Hb and ferritin concentrations.
Results
: In the IDA group (n=20), seven infants were infected with HP, with the other infants showing no evidence of infection. The mean Hb levels in the IDA group were significantly lower in HP-infected infants than those uninfected (7.1 vs. 8.2 g/dL, respectively); the mean ferritin levels were also significantly lower in the infected infants (3.2 vs. 6.8 µg/L). The other four parameters did not differ significantly among the IDA infants. No correlations were found between the six parameters and HP infection status in the other groups.
Conclusion
: There were no significant differences in the HP infection rates among the study groups. However, in the IDA group, the HP-infected infants had significantly lower serum ferritin and Hb levels than the HP-negative infants (P<0.05).
Key Words: Helicobacter pylori, Inflammation, Anemia, Iron deficiency


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