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Clinical Effects of Oseltamivir in Children with Influenza in Busan, in the First Half of 2004

Korean Journal of Pediatrics 2005;48(9):976-985.
Published online September 15, 2005.
Clinical Effects of Oseltamivir in Children with Influenza in Busan, in the First Half of 2004
Soo Kyoung Park1, So Young Choi1, Sung Mi Kim1, Gil Heun Kim1, Jin Hwa Jung1, Im Jung Choi1, Kyung Soon Cho2
1Department of Pediatrics, Maryknoll Hospital, Busan, Korea
2Institute of Health & Environment, Busan, Korea
2004년 상반기에 부산 지역 소아에서 유행한 독감에서 Oseltamivir의 치료 효과
박수경1, 최소영1, 김성미1, 김길현1, 정진화1, 최임정1, 조경순2
1메리놀병원 소아과
2부산광역시 보건환경연구원
Correspondence: 
Sung Mi Kim, Email: ksm7090@hanmail.net
Abstract
Purpose
: Although influenza is one of the most important causes of acute respiratory tract infections in children, effective antiviral therapies are not common and there are only a few clinical studies on treatment of influenza in children. We evaluated the efficacy of oseltamivir in the treatment of naturally aquired influenza in children during the first half of 2004 in Busan.
Methods
: From January 2004 to June 2004, throat swabs and nasal washes were performed and cultured for the isolation of influenza virus and tested by rapid antigen detection test(QuickVue influenza test) in children with suspected influenza infections. The children who responded positively to the QuickVue influenza test, we divided into two groups : an oseltamivir treatment group and a control group. We compared their clinical symptoms(including fever duration) and diagnosis. The medical records of patients with influenza virus infection were reviewed retrospectively.
Results
: A total of 621 individuals were suspected of influenza infection. Influenza viruses were isolated in 79(17.2 percent) out of 621 patients examined. QuickVue influenza tests were positive in 181 cases. The treatment group(83 individuals) received oseltamivir twice daily for 5 days, and the control group(99 individuals) were administered only symptom relief medicine. There was no differences between the two groups in clinical diagnosis and symptoms. Oseltamivir treatment reduced the fever duration and other respiratory symptoms. There were no adverse events associated with oseltamivir treatment.
Conclusion
: Our data suggest that oral oseltamivir treatment reduces the fever duration and other respiratory symptoms of acute influenza without side effects in children.
Key Words: Influenza , Children , Antigen , Test , Oseltamivir


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