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A Case of Chronic Granulomatous Disease Which is Improved by Interferon-γ Therapy

Journal of the Korean Pediatric Society 1997;40(7):1021-1025.
Published online July 15, 1997.
A Case of Chronic Granulomatous Disease Which is Improved by Interferon-γ Therapy
Jae Choon Kim, Soon Seong Park, Myung Ja Yun, Dong Hyuk Keum
Department of Pediatrics, Kangbuk Samsung Hospital, Seoul, Korea
감마 인터페론 치료로 호전을 보인 만성 육아종 질환 1례
김재춘, 박순성, 윤명자, 금동혁
강북삼성병원 소아과
Abstract
Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis. We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient' s NBT test was less than 11%. The patient received subcutaneous injection of interferon-γ, 200 million unit(0.1mg/m2 of body surface area per dose), on three consecutive days per week for 3 weeks and her symptom was improved. Then, we report a case of chronic granulomatous disease which is improved by interferon-γ therapy with brief review of literature.
Key Words: Chronic granulomatous disease, Interferon-γ therapy


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