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Plasma Fibronectin Concentration in the Neonate

Journal of the Korean Pediatric Society 1996;39(3):319-325.
Published online March 15, 1996.
Plasma Fibronectin Concentration in the Neonate
Young Yoo, Kwang Chul Lee, Young Chang Tockgo
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
신생아 혈장 Fibronectin 농도
유영, 이광철, 독고영창
고려대학교 의과대학 소아과학교실
Abstract
Purpose
: Plasma fibronectin is thought to have important role in the inflammatory response and host defense. We performed this study to evaluate concentration in the full-term, healthy preterm, asphyxia and respiratory distress syndrome and how that correlated with gestational age and birth weight.
Methods
: We evaluate 51 neonates who were delivered at Korea University Hospital from Jan. 1992 to Jul. 1992. In order to evaluate concentration of plasma fibronectin according to gestational age and birth weight in 51 neonates, we measured plasma fibronectin in healthy premature and term infants and investigated the alteration in plasma values in infants with perinatal asphyxia and respiratory distress syndrome.
Results
: 1) The concentration of plasma fibronectin was lower in preterm infants(123¡¾30ug/dl) than in term infants(151¡¾26ug/dl). 2) There was a significant correlation between the plasma fibronectin concentration and both gestational age and weight (p<0.01). 3) The infant with perinatal asphyxia and respiratory distress syndrome had lower plasma fibronectin concentration than those in age matched healthy infant.
Conclusion
: This results shows that the plasma fibronectin correlate with gestational age and birth weight and suggests that deficiency of plasma fibronectin correlate with reticuloendothelial system hypofunction in infants with complicated birth.
Key Words: Fibronectin, Neonate


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