Furosemide-Induced Nephrocalcinosis in Very Low Birth Weight Infants

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Case Report

Journal of the Korean Pediatric Society 1994;37(4):553-559.
Published online April 15, 1994.

Furosemide-Induced Nephrocalcinosis in Very Low Birth Weight Infants

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극소체중아에서 Furosemide 투여에 의해 발생된 신석회화증 2례

박미정^¹^, 박국인^¹^, 박민수^¹^, 남궁란^¹^, 이철^¹^, 한동관^¹^, 임현이^²^, 정우희^¹

Abstract

Renal calcifications are a recognized complication of furosemide therapy in premature infants. Particularly in infants with chronic lung disease, the use of this potent diuretic is associated with hypercalciuria, which may predispose the infant to medullary nephrocalcinosis and renal calculi. We experienced two cases of nephrocalcinosis in very low birth weight infants. One had bronchopulmonary dysplasia, pneumonia, patent ductus arteriosus, ventricular septal defect and congestive heart failure and the other had systemic cytomegalovirus infection with cytomegalovirus pneumonitis and ricket of prematurity. Both patients received a large amount of furosemide. We presented these cases with brief review of literatures.

Key Words: Furosemide, Nephrocalcinosis, Very low birth weight infant