Original Article Journal of the Korean Pediatric Society 1992;35(12):1674-1682. Published online December 15, 1992.
 Clinical Application of APR score in the Detection of Neonatal Infections; Comparison of Fullterm and Premature Sei-Joon Ko1, Sang Mi Ha1, Mi Kyeung Lee2, Soon Il Lee1 1Department of Pediatrics, Sowha Childrens Hospital, Seoul, Korea2Department of Clinical Pathology, Sowha Childrens Hospital, Seoul, Korea 신생아 감염증의 조기진단에 있어서 APR 점수의 의의 -만삭아와 미숙아의 비교를 포함하여- 고세중1, 하상미1, 이미경2, 이순일1 1소화아동병원 소아과2소화아동병원 임상병리과 Abstract We measured APR scores for the 100 newborns of having suspected systemic infection prospectively, and evaluated the clinical significance of the results of the APR scores; in fullterm babies and in premature babies. The percentage of high APR score group (≥2) was 81% in fullterm and 66% in premature babies. When the results of the APR scores were compared to the bacterial culture results, the group of high APR score (≥2) was proved to have a positive cultures in 77% of fullterm, and 61% of premature babies. In contrast, the group of low APR score with systemic infection confirmed by some positive culture results was 23% in fullterm, and 39% in premature babies. We also observed some cases of showing high APR score without proven culture results in 27% of fullterm and 31% of preterm babies. Even though the results of our data do not mean final confirmation of systemic infection, we can conclude that 1) APR score may be useful for screening of early detection of systemic infection in the high risk newborns and give clues to start antibiotic therapy, 2) we must have special consideration for the premature babies to evaluating the meaning of the APR score results for they may show low APR score even in a severe infection state, 3) with the aid of the APR score we can differentiate the active infection from other non-infectious states especially in some complicated cases and can evaluate the infection progress of having long-term antibiotic therapy by follow-up check of APR score. Key Words: APR score, infection

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