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Editorial
Neurology
Perampanel is also a useful adjunctive treatment option in refractory epilepsy in children
Jon Soo Kim, Won Seop Kim
Clin Exp Pediatr. 2019;62(7):259-260.   Published online March 5, 2019
Retraction
Retraction: Mammalian target of rapamycin inhibitors for treatment in tuberous sclerosis
Won Seop Kim
Clin Exp Pediatr. 2013;56(6):269-269.   Published online June 21, 2013
Review Article
Mammalian target of rapamycin inhibitors for treatment in tuberous sclerosis
Won Seop Kim
Clin Exp Pediatr. 2011;54(6):241-245.   Published online June 30, 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the...

Original Article
The characteristics of neurocardiogenic syncope in children
Kyung Yeon Lee, Jin Young Lee, Myoung Hyun Kim, Jeong Eun Lee, Yong Dae Kim, Eun Ju Lee, Young Su Lim, Won Seop Kim
Clin Exp Pediatr. 2008;51(5):512-517.   Published online May 15, 2008
Purpose : Syncope is relatively common in children and adolescents. Among the etiologies of syncope, neurocardiogenical syncope is the most common, but it is often confounded with seizure. We investigated the clinical features of patients under the age of 15 with neurocardiogenical syncope, compared to patients with neurologic disorders including epilepsy. Methods : Among the children who visited the...
Risk Factors of Unprovoked Seizures after Acute Symptomatic Seizures in Children
Eun Ju Lee, Won Seop Kim
Clin Exp Pediatr. 2007;50(11):1097-1103.   Published online November 15, 2007
Purpose : Acute symptomatic seizure is defined as a temporary seizure together with acute systemic, metabolic, or toxic insult in association with an acute central nervous system insult. And unprovoked seizure is defined as seizure without provocating factors. We studied the risk factors of unprovoked seizures after acute symptomatic seizure in children. Methods : We retrospectively reviewed the records of...
A comparison of provoked seizures and febrile seizures associated with minor infections
Eun-Ju Lee, Won Seop Kim
Clin Exp Pediatr. 2007;50(4):376-380.   Published online April 15, 2007
Purpose : Febrile seizures occur in childhood associated with a febrile illness not caused by infections of the central nervous system. Provoked seizures are identified with seizures in association with infections that do not usually affect the brain such as gastroenteritis, except criteria for other febrile seizures in this study. We studied seizures provoked by minor extracranial infections, to contrast...
A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005
Yong Joo Lee, Soo Jin Lee, Ho Jin Park, Young Hyuk Lee, So Young Kang, Young Chang Kim, In Kyu Lee, Kyung Yeon Lee, Keon Su Lee, Won Seop Kim
Clin Exp Pediatr. 2007;50(2):157-162.   Published online February 15, 2007
Purpose : The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area. Methods : We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals...
Medical Lecture Course
Epilepsy and Oxygen Free Radicals
Won Seop Kim
Clin Exp Pediatr. 2005;48(9):920-923.   Published online September 15, 2005
Epilepsy is a neurological disorder from many molecular and biochemical responses. In the underlying mechanism, free radicals play an important role in seizure initiation and seizure-induced brain damage. Excessive production of oxygen free radicals and other radical species have been implicated in the development of seizures under pathological conditions and linked to seizure-induced neurodegeneration.
Original Article
A Clinical Study of Acute Symptomatic Seizures in Children
Kyeong Eun Lee, Won Seop Kim
Clin Exp Pediatr. 2000;43(9):1254-1262.   Published online September 15, 2000
Purpose : To determine the incidence, etiology, sex, age, seizure type and prognosis of acute symptomatic seizures in children and evaluate the hypothesis that acute symptomatic status epilepticus( SE) is associated with an increased risk of subsequent unprovoked seizure compared with the risk of acute symptomatic seizure without SE. Methods : Five hundred and sixty-eight convulsive children visited the Pediatric Department of Chungbuk National University...
Case Report
A Case of Tuberous Sclerosis with Hydrocephalus and Multiple Cardiac Tumors in Neonatal Period
Young Jun Song, Won Seop Kim, Beom Soo Park, Heon Seok Han
Clin Exp Pediatr. 2000;43(2):294-299.   Published online February 15, 2000
Several different tumors in different tissues(including the central nervous system, heart, kidney, liver, bone, and soft tissues) are found to be associated with tuberous sclerosis. In the brain, this tumor characteristically arises from the floor of the lateral ventricle and often occluded the foramen of Monro. Cardiac tumor is among the earliest signs of tuberous sclerosis and occurs in over...
Original Article
Seizure Types and EEG Findings of Juvenile Onset Idiopathic Generalized Epilepsy
Hyunmi Kim, Won Seop Kim, Jong Shin Kim, Kangho Cho, Ki Joong Kim, Yong Seung Hwang
Clin Exp Pediatr. 1997;40(7):991-998.   Published online July 15, 1997
Purpose : Juvenile myoclonic epilepsy, juvenile absence epilepsy, and epilepsy wth generalized tonic clonic seizure(GTCS) on awakening are the three syndromes of idiopathic generalized epilepsy of adolescent onset currently included in the classification of epilepsy syndromes of the International League Against Epilepsy(ILAE). Although they differ in their predominant seizure types, the syndromes share several seizure types. Also, there are no unique electrophysiologic or genetic markers....
Statistical studies on pediatric emergency room patients.
Won Seop Kim, Young Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1991;34(1):7-15.   Published online January 31, 1991
The studies were carried out to analyze the emergency patient visited to the emergency room of the National Medical Center under the 15 years old during the three-year period from Jan., 1985. to Dec., 1987 The results were obtained as below. 1) During the 3-year periods, the total number of emergency patients under the 15 years of age was 4,394. 2) Forty one percents of the total patient...
Clinical Analysis on Childhood Accidents.
Won Seop Kim, Youn Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1990;33(12):1631-1638.   Published online December 31, 1990
We carried out a stastical & clinical analysis on 2,593 cases of childhood accidents visiting emergancy room of National Medical Center during last 5 years, from Jan. 1, 1984 to Dec. 31, 1988. The results were as follows: 1) The total percent of accidents among EMR visitors showed 6% increase in 1988 compared to that of in 1984 2) The most common type of accidents was trauma...
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