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Respiratory distress syndrome(RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventiratory techniques.
After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested on RDS infants by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement... |
