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Original Article
Direct detection of hemophilia B F9 gene mutation using multiplex PCR and conformation sensitive gel electrophoresis
Ki Young Yoo, Hee Jin Kim, Kwang Chul Lee
Clin Exp Pediatr. 2010;53(3):397-407.   Published online March 15, 2010
Purpose : The F9 gene is known to be the causative gene for hemophilia B, but unfortunately the detection rate for restriction fragment length polymorphism-based linkage analysis is only 55.6%. Direct DNA sequencing can detect 98% of mutations, but this alternative procedure is very costly. Here, we conducted multiplex polymerase chain reactions (PCRs) and conformation sensitive gel electrophoresis (CSGE) to...
Molecular-epidemiologic study on outbreak of colonization by extended spectrum β-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit
Nu-Lee Jun, Mi-Na Kim, Jae-Sim Jeong, Yang-Soo Kim, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2006;49(2):150-156.   Published online February 15, 2006
Purpose : The aims of this study included assessment of molecular-epidemiologic features during an outbreak of colonization of extended spectrum β-lactamase producing Klebsiella pneumoniae(ESBL- KPN) and re-evaluation of their colonized status one year later. Methods : Rectal swab cultures for ESBL-KPN from all hospitalized infants and newly admitted infants were obtained during the outbreak of colonization from July to December,...
Comparison of Serum Proteome Maps of Children with Kawasaki Disease
Seoung Yon Baek, Young-Mock Lee, Kwang Hoon Lee, Dong Soo Kim
Clin Exp Pediatr. 2004;47(1):81-89.   Published online January 15, 2004
Purpose : Kawasaki disease is a systemic vasculitis observed in children under five years of age and the leading cause of pediatric acquired heart disease, but its pathophysiology is still not completely understood. With proteomics, the study of quality and quantity of proteins, having been developed dramatically, we tried to find a way to evaluate the etiology and pathogenesis of...
Molecular Epidemiologic Study of Streptococcus pyogenes Analyzed by T protein Serotyping and Pulsed Field Gel Electrophoresis(PFGE) in Normal Children
Jin Ah Son, Don Hee Ahn, Kyu Jam Hwang, Younghee Lee, Sung-Ho Cha
Clin Exp Pediatr. 2000;43(10):1330-1342.   Published online October 15, 2000
Purpose : In this study we tried to look at the spreading, duration of colonization, and acquisition of new streptococci which were obtained in one geographical area, as well as the bacteriologic and molecular epidemiology of normal school children carrying group A streptococci and their clonal relationship through the combined application of the serotype of T antigen and Pulsed Field...
An Electrophoretic Study of Serum and Cerebrospinal Fluid Proteins in Newborn Infants.
Hyeon Soo Park, Woo Gill Lee, Chong Moo Park
Clin Exp Pediatr. 1981;24(11):1021-1027.   Published online November 15, 1981
There are many diseases that have a characteristic protein electrophoretic patterns of serum and cerebrospinal fluid. The protein electrophoretic study of serum and cerebrospinal fluid has been used clinically for the diagnosis of such diseases. There are very few studies and references on this subject to available in Korea. Therefore authors studied the protein electrophoretic patterns of serum and cerebrospinal...
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