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Review Article
Infection
Recommendation for use of diphtheria and tetanus toxoids and acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate, and hepatitis B vaccine in infants
Hye-Kyung Cho, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Taek-Jin Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, Eun Young Cho, Jong Gyun Ahn, Eun Hwa Choi; The Committee on Infectious Diseases of the Korean Pediatric Society
Clin Exp Pediatr. 2021;64(12):602-607.   Published online June 8, 2021
∙ Diphtheria and tetanus toxoids and acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b-hepatitis B (DTaP-IPV-Hib-HepB) was licensed in Korea in April 2020.
∙ DTaP-IPV-Hib-HepB is indicated as a 3-dose primary series for infants aged 2, 4, and 6 months who received the standalone HepB vaccine at birth.
∙ Infants born to HepB surface antigen-positive mothers are currently recommended to be immunized with HepB immunoglobulin at birth and then monovalent HepB vaccine at 0, 1, and 6 months.
Recommendation for the use of newly introduced Tdap vaccine in Korea
Kyong Min Choi, Kyung Hyo Kim, Yae-Jean Kim, Jong-Hyun Kim, Su Eun Park, Hoan Jong Lee, Byung Wook Eun, Dae Sun Jo, Eun Hwa Choi, Young Jin Hong
Clin Exp Pediatr. 2011;54(4):141-145.   Published online April 30, 2011

Pertussis is an acute respiratory infection characterized by paroxysmal cough and inspiratory whoop for over 2 weeks. The incidence of pertussis has decreased markedly after the introduction of DTwP/DTaP vaccine, but the incidence of pertussis has increased steadily among young infant and among adolescents and adults in many countries. Td vaccine was used in this age group but the increase...

Update on pertussis and pertussis immunization
Jung Yun Hong
Clin Exp Pediatr. 2010;53(5):629-633.   Published online May 31, 2010

Pertussis is a highly contagious respiratory tract disease caused by Bordetella pertussis infection. The clinical manifestation of this infection can be severe enough to cause death. Although pertussis has been supposed to be a vaccine-preventable disease ever since the widespread vaccination of children against pertussis was started, since the 1990s, cases of pertussis and related fatalities are on the rise,...

Original Article
The immunogenicity and safety of three-component DTaP vaccine in Korean infants
Jin Han Kang, Jong Hyun Kim, Jung Hyun Lee, Soo Young Lee, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2007;50(4):355-362.   Published online April 15, 2007
Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine (Infanrix ) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy...
Epidemiologic and Clinical Features of Pertussis in Children(2000. 3-2001. 3)
Shin Yoo, Kyong Ouk Ahn, Eun Hye Park, Hyun Sang Cho, Chong Young Park, Hae Ran Lee
Clin Exp Pediatr. 2002;45(5):603-608.   Published online May 15, 2002
Purpose : Pertussis is a highly communicable infectious disease in children with high mortality, especially in young infants. The incidence of pertussis in South Korea has decreased to about 10 cases a year in late '90s. Doubting previously reported incidences of pertussis, we designed this study to establish exact epidemiology and a diagnostic basis of pertussis. Methods : From Mar. 2000...
Pertussis Antibodies in the Sera of Children after Acellular Pertussis Vaccination
Jeong Hwa Lee, Young Hee Ha, Ji Whan Han, Won Bae Lee, Kyong Su Lee
Clin Exp Pediatr. 1997;40(2):167-172.   Published online February 15, 1997
Purpose : The pertussis vaccines are divided into whole-cell vaccine and acellular vaccine. Purified component acellular pertussis vaccine, originally developed in Japan, has been used for primary immunization series in Korea since 1984. We performed this study to evaluate the prevalence of pertussis antibodies following vaccination with acellular pertussis vaccine. Methods : We randomized 80 children who were immunized according to vaccine schedules...
Diagnosis of Bordetella Pertussis Infections by Polymerase Chain Reaction
Mi Ran Kim, Hee Jung Kang, Hoan Jong Lee
Clin Exp Pediatr. 1996;39(9):1260-1270.   Published online September 15, 1996
Purpose : Pertussis, a respiratory tract infection caused by Bordetella pertussis, is an important cause of morbidity in children. But diagnosis of pertussis is often delayed because of late development of typical symptoms and difficulties in culture. There has been no bacteriologically confirmed case of B. pertussis infection in Korea. Lower respiratoy tract may be involved in pertussis. We performed the polymerase chain reaction(PCR)...
The effect of pertussis vaccine on streptozotocin induced diabetic rats.
Kyung Rae Moon, Kwang Rhun Koo, Sang Kee Park, Yeong Bong Park, Byoung Rai Lee, Keun Hong Kee
Clin Exp Pediatr. 1991;34(7):897-906.   Published online July 31, 1991
Streptozotocin produces diabetes in laboratory animals through the destuction of the pancreatic beta cells. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and petussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine (bPV; incubating the PV at 80 C for 30 mintues)...
The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(7):914-923.   Published online July 31, 1988
The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man. The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment...
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