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Case Report
Alveolar rhabdomyosarcoma with massive disseminated intravascular coagulopathy treated with systemic chemotherapy
Byung Gyu Yoon, Hee Jo Baek, Burm Seok Oh, Dong Kyun Han, Yoo Duk Choi, Hoon Kook
Clin Exp Pediatr. 2015;58(12):505-508.   Published online December 22, 2015

It is uncommon for pediatric patients with rhabdomyosarcoma to present with clinical and/or laboratory features of disseminated intravascular coagulation (DIC). We report a case of metastatic alveolar rhabdomyosarcoma with severe bleeding because of DIC in a 13-year-old boy. He experienced persistent oozing at the site of a previous operation, gross hematuria, and massive epistaxis. Two weeks after initiating combination chemotherapy...

Original Article
Antithrombin III in the Diagnosis and Treatment of Disseminated Intravascular Coagulation in Premature Infants
Su Jin Cho, Hye Ryung Choi, Young Mi Hong, Kyung Hee Kim, Keun Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(7):740-745.   Published online July 15, 2004
Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants. Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups...
Case Report
Two Cases of Disseminated Intravascular Coagulation Due to Status Epilepticus with High Fever
Song Heui Shin, Kyung-Rye Moon, Eun-Young Kim, Young-Il Rho
Clin Exp Pediatr. 2001;44(9):1062-1065.   Published online September 15, 2001
Status epilepticus has been occasionally reported as a cause of acute disseminated intravascular coagulation(DIC), but little is known regarding the pathogenesis of this uncommon association. The occurrence of DIC in status epilepticus may be related to widespread endothelial damage secondary to seizure-induced hyperpyrexia or status epilepticus due to high fever. We experienced two cases of status epilepticus accompanying fever in which laboratory data demonstrated...
Original Article
Hemorrhagic Shock and Encephalopathy Syndrome as a Cause of Sudden Death in Infants
Jong Won Lee, Chang Han Lee, Ki Sup Chung
Clin Exp Pediatr. 2000;43(6):814-819.   Published online June 15, 2000
Purpose : To evaluate the clinical characteristics, treatments and outcome of patients with hemorrhagic shock and encephalopathy(HSE) syndrome. Methods : We performed a clinical study on 14 patients who were diagnosed as hemorrhagic shock and having encephalopathy syndrome in the Department of Pediatrics, from 1984 to 1998. Age, sex, clinical symptoms and physical findings at admission, the most deranged laboratory findings,...
Diagnostic Utility of D-dimer Test in Disseminated Intravascular Coagulation with Sepsis
Jung Eun Kim, Young Mi Hong, Gyung Hee Kim
Clin Exp Pediatr. 1999;42(2):257-263.   Published online February 15, 1999
Purpose : Disseminated intravascular coagulation(DIC) is a confusing disorder from both a diagnostic and therapeutic standpoint. In order to investigate the effectiveness of D-dimer test in disseminated intravascular coagulation associated with sepsis, D-dimer level and other laboratory tests were performed. Methods : Fifty patients with disseminated intravascular coagulation associated with sepsis, who were admitted to the department of pediatrics, were evaluated by...
A Clinical Study of Antithrombin Ⅲ Therapy for Disseminated Intravascular Coagulation in Neonates
Ji Young Kim, Cheong Nyen Kim, Myoung Jae Chey, Cheol Young Cheong
Clin Exp Pediatr. 1998;41(5):593-598.   Published online May 15, 1998
Purpose : The purpose of this study is to evaluate the clinical effect of antithrombin Ⅲ concentrates in disseminated intravascular coagulation(DIC) of neonates. Methods : We reviewed the clinical records of 11 newborn patients who had been admitted and diagnosed as DIC at the neonatal intensive care unit of Sanggye Paik Hospital from November, 1995 to September, 1996. Results : There were...
Case Report
A Fatal Case of Systemic Juvenile Rheumatoid Arthritis with Disseminated Intravascular Coagulation
Eun Young Park, Sung Hee Oh
Clin Exp Pediatr. 1998;41(1):129-134.   Published online January 15, 1998
Disseminated intravascular coagulation(DIC) occurs rarely but can cause death in patients with juvenile rheumatoid arthritis(JRA), especially in the systemic type. The reports of DIC complicating JRA have increased recently. We experienced a 13 - year - old female patient with systemic JRA who died of DIC. The patient had been managed with aspirin, steroid, nonsteroidal anti-inflammatory drug for 7 years,...
A Case of Multicystic Encephalomalacia in a Liveborn Twin with a Stillborn Co-twin
Mi Ya Park, Kyung Hee Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1997;40(3):429-433.   Published online March 15, 1997
Multicystic encephalomalacia is the condition defined anatomically by the presence of multiple cavities in the great part of both cerebral hemispheres. The most common cause of the condition was regarded as the circulatory disturbance during the perinatal period. Also,neonatal asphyxia was the most important cause of the circulatory disturbance. But we experienced a case of multicystic encephalomalacia in a liveborn twin with a stillborn...
A Case of Symmetrical Peripheral Gangrene in Disseminated Intravascular Coagulation
Mi Jeong Kim, Seung Hee Park, Sun Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1994;37(11):1620-1623.   Published online November 15, 1994
The symmetrical peripheral gangrene syndrome consists of sudden onset of symmetrical gangrene of the fingers, toes and more raely, the nose, upper lip, ear lobes, or genitalia. There is no evidence of occulusion of large vessels or vasculitis. We experienced a case of symmetrical peripheral gangrene developed in fingers and toes with disseminated intravascular coagulation in 20 day-old permature infant with...
Original Article
The role of exchange transfusion as a therapy for neonatal DIC.
Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1991;34(1):31-40.   Published online January 31, 1991
A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet count, PT,...
Case Report
Disseminated Intravascular Coagulation in an Infant Born after Abruptio Placentae.
Soon Ung Kang, Jung Hwan Choi, E Boong Kwon, Chong Ku Yun, Kwang Wook Ko, Je G Chi, Chul Woo Kim
Clin Exp Pediatr. 1982;25(7):730-736.   Published online July 31, 1982
Premature separation of the placenta(abruptio placentae), as a serious obstetric complication, has been recognized to be associated with disseminated intravascular coagulation(DIC) in the newborn period. However, pathologic evidence for DIC generally has been lacking or rarely reported. Recently we have experienced one case of DIC in an infant born after abruptio placentae. The infant had suffered from cyanosis, dyspnea and...
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