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Original Article
Analysis of disease mechanism of subacute necrotizing lymphadenitis in children
Hyun Jung Kim, Jung Suk Yeom, Ji Suk Park, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Jae Min Cho, Jeong Hee Lee, Hee Shang Youn
Clin Exp Pediatr. 2008;51(11):1198-1204.   Published online November 15, 2008
Purpose : The cause of subacute necrotizing lymphadenitis, a rare disease in children, has not been completely clarified. This study was aimed to investigate the disease mechanism by examining clinical, radiologic, and immunohistochemical findings in children diagnosed with subacute necrotizing lymphadenitis after an excisional biopsy. Methods : We examined 19 lymph node tissue specimens from 17 children diagnosed with subacute...
Ultrastructure of nasal cilia in children with recurrent or persistent respiratory diseases
Su-A Shin, Seung Yang, Jae-Won Oh, Ha-Baik Lee, Cheol-Eon Park, Jung-Kyun Kwan
Clin Exp Pediatr. 2006;49(4):410-416.   Published online April 15, 2006
Purpose : Ciliary abnormalities of the respiratory system usually accompany recurrent or persistent respiratory diseases such as paranasal sinusitis, bronchiectasis, rhinitis, and/or otitis media, since they cause certain derangements in ciliary cleaning activities. This disease is usually inherited by autosomal recessive trait, but may also be found to be acquired or transient in rare cases after heavy exposure to pollutants,...
Diagnostic effectiveness of fine needle aspiration cytology on pediatric cervical lymphadenopathy
Jun Chul Byun, Byung Kyu Choe, Jin-Bok Hwang, Heung Sik Kim, Sang Sook Lee
Clin Exp Pediatr. 2006;49(2):162-166.   Published online February 15, 2006
Purpose : There are few reports in Korean literature on the diagnostic efficacy of fine needle aspiration cytology(FNAC) for pediatric cervical lymphadenopathy. This study examined the diagnostic value of FNAC on cervical lymphadenopathy in children. Methods : Data from 57 pediatric patients(aged 0.3 to 14 years) who underwent FNAC due to cervical lymphadenopathy between January 2001 and March 2005 was...
Clinical Evaluation of Tissue Biopsy for Children with Neck Mass; A Single Center Study
You Sook Youn, Hye Won Yoon, Sun Young Kim, Ji Young Sul, Chang Jun Song, Jin Man Kim, Kyung Duk Park
Clin Exp Pediatr. 2005;48(8):839-845.   Published online August 15, 2005
Purpose : Neck masses, in pediatric population, derive from a multitude of congenital, inflammatory, or neoplastic diseases. The majority of these masses represent benign conditions. However, thorough clinical evaluation is required to rule out malignant diseases. We evaluated the causes, clinical characteristics and outcomes of children with neck masses who underwent tissue biopsy. Methods : A total of 28 medical records...
The Utilities of Lung Biopsy in Pediatric Lung Disease
Jae Hee Lee, So Yeon Lee, Ja Hyung Kim, Bong Sung Kim, Soo-Jong Hong
Clin Exp Pediatr. 2003;46(12):1230-1234.   Published online December 15, 2003
Purpose : The aim of this study is to evaluate the value of lung biopsies for the management of children with lung disease. Methods : We retrospectively reviewed 19 lung biopsies done at Asan Medical Center, Seoul between 1993 and 2001. Data gathered included demographic information, underlying conditions, diagnosis before biopsy, final diagnosis, change in therapy, morbidity and mortality. Results : Nineteen...
Case Report
Hemophagocytic Syndrome with Kawasaki Disease and Peripheral Gangrene
Hwa Jun Yun, Ko Woon Jeon, Hwang Min Kim, Seok Won Park, Young Uh
Clin Exp Pediatr. 2002;45(5):664-668.   Published online May 15, 2002
A twenty six months-old boy developed hemophagocytic syndrome during the course of Kawasaki disease. Despite the appropriate treatment modalities for Kawasaki disease, he developed thrombocytopenia, hepatomegaly, high-grade fever, hypertriglyceridemia, peripheral gangrene, and evidence of hemophagocytosis in bone marrow biopsy. Although the course was stormy, he responded well to a combination therapy of corticosteroid and etoposide.
Original Article
Clinical Spectrum and Lung Pathology in Children with Interstitial Lung Disease
Ji-Hyun Chung, Seung-Ju Ha, Bong-Seong Kim, Soo-Jong Hong
Clin Exp Pediatr. 2002;45(1):79-87.   Published online January 15, 2002
Purpose : Interstitial lung disease(ILD) is a rare and poorly characterized disorder in children with poor prognosis. To understand the ILD in children, we reviewed our experience with 21 patients who were diagnosed interstitial lung disease during 9-year period at Asan Medical Center retrospectively. Methods : Severity-of-illness score was measured by the Denver protocol. We evaluated underlying diseases, clinical manifestations, high resolution computed tomography findings,...
Case Report
A Case of Hereditary Motor and Sensory Neuropathy Type III
Su Hyun Cho, Soo-Jin Kim, Young-Hoon Kim, Yun Tae Kim, Yoon-Kyung Lee, Dong-Un Kim, Seung-Hoon Han, Seung-Yun Chung, In-Goo Lee, Kyung-Tai Whang, Je Geun Chi
Clin Exp Pediatr. 2001;44(9):1057-1061.   Published online September 15, 2001
Hereditary motor and sensory neuropathy type III, which is also known as Dejerine-Sottas disease, is a severe demyelinating polyneuropathy which presents from birth or infancy, and is sometimes presented as a hypotonic or floppy infant. The disease is inherited autosomal recessively and includes clinical findings of generalized muscle weakness and atrophy, with the greatest severity in distal limb muscles, areflexia, and sensory loss. The...
Original Article
Comparison between Pathologically and Clinically Diagnosed Group of Acute Postinfectious Glomerulonephritis
Chul Hong Kim, Su Yung Kim
Clin Exp Pediatr. 1999;42(12):1696-1701.   Published online December 15, 1999
Purpose : Postinfectious acute glomerulonephritis usually needs no renal biopsy. But atypical clinical course and laboratory results indicate a need for renal biopsy. Therefore, to investigate clinicopathological characteristics of postinfectious acute glomerulonephritis, we compared clinical manifestations of biopsy group with those of non-biopsy group. Methods : We reviewed the records of clinical and pathological data of 20 cases diagnosed by...
Case Report
A Case of Congenital Intestinal Lymphangiectasia
Pan Joo Lim, Jae Ock Park, Dong Hwan Lee, Sang Mann Shin, Dong Won Ki
Clin Exp Pediatr. 1998;41(9):1293-1298.   Published online September 15, 1998
Intestinal lymphangiectasia is a primary or secondary disorder of lymphatics which is associated with protein-losing enteropathy, hypoalbuminemia, edema, abdominal distension and growth failure. The patients with this disease lose albumin, immunoglobulins, and lymphocytes through the bowel. We have experienced one case of intestinal lymphangiectasia in 8 month-old boy, whose chief complaint was abdominal distension and watery diarrhea. He had hypoalbuminemia(1.7gm/dl)....
Original Article
The Diagnostic Value of Liver Biopsy in Children with Fever of Unknown Origin and Hepatosplenomegaly
Sue Mee Park, Yeon Ho Choi, Jong Jae Kim, Hoan Jong Lee, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(11):1544-1555.   Published online November 15, 1996
Purpose : Although many strides have been made in the radiological and laboratory diagnosis, the liver biopsy is still considered an important tool for the diagnosis of liver disease. We report our experience that histologic investigation of the liver was essential searching for the etiologic diagnosis in eight children with fever of unknowm origin and hepatosplenomegaly, who's diagnosis were not documented by other diagnostic...
Case Report
Pseudoaneurysm after Renal Biopsy; Angigraphic Diagnosis and Treatment by Superselective Embolization
Sin Weon Yun, Keun Seop Jung, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Byeong Heun You, Hyung Jin Shim, Young Ku Kim
Clin Exp Pediatr. 1995;38(3):417-421.   Published online March 15, 1995
The use of superselective embolization was assessed as a treatment for bleeding from arteriovenous fistulas and pseudoaneurysm after renal biopsy procedure. But unless it is sufficiently selective, the procedure results in loss of significant amount of renal parenchyme. We experienced one case of renal arterial pseudoaneurysm, which happened at 5days after percutaneous renal biopsy. Diagnosis of pseudoaneurysm was made by...
Original Article
Ultrasound-Guided Percutaneous Renal Biopsy in 420 Children
Byoung-Soo Cho, Wan-Young Shin, Young-Tae Ko, Moon-Ho Yang
Clin Exp Pediatr. 1995;38(3):347-352.   Published online March 15, 1995
Purpose : Ulrasound-quided percutaneous renal biopsy in useful in diagnosis of renal diseases and assessment of progression. We performaed 420 cases of percutaneous renal biopsy in children since 1980. We analysis the method, results and complications. Methods : We used modified Vim-Silverman needle or Biopty?gun (pat 4699154, BARD) with Toshiba, 4 MHz GCE-406, aspiration transducer. Sedation was done by demerol(1mg/kg IM)...
Diagnosis of Thoracic Lesions in Children by Fine Needle Aspiration Biopsy
Dong Nam Kim, Nam Su Kim, Hahng Lee, Jong Sung Kim, Suk Chul Jeon
Clin Exp Pediatr. 1994;37(11):1559-1564.   Published online November 15, 1994
To elucidate the clinical availability of FNAB, we reviewed retrospectively medical records of 30 patients who had infiltrative pulmonary lesion or pulmonary nodule of mediastinal mass, and got percutaneous fine needle aspiration biopsy using Wescott needle, 20~22 gauge, at the department of Pediatrics, Hanyang university hospital from July, 1986 to June, 1993. The obtained results were as follow: 1) There were 30...
Acute Tubular Necrosis Associated with typhoid Fever
Pill-Jin Shin, Ho-Sung Lee, Byoung-Soo Cho, Chang-Il Ahn, Mun-Ho Yang
Clin Exp Pediatr. 1994;37(2):250-256.   Published online February 15, 1994
Acute tubular necrosis has been rarely reported as a complication of typhoid fever in the literature. We experienced four cases of acute tubular necrosis associated with typhoid fever in children. Patients showed significant titer of widal reaction associated with acute renal failure and one of them rised in 2 months after onset of clinical symptoms. Renal biopsy findings were compatible with acute...
Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)
Hyun Ho Shin, Jae Yoon Kim, Chong Woo Bae, Sung Ho Cho, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1992;35(11):1509-1513.   Published online November 15, 1992
Idiopathic hypercalciuria is defined as excessive urinary excretion of calcium in normocalcemia without any primary cause. We performed the sono-guided percutaneous renal biopsy for patients of recurrent hematuria, persistent microscopic hematuria, proteinuria and RBC cast to evaluate underlying nephropathy. We could obtained the following results 1) The age at the renal biopsy ranged from 3 years to 14 years. Sex ratio is 1.9:1...
Case Report
Acute Tubular Necrosis Associated with Typhoid Fever
Sung-Yoon Cho, Kyu-Young Lee, Sung-Ho Cha, Byoung-Soo Cho, Chang-Il Ahn, So-Yeon Yu, Mun-Ho Yang, Soon-Don Hong
Clin Exp Pediatr. 1992;35(6):867-872.   Published online June 15, 1992
Acute tubular necrosis has been rarely reported in typhoid fever. We experienced a case of acute tubular necrosis due to typhoid fever in a 5 years old male patient. The patient showed significant titer of widal reaction associated with acute renal failure. Renal boipsy finding was compatible with acute tubular necrosis and immune complex was not deposited. Clinical and urinary...
Original Article
A Clinicopathological Study on Renal Biopsies in Children
Hun Choi, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(6):744-752.   Published online June 15, 1992
A clinical and histopathologic study was made oin 50 cases of renal biopies in children who admitted to chon buk national university hospital from December 1987 to July 1990. The result were as follows : 1) Among 50 cases, 35 cases were male and 15 cases female. The sex ratio of male to female was 2.3 : 1. The age distribution was...
Re-evaluation of the indication for renal biopsy in childhood nephrotic syndrome.
Eun Kyoung Sohn, Byung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1991;34(6):805-811.   Published online June 30, 1991
Renal biopsy is indicated in nephrotic syndrome when histopathologic types other than minimal change pattern or the secondary nephrotic syndrome are suspected. But renal biopsy in children has some limitation because of the technical problem. In order to assess the clinicopathologic correlation and to re-evaluate the biopsy indication, the clinical manifestations and histopathologic types were analyzed statisically on the 86 cases of childhood nephrotic syndrome...
Complication of Percutaneous Renal Biopsy in Children.
Seo Jeong Kim, Jae Seung Lee, Pyung Kil Kim
Clin Exp Pediatr. 1987;30(9):1001-1013.   Published online September 30, 1987
Percutaneous renal biopsy is presently used more widely and selectively with fewer complications and a higher success rate than in the past. The improved methods of renal biopsy tissue handling and staining and the correlation of light microscopy results with those of electron and immunofluorescent microscopy have led to a quantum increase in our knowledge of renal diseases and have given great impetus to...
A Clinicopathological Study on Re nal Biopsies in Children.
Soon Wha Kim, Keun Chan Sohn
Clin Exp Pediatr. 1986;29(8):868-879.   Published online August 31, 1986
A clinical and histopathologic study was made on 80 cases of renal biopsies in children who were admitted to National Medical Center from January 1976 to June 1985. The results are as follows: 1) Among 80 cases, 60 cases were male and 20 cases female. The sex ratio of male to female was 3 : 1. The age distribution was from...
A Clinicopathological Study on the Biopsy-proven Henoch-Schonlein Purpura Nephritis in Children.
Jong Yoon Kim, Yong Choi, Kwang Wook Ko, Young il Kim
Clin Exp Pediatr. 1986;29(3):265-276.   Published online March 31, 1986
40 patients with Henoch-Schonlein nephritis in whom a per cutaneous renal biopsy was performed at department of pediatrics, Seoul National University Hospital during the periods Jan. 1978-Jan. 1985 inclusive were analyzed in view of clinicopathological correlation. The results were as follows: 1) Of the 40 patients reviewed, 24 cases were male and 16 female. The mean age of onset was 9 years...
Study on Clinical Findings and Histopathologic Types in Biopsy Proven Glomerular Diseases in Korean Children.
Jae Seung Lee, Young Cherl Lee, Pyung Kil Kim, Hyeon Joo Jeong, In Joon Choi
Clin Exp Pediatr. 1986;29(2):143-151.   Published online February 28, 1986
A clinical and pathologic study was made on 360 cases of renal biopsies in children who were admitted to Severance Hospital, Yonsei University College of Medicine, from Jan. 1979 to Dec. 1984. 1) Among 360 cases, 250 cases were male and 110 cases were female. The sex ratio of male and female was 2.3 : 1. The distribution was from 1 6/12...
Clinical Analysis of the Neck Mass in Childhood.
Jong Sic Joo, Chan Yung Kim
Clin Exp Pediatr. 1985;28(10):1007-1016.   Published online October 31, 1985
For evaluation of clinical characteristics, 228 cases of neck mass in childhood were reviewed, which were surgically removed and pathologically diagnosed during the period from January 1973 to August 1984 at the pediatric department of Pusan National University Hospital. The results are summarized as follows: 1)Histologically the most common lesion was nonspecific lymphadenitis (31.6%) and next was tuberculous lymphadenitis(17.1%). The congenital...
Case Report
Acute Werdnig-Hoffmann Diseases in Siblings.
Y D Lee, Y W Lee, J H Lee, Y H Chung
Clin Exp Pediatr. 1985;28(8):823-828.   Published online August 31, 1985
Acute Werdnig-Hoffmann diseases being the most common cause of floppy infant, in two male siblings were presented. The patients appeared characteristic clinical findings suggestive of spinal atrophy at 4 weeks and 2 months and all died about 8 months old. Previous expired another elder-brother was also related to this disease. Diagnosis was estabilished by clinical & pathologic findings. This is the...
Original Article
A Clinicopathological Study on Renal Biopsies in Children.
Chung Hye Chu, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1985;28(7):705-713.   Published online July 31, 1985
A clinical and histopathological study was made on 53 cases of ultrasonoguided renal biopsies in children who were admitted to pediatric ward of Kyung Hee University Hospital, from February 1, 1979 to March 31, 1984. The result were as follows: 1)The final diagnosis was confirmed by ultrasonoguided renal biopsy in this 53 cases and there was no severe complication (perirenal hematoma, renal...
Case Report
A Case of Primary Hepatocellular Carcinoma in Infancy .
H Y Kim, S W Ahn, Y S Kim, C Y Kim, J W Yang
Clin Exp Pediatr. 1984;27(12):1227-1233.   Published online December 31, 1984
Primary hepatoma is relatively rare tumor in infants an children. The incidence among 1000 hospitalized children in pediatric clinic is about 0.05-0.06. The author experienced, a case of primary hepatoma occurred, in 3-months-old male who was admitted to the Pusan II Sin Women’s Hospital with symptom of progressively growing palpable mass on the right upper quadrant. Under the procedure of explorative laparatomy, the hard mass...
A Case of Lung Metastasis of Testicular Yolk Sac Tumor.
Ho Ju Yoon, Hyun Kyung Cho, Jung Sik Chun, Chang Kyu Oh, Mahn Kyoo Yang
Clin Exp Pediatr. 1982;25(12):1275-1279.   Published online December 31, 1982
First admission; A 4 year old male patient was admitted with progressive swelling and tenderness of left scrotum since birth. Left simple orchiectomy was performed. The histolo- gic finding was testicular yolk sac tumor. Second admission; 2 years later. The patient was readmitted with migrating pain and limitation of motion of lower extremities. Lung metastasis (LLL extending to lingular lobe) was appeared. During chemotherapy, he...
Original Article
Clinicostatistical Study of Tumors in Children confirmed by Biopsy.
Si Man Lee, Sang Ki Min, Sung Hwan Kim, Kyung Hae Park, Sang Ghern Chung, Chan Yung Kim
Clin Exp Pediatr. 1982;25(10):1007-1014.   Published online October 31, 1982
biopsy or bone marrow biopsy at Busan National University Hospital from 1970 to 1980. The following results were obtained; 1. The requested cases for biopsy were increased annually, but the numbers and discovery- rate of malignant and benign tumors were not increased significantly. 2. The numbers of malignant tumor after 6years of age were higher than under 6years of age, but discovery rate of Clinicostatistical syudy was...
Case Report
A case of lamellar ichthyosis.
Dong Whan Cha, Kwan Sup Chung, Kwang Ho Kim, Duk Hyun Kim
Clin Exp Pediatr. 1982;25(9):967-971.   Published online September 30, 1982
One case of rare form of lamellar ichthyosis was reported. On admission, the entire skin surface of this infant was covered with parchment-like membrane especially below both ears and extensor surface of upper arms. Masked face, eversion of both lips and fixed semiflexion attitude of the upper limbs were also noted. Diagnosis of lamellar ichthyosis was made by clinical features, histcpathological and laboratory studies. A brief review...
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