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Original Article

The Effects of Adriamycin on Ionic Currents in Single Cardiac Myocytes of the Rabbit

Sejung Sohn

Clin Exp Pediatr. 1995;38(8):1093-1106. Published online August 15, 1995

Purpose : The study objective was to elucidate the possible pathophysiologic mechanism of Ca overload by adriamycin (ADR) which is associated with ADR- induced cardiotoxicity. Methods : The effects of ADR on ionic currents were studied using the whole cell voltage clamp technique in single cardiac myocytes of the rabbit. Results : The magnitude of the inward tail current, recorded at -70mV...

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