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Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review

Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2023.00514    [Accepted]
Published online December 6, 2023.
Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review
Nabila Hanem Arshad1,2  , Hasyma Abu Hassan1  , Nur Farhayu Omar1  , Zurina Zainudin3 
1Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Persiaran Universiti 1, 43400 Serdang, Selangor, Malaysia
2Department of Radiology, Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia, Persiaran UPM-MARDI, 43400 Serdang, Selangor, Malaysia
3Department of Paediatrics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Persiaran Universiti 1, 43400 Serdang, Selangor, Malaysia
Correspondence: 
Nabila Hanem Arshad, Email: hanem@upm.edu.my
Received: 29 March 2023   • Revised: 11 August 2023   • Accepted: 12 August 2023
Abstract
This review aimed to assess the usefulness of various magnetic resonance imaging (MRI) techniques for the quantification of neonatal white matter myelination. The Scopus, PubMed, and Web of Science databases were searched to identify studies following the PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement using quantitative MRI techniques to examine samples collected from neonates to quantify myelin. Twelve studies were ultimately included. The results demonstrated that in validation studies, relaxometry is the most frequently explored approach (83.33%), followed by magnetization transfer imaging (8.33%) and a new automatic segmentation technique (8.33%). Synthetic MRI is recommended for quantifying myelin in neonates because of several advantages that outweigh a few negligible limitations.
Key Words: Brain, Magnetic resonance imaging, Myelin, Neonate, Quantitative


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