Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2022.00234    [Accepted]
Published online May 19, 2022.
Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study
Mahendra Kumar Pant1, Abul Hasan Ahmad2, Manisha Naithani3, Jayanti Pant4 
1Department of Anatomy, Government Doon Medical College, Dehradun-248001, Uttarakhand, India
2College of Veterinary Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar- 263145, Uttarakhand, India
3Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh- 249203, Uttarakhand, India
4Department of Physiology, AIIMS, Rishikesh, Uttarakhand, India
Correspondence: 
Jayanti Pant, Email: pant.jayanti@gmail.com
Received: 9 February 2022   • Revised: 7 April 2022   • Accepted: 28 April 2022
Abstract
Background
Plastic bottles are widely used by people to feed their infants when breastfeeding is not possible. Bisphenol A (BPA), an endocrine disruptor is widely used in the manufacturing of plastic wares and is leached out from these plastic wares on exposure to high temperature, changed pH or cleaning the plastic wares by harsh detergents.
Purpose
Feeding through plastic bottles over prolong duration is expected to expose the infants to leached BPA. Hence the present study was taken up to compare the effects of breastfeeding and plastic bottle feeding on biochemical parameters in infants and also detect for the presence of free BPA or its metabolite in the infants.
Methods
Biochemical tests like lipid profile, liver function tests, creatine-kinase – MB (CK-MB), serum urea, serum electrolytes were performed on blood samples obtained from infants who were breastfed and plastic-bottle fed. Further, plasma and urine samples of the infants were subjected to Liquid chromatography–mass spectrometry analysis for detecting free BPA and BPA glucuronide.
Results
Biochemical changes in form of raised triglycerides, cholesterol, low density lipoproteins, very low-density lipoproteins and increase in CK-MB, serum urea was observed in plastic-bottle fed infants. BPA glucuronide was also detected in the urine of these infants. Free BPA was not detected in plasma or urine samples of the infants except in one plasma sample from bottle-fed group.
Conclusion
Plastic bottle feeding may lead to toxic changes in the functioning of organs which manifest as altered biochemical parameters.
Key Words: infants, breast feeding, Bisphenol A, leached, LCMS


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