| Studies on Serum Proteins by Electrophoresis in the Renal Disease |
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Kwang Chung Kim, Young Won Kim, Joo Ryong Kim |
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Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea |
| 腎疾患에 있어서의 電氣泳動法에 依한 血淸蛋白에 關한 硏究 |
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金光井, 金英嫄, 金周龍 |
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漢陽大學校 醫科大學 小兒科學敎室 |
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| Abstract |
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We studied serum protein fractions by Cellulose-Acetate Membrane Immunoelectrophoresis, which were included 80 cases of acute glomerulonephritis and 7 cases of nephrotic syndrome, and compared with 20 cases of normal healthy children as control group. The results were as follows; 1.In 80 cases of acute
lomerulonephritis, generally the distribution of serum protein fractions were summerized as follows; Albumin, arand /3-globulin were decreased ' slightly and. arglobulin increased slightly, but ^-globulin was increased markedly than control group. Serum protein fractions were compared by severity of disease (Group I to IV): Group I showing normal or only slightly elevated BUN and blood pressure; Group II showing markedly
increased BUN and decreased urinary output but normal or only slightly elevated blood pressure; Group IH showing markedly increased blood pressure but normal or slightly :elevated BUN; Group IV showing markedly increased BUN and blood pressure and diminished urinary output, and may complicate with hypertensive encephalopathy, cardiac failure and renal failure. In Group I to III, no significant changes in fraction levels except 7-globulin which was markedly increased in Group I and III. But Group IV revealed 47. Z% of Albumin for 58.2%
of controlgroup, 8.4% of /3-globulin for 11.7% of control group, and 29. 2% of 7-globulin for 5.5% of control group. 2.In 7 cases of nephrotic syndrome, total protein, albumin, i-and y-globulin were decreased, and a2 and /9-globulin were increased. Significant changes in serum total protein showed 5. 0gm% for 7.26. gm % of control group, and a2-globulin showed 28.1% for 9.56% of control group, which were more marked changes in nephrotic syndrome. 3. In control group, our studies for serum protein fractions were revealed almost sameas
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