Journal of the Korean Pediatric Society 1966;9(5):293-302.
Published online September 30, 1966.
The Clinical Studies of Congenital Syphilis
Jang Jae Jo, Young Shin Kwark, Myeong Jong Kim, In Kyu Kim, Kyong Ja Yun
Deparment of Pediatrics School of Medicine, Pusan University
先天梅毒에 對한 臨皮的觀察(12例)
趙璋濟, 金鳴鍾, 郭英信, 尹敬子, 金寅圭
釜山大學校醫科大學 小兒科擧敎室
The authors observed 12 cases of congenital syphilis in infants seen and treated at Pusan Childrens Charity Hospital and The Save the Children Fund Clinic Pusan Korea during the period from Dec. 1964 to Apr. 1966. The results are as follows; 1)The highest incidence was in babies from 2 weeks of age to 3 months. First symptoms appeared between 2 and 4 weeks of age in 10 of the 12 infants. The ratio of female to male was 3 : 1. 2)Snuffles, skin eruptions, hepatosplenomegaly, mucous diarrhea, conjunctivitis and pseudoparalysis were the most common early presenting symptoms and signs. 3)Anemia, malnutrition (92%), bony changes (90%), hepatomegaly (75%) and snuffles (67%) were the most common presenting symptoms and nigns. 4) 10 of the eleven infants who had X-rays taken showed syphilitic changes in the bones. Periosteal thickening was found in 10 cases, chondroepiphysitis, osteochondritis and metaphysitis were seen in 4 cases. Three of these 4 cases had pseudoparalysis. 5)All infants and their mothers had positive cardiolipin tests, the cardiolipin reactions of the infants remained positive during 3 months of treatment, although clinical symptoms and Signs disappeared. 6)The response to treatment with procain penicillin resulted in improvement in the clinical symp- toms, but syphilitic bone changes and anemia were not remarkably improved. Bony changes became aggravated within one month of treatment and began to improve after 2 months of treatment and disappeared within 8 months from the begining of treatment in the most cases. 7)A Herxheimer reaction occured briefly during treatment with penicillin in only one case, it was not necessary to stop or modify the treatment. 8)8 out of the 12 patients had complications during or after treatment, 6 out of the 8 infants had pneumonia 4 cases expired, 3 of those died of pneumonia and the other one died of amebiasis.

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