Journal of the Korean Pediatric Society 1973;16(5):388-391.
Published online May 31, 1973.
Treatment of Vasopressin-Sensitive Diabetes Insipidus with Chlorpropamide
Choon Ji Suh, Bang Sup Lee, Chung II Kim, Churl Young Chung
Department of Pediatrics, Catholic Medical College Seoul, Korea
Chlorpropamide 에 의한 Vasopressin 에 반응하는 요붕증의 치험례
서춘지, 이방섭, 김정일, 정철영
가톨릭 의과대 학 소아과학교실
Oral chlorpropamide therapy was assessed in 9 years-old male who entered with the complaints of polyuria, polydipsia and nocturia for 9 months. A significant reduction in urine vloume and increase in urine specific gravity occurred by its use. Mean 24 hour urine output during control periods was 5,460 ml (range, 5,300~5,700 ml) and mean urine specific gravity was 1; 005 (range, 1, 003~1, 007) on the time of admission. On chlorpropamide therapy, mean output fell to 1, 810 ml (range, 1, 200~2, 500 ml) and mean specific gravity rose to 1, 013 (range 1, 011~1,014). For many children with vase pressin -sensitive diabetes insipidus, chlorpropamide seems to be an effe- ctive form of therapy. The most recent experimental evidence suggests that the antidiuretic action of the drug may be due to an effect on the renal tubule, where by the latter’s sensitivity to small amounts of vasopressin may be enhanced.

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