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Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/kjp.2018.07150    [Accepted]
Published online September 27, 2019.
Thyroid disturbances in children treated with combined Pegylated Interferon alpha and Ribavirin for chronic hepatitis C.
Yasser K. Rashed1  , Fatma A. Khalaf2, Sobhy E. Kotb3
1Department of Pediatric Hepatology, National Liver Institute, Menoufia University, Egypt
2Department of Clinical Biochemistry, National Liver Institute, Menoufia University, Egypt
3Department of Pediatric Medicine, Ministry of health hospital, Egypt
Correspondence: 
Yasser K. Rashed, Tel: +2-048-222-2740, Fax: +2-048-223-4586, Email: yasserrashed79@yahoo.com
Received: 7 October 2018   • Revised: 18 August 2019   • Accepted: 21 August 2019
Abstract
Background
Immunomodulatory properties of interferon (INF) have been documented. It may induce autoimmune diseases such as Autoimmune Thyroiditis with hypo - or hyperthyroidism. In addition it may impair thyroid hormone synthesis through affecting iodide organification in thyroid gland.
Purpose
of this study was to describe thyroid function tests disturbances in children with chronic hepatitis C (CHC) receiving Pegylated interferon alpha (PEG FN-α) plus Ribavirin.
Methods
Fifty children with chronic Hepatitis C Virus (HCV) infection who received combined Pegylated interferon alpha with Ribavirin were selected. Other fifty apparently healthy children of matched age and sex (considered as control group) were selected. All children (100) were subject to liver function tests, virological studies and follow up of thyroid function test during and after the treatment course.
Results
Our study showed that 28% of children received combined PEG IFN-α plus Ribavirin showed subclinical hypothyroidism. After 24 weeks treatment with combined therapy of IFN plus Ribavirin, the mean level of TSH was 3.23±88 mU/ml, while TSH was 1.16 ± 0.77 mU/ml before starting treatment. On the other hand mean TSH was 1.09±0.92 mU/ml in normal control group.
Conclusion
This study revealed an association between subclinical thyroid dysfunction and treatment with IFN-alpha and Ribavirin in children. Further studies on larger number of patients and longer follow up duration are recommended for further confirmation.
Key Words: Interferon, Thyroid, Ribavirin, Hypothyroidism.




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